A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin

MicroRNA-29 (miR-29) negatively regulates fibrosis and is downregulated in multiple fibrotic organs and tissues, including in the skin. miR-29 mimics prevent pulmonary fibrosis in mouse models but have not previously been tested in the skin. This study aimed to identify pharmacodynamic biomarkers of...

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Veröffentlicht in:	Journal of investigative dermatology Jg. 139; H. 5; S. 1073
Hauptverfasser:	Gallant-Behm, Corrie L, Piper, Joseph, Lynch, Joshua M, Seto, Anita G, Hong, Seok Jong, Mustoe, Thomas A, Maari, Catherine, Pestano, Linda A, Dalby, Christina M, Jackson, Aimee L, Rubin, Paul, Marshall, William S
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.05.2019
Schlagworte:	Animals Biopsy, Needle Disease Models, Animal Extracellular Matrix - drug effects Extracellular Matrix - metabolism Fibrosis - genetics Fibrosis - pathology Gene Expression Regulation Humans Immunohistochemistry Mice MicroRNAs - genetics MicroRNAs - pharmacology Prospective Studies Skin Diseases - drug therapy Skin Diseases - genetics Skin Diseases - pathology Treatment Outcome
ISSN:	1523-1747, 1523-1747
Online-Zugang:	Weitere Angaben
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