A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin

MicroRNA-29 (miR-29) negatively regulates fibrosis and is downregulated in multiple fibrotic organs and tissues, including in the skin. miR-29 mimics prevent pulmonary fibrosis in mouse models but have not previously been tested in the skin. This study aimed to identify pharmacodynamic biomarkers of...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of investigative dermatology Vol. 139; no. 5; p. 1073
Main Authors:	Gallant-Behm, Corrie L, Piper, Joseph, Lynch, Joshua M, Seto, Anita G, Hong, Seok Jong, Mustoe, Thomas A, Maari, Catherine, Pestano, Linda A, Dalby, Christina M, Jackson, Aimee L, Rubin, Paul, Marshall, William S
Format:	Journal Article
Language:	English
Published:	United States 01.05.2019
Subjects:	Animals Biopsy, Needle Disease Models, Animal Extracellular Matrix - drug effects Extracellular Matrix - metabolism Fibrosis - genetics Fibrosis - pathology Gene Expression Regulation Humans Immunohistochemistry Mice MicroRNAs - genetics MicroRNAs - pharmacology Prospective Studies Skin Diseases - drug therapy Skin Diseases - genetics Skin Diseases - pathology Treatment Outcome
ISSN:	1523-1747, 1523-1747
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!