Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report

Serotonin syndrome (SS) is a potentially life-threatening condition that can be caused by use of proserotonergic drugs. Several studies have reported that combined administration of various medications may induce SS. We report a case of SS in a patient who was being treated with dopaminergic and nor...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Clinical neuropharmacology Ročník 40; číslo 4; s. 180
Hlavní autoři:	Jeon, Dae Geun, Kim, Yong Wook, Kim, Na Young, Park, Jung Hyun
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2017
Témata:	Adrenergic Uptake Inhibitors - administration & dosage Adrenergic Uptake Inhibitors - adverse effects Akinetic Mutism - diagnostic imaging Akinetic Mutism - drug therapy Akinetic Mutism - etiology Atomoxetine Hydrochloride - administration & dosage Atomoxetine Hydrochloride - adverse effects Benserazide - administration & dosage Benserazide - adverse effects Cerebral Hemorrhage - complications Cerebral Hemorrhage - diagnostic imaging Cerebral Hemorrhage - drug therapy Dopamine Agents - administration & dosage Dopamine Agents - adverse effects Dopamine Uptake Inhibitors - administration & dosage Dopamine Uptake Inhibitors - adverse effects Drug Combinations Drug Therapy, Combination Humans Levodopa - administration & dosage Levodopa - adverse effects Male Methylphenidate - administration & dosage Methylphenidate - adverse effects Middle Aged Serotonin Syndrome - chemically induced Serotonin Syndrome - complications Serotonin Syndrome - diagnostic imaging
ISSN:	1537-162X, 1537-162X
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Serotonin syndrome (SS) is a potentially life-threatening condition that can be caused by use of proserotonergic drugs. Several studies have reported that combined administration of various medications may induce SS. We report a case of SS in a patient who was being treated with dopaminergic and noradrenergic drugs. A 55-year-old man with a right frontal intracerebral hemorrhage extending to the left cerebral hemisphere presented with clinical features of akinetic mutism. Three months after onset, dopaminergic (methylphenidate, levodopa/benserazide) and noradrenergic (atomoxetine) drugs were administered to enhance his cognitive function. His cognitive function gradually improved during 8 weeks of dose escalation. One day after the dose of atomoxetine was increased from 40 mg/d to 60 mg/d, the patient developed inducible clonus, rigidity, diarrhea, tachycardia, and hyperthermia, in keeping with a diagnosis of SS. The symptoms and signs suggestive of SS resolved on the day following cessation of all dopaminergic and noradrenergic drugs. This case demonstrates that medications generally known as dopaminergic or noradrenergic agents could have serotonergic effects via a mechanism that is yet to be fully elucidated. The clinical manifestations of SS can be diverse, ranging from mild to severe and potentially fatal symptoms. When administering a combination of catecholaminergic agents, clinicians should carefully monitor the patient's neurologic status for unexpected adverse reactions.
Bibliografie:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1537-162X 1537-162X
DOI:	10.1097/WNF.0000000000000220