Inflammaging and the Skin

As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift...

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Bibliographic Details
Published in:Journal of investigative dermatology Vol. 141; no. 4S; p. 1087
Main Authors: Pilkington, Suzanne M, Bulfone-Paus, Silvia, Griffiths, Christopher E M, Watson, Rachel E B
Format: Journal Article
Language:English
Published: United States 01.04.2021
Subjects:
Cellular Senescence - immunology
Cytokines - metabolism
Fibroblasts - immunology
Fibroblasts - metabolism
Fibroblasts - pathology
Healthy Aging - immunology
Humans
Immunosenescence
Inflammation - immunology
Keratinocytes - immunology
Keratinocytes - metabolism
Keratinocytes - pathology
Langerhans Cells - immunology
Langerhans Cells - metabolism
Langerhans Cells - pathology
Skin - cytology
Skin - immunology
Skin - metabolism
Skin - pathology
Skin Aging - immunology
Skin Aging - pathology
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
T-Lymphocytes - pathology
ISSN:1523-1747, 1523-1747
Online Access:Get more information
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Summary:As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed to drive many age-associated conditions, including dementia, arthritis, and type 2 diabetes. As with other organs, the skin undergoes functional decline during aging, becoming more fragile and susceptible to infection; however, the contribution of inflammaging is not well-understood. This review article describes the evidence for inflammaging in the skin, its relationship with senescence, and how this relates to declining skin structure and function.
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ISSN:1523-1747
1523-1747
DOI:10.1016/j.jid.2020.11.006