CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses

T lymphocytes play an important role in atherosclerosis development, but the role of the CD8+ T-cell remains debated, especially in the clinically relevant advanced stages of atherosclerosis development. Here, we set out to determine the role of CD8+ T-cells in advanced atherosclerosis. Human endart...

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Veröffentlicht in:	Cardiovascular research Jg. 115; H. 4; S. 729
Hauptverfasser:	van Duijn, Janine, Kritikou, Eva, Benne, Naomi, van der Heijden, Thomas, van Puijvelde, Gijs H, Kröner, Mara J, Schaftenaar, Frank H, Foks, Amanda C, Wezel, Anouk, Smeets, Harm, Yagita, Hideo, Bot, Ilze, Jiskoot, Wim, Kuiper, Johan, Slütter, Bram
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 15.03.2019
Schlagworte:	Animals Arteries - immunology Arteries - metabolism Arteries - pathology Atherosclerosis - genetics Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - pathology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Communication Cells, Cultured Cellular Microenvironment Collagen - metabolism Disease Models, Animal Humans Macrophages - immunology Macrophages - metabolism Male Mice, Knockout, ApoE Necrosis Plaque, Atherosclerotic Receptors, LDL - deficiency Receptors, LDL - genetics Signal Transduction Th1 Cells - immunology Th1 Cells - metabolism CD8+ T-cells Inflammation Atherosclerosis
ISSN:	1755-3245, 1755-3245
Online-Zugang:	Weitere Angaben
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