Using matrix-induced ion suppression combined with LC-MS/MS for quantification of trimethylamine-N-oxide, choline, carnitine and acetylcarnitine in dried blood spot samples

Recently, there has been significant interest in the influences of the human gut microbiota on many diseases, such as cardiovascular disease (CVD) and metabolic disorders. Trimethylamine N-oxide (TMAO) is one of the most frequently discussed gut-derived metabolites. Dried blood spot (DBS) sampling h...

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Bibliographic Details
Published in:	Analytica chimica acta Vol. 1149; p. 338214
Main Authors:	Lu, Wan-Hui, Chiu, Huai-Hsuan, Kuo, Han-Chun, Chen, Guan-Yuan, Chepyala, Divyabharathi, Kuo, Ching-Hua
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 08.03.2021
Subjects:	Acetylcarnitine Blood volume correction Carnitine Choline Chromatography, Liquid Dried blood spot (DBS) Dried Blood Spot Testing Humans Mass spectrometry Matrix induced ion suppression (MIIS) Methylamines Oxides Reproducibility of Results Tandem Mass Spectrometry Trimethylamine N-Oxide (TMAO) Matrix induced ion suppression (MIIS) Blood volume correction Dried blood spot (DBS) Trimethylamine N-Oxide (TMAO) Mass spectrometry
ISSN:	0003-2670, 1873-4324, 1873-4324
Online Access:	Get full text
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