Using matrix-induced ion suppression combined with LC-MS/MS for quantification of trimethylamine-N-oxide, choline, carnitine and acetylcarnitine in dried blood spot samples

Recently, there has been significant interest in the influences of the human gut microbiota on many diseases, such as cardiovascular disease (CVD) and metabolic disorders. Trimethylamine N-oxide (TMAO) is one of the most frequently discussed gut-derived metabolites. Dried blood spot (DBS) sampling h...

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Veröffentlicht in:	Analytica chimica acta Jg. 1149; S. 338214
Hauptverfasser:	Lu, Wan-Hui, Chiu, Huai-Hsuan, Kuo, Han-Chun, Chen, Guan-Yuan, Chepyala, Divyabharathi, Kuo, Ching-Hua
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 08.03.2021
Schlagworte:	Acetylcarnitine Blood volume correction Carnitine Choline Chromatography, Liquid Dried blood spot (DBS) Dried Blood Spot Testing Humans Mass spectrometry Matrix induced ion suppression (MIIS) Methylamines Oxides Reproducibility of Results Tandem Mass Spectrometry Trimethylamine N-Oxide (TMAO) Matrix induced ion suppression (MIIS) Blood volume correction Dried blood spot (DBS) Trimethylamine N-Oxide (TMAO) Mass spectrometry
ISSN:	0003-2670, 1873-4324, 1873-4324
Online-Zugang:	Volltext
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