In Vivo Noninvasive Measurement of Young's Modulus of Elasticity in Human Eyes: A Feasibility Study
Abnormal ocular biomechanical properties may be important for understanding the risk of glaucoma. However, there are no clinical methods for measuring standard material properties in patients. In this feasibility study we demonstrated proof-of-principle for a novel method, ultrasound surface wave el...
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| Veröffentlicht in: | Journal of glaucoma Jg. 26; H. 11; S. 967 |
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01.11.2017
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| Abstract | Abnormal ocular biomechanical properties may be important for understanding the risk of glaucoma. However, there are no clinical methods for measuring standard material properties in patients. In this feasibility study we demonstrated proof-of-principle for a novel method, ultrasound surface wave elastography (USWE), to determine the in vivo Young's modulus of elasticity of corneas in normal human eyes.
In total, 20 eyes of 10 healthy subjects (mean age, 51.4±7.2; ±SD; range, 43 to 64 y) were studied. A spherical-tipped probe (3-mm diameter) was placed on closed eyelids and generated a gentle harmonic vibration at 100 Hz for 0.1 second. Wave speed propagation in the cornea was measured by USWE, and Young's modulus was calculated from the wave speed. Associations between Young's modulus and intraocular pressure (IOP), age, central corneal thickness, and axial length were explored by the Pearson correlation. Statistical significance was determined by using generalized estimating equation models to account for possible correlation between fellow eyes.
Mean IOP was 12.8±2.7 mm Hg. Mean wave speed in the cornea was 1.82±0.10 m/s. Young's modulus of elasticity was 696±113 kPa and was correlated with IOP (r=0.57; P=0.004), but none of the other variables (P>0.1).
USWE is a novel noninvasive technique for measuring ocular biomechanical properties. Corneal Young's modulus in normal eyes is associated with IOP, consistent with measurements in cadaver eyes. Further work is needed to determine elasticity in other ocular tissues, particularly the sclera, and if elasticity is altered in glaucoma patients. |
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| AbstractList | Abnormal ocular biomechanical properties may be important for understanding the risk of glaucoma. However, there are no clinical methods for measuring standard material properties in patients. In this feasibility study we demonstrated proof-of-principle for a novel method, ultrasound surface wave elastography (USWE), to determine the in vivo Young's modulus of elasticity of corneas in normal human eyes.
In total, 20 eyes of 10 healthy subjects (mean age, 51.4±7.2; ±SD; range, 43 to 64 y) were studied. A spherical-tipped probe (3-mm diameter) was placed on closed eyelids and generated a gentle harmonic vibration at 100 Hz for 0.1 second. Wave speed propagation in the cornea was measured by USWE, and Young's modulus was calculated from the wave speed. Associations between Young's modulus and intraocular pressure (IOP), age, central corneal thickness, and axial length were explored by the Pearson correlation. Statistical significance was determined by using generalized estimating equation models to account for possible correlation between fellow eyes.
Mean IOP was 12.8±2.7 mm Hg. Mean wave speed in the cornea was 1.82±0.10 m/s. Young's modulus of elasticity was 696±113 kPa and was correlated with IOP (r=0.57; P=0.004), but none of the other variables (P>0.1).
USWE is a novel noninvasive technique for measuring ocular biomechanical properties. Corneal Young's modulus in normal eyes is associated with IOP, consistent with measurements in cadaver eyes. Further work is needed to determine elasticity in other ocular tissues, particularly the sclera, and if elasticity is altered in glaucoma patients. Abnormal ocular biomechanical properties may be important for understanding the risk of glaucoma. However, there are no clinical methods for measuring standard material properties in patients. In this feasibility study we demonstrated proof-of-principle for a novel method, ultrasound surface wave elastography (USWE), to determine the in vivo Young's modulus of elasticity of corneas in normal human eyes.PURPOSEAbnormal ocular biomechanical properties may be important for understanding the risk of glaucoma. However, there are no clinical methods for measuring standard material properties in patients. In this feasibility study we demonstrated proof-of-principle for a novel method, ultrasound surface wave elastography (USWE), to determine the in vivo Young's modulus of elasticity of corneas in normal human eyes.In total, 20 eyes of 10 healthy subjects (mean age, 51.4±7.2; ±SD; range, 43 to 64 y) were studied. A spherical-tipped probe (3-mm diameter) was placed on closed eyelids and generated a gentle harmonic vibration at 100 Hz for 0.1 second. Wave speed propagation in the cornea was measured by USWE, and Young's modulus was calculated from the wave speed. Associations between Young's modulus and intraocular pressure (IOP), age, central corneal thickness, and axial length were explored by the Pearson correlation. Statistical significance was determined by using generalized estimating equation models to account for possible correlation between fellow eyes.METHODSIn total, 20 eyes of 10 healthy subjects (mean age, 51.4±7.2; ±SD; range, 43 to 64 y) were studied. A spherical-tipped probe (3-mm diameter) was placed on closed eyelids and generated a gentle harmonic vibration at 100 Hz for 0.1 second. Wave speed propagation in the cornea was measured by USWE, and Young's modulus was calculated from the wave speed. Associations between Young's modulus and intraocular pressure (IOP), age, central corneal thickness, and axial length were explored by the Pearson correlation. Statistical significance was determined by using generalized estimating equation models to account for possible correlation between fellow eyes.Mean IOP was 12.8±2.7 mm Hg. Mean wave speed in the cornea was 1.82±0.10 m/s. Young's modulus of elasticity was 696±113 kPa and was correlated with IOP (r=0.57; P=0.004), but none of the other variables (P>0.1).RESULTSMean IOP was 12.8±2.7 mm Hg. Mean wave speed in the cornea was 1.82±0.10 m/s. Young's modulus of elasticity was 696±113 kPa and was correlated with IOP (r=0.57; P=0.004), but none of the other variables (P>0.1).USWE is a novel noninvasive technique for measuring ocular biomechanical properties. Corneal Young's modulus in normal eyes is associated with IOP, consistent with measurements in cadaver eyes. Further work is needed to determine elasticity in other ocular tissues, particularly the sclera, and if elasticity is altered in glaucoma patients.CONCLUSIONSUSWE is a novel noninvasive technique for measuring ocular biomechanical properties. Corneal Young's modulus in normal eyes is associated with IOP, consistent with measurements in cadaver eyes. Further work is needed to determine elasticity in other ocular tissues, particularly the sclera, and if elasticity is altered in glaucoma patients. |
| Author | Zhang, Xiaoming Lin, Shuai-Chun Kazemi, Arash Pruet, Christopher M McLaren, Jay W Sit, Arthur J |
| Author_xml | – sequence: 1 givenname: Arthur J surname: Sit fullname: Sit, Arthur J organization: Departments of Ophthalmology†Radiology‡Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN – sequence: 2 givenname: Shuai-Chun surname: Lin fullname: Lin, Shuai-Chun – sequence: 3 givenname: Arash surname: Kazemi fullname: Kazemi, Arash – sequence: 4 givenname: Jay W surname: McLaren fullname: McLaren, Jay W – sequence: 5 givenname: Christopher M surname: Pruet fullname: Pruet, Christopher M – sequence: 6 givenname: Xiaoming surname: Zhang fullname: Zhang, Xiaoming |
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| References | 21768026 - IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Jul;58(7):1418-29 16060513 - IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Apr;52(4):642-52 23642371 - Ophthalmology. 2013 Aug;120(8):1533-40 20971489 - Ultrasonics. 2011 Apr;51(3):289-95 19423431 - IEEE Trans Med Imaging. 2009 Dec;28(12 ):1881-93 21600658 - Ophthalmology. 2011 Sep;118(9):1766-73 23800511 - Exp Eye Res. 2013 Oct;115:41-6 25819451 - Exp Eye Res. 2015 Apr;133:19-29 10782622 - J Glaucoma. 2000 Apr;9(2):134-42 21989723 - Invest Ophthalmol Vis Sci. 2011 Nov 21;52(12):9023-32 26098472 - Invest Ophthalmol Vis Sci. 2015 Jun;56(6):4053-60 23361513 - Invest Ophthalmol Vis Sci. 2013 Feb 19;54(2):1418-25 20800256 - Ultrasonics. 2011 Feb;51(2):157-64 17269246 - J Refract Surg. 2007 Jan;23(1):66-75 23031416 - J Biomech. 2012 Nov 15;45(16):2927-30 11024415 - Am J Ophthalmol. 2000 Oct;130(4):429-40 24938517 - Invest Ophthalmol Vis Sci. 2014 Jun 17;55(7):4490-5 19213632 - IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Jan;56(1):55-62 26094834 - Ophthalmic Physiol Opt. 2015 Jul;35(4):455-61 24823760 - Ophthalmology. 2014 Jan;121(1):134-41 20574009 - Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6514-8 18082889 - Ophthalmology. 2008 Jul;115(7):1123-1129.e3 18539936 - Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3919-26 16471432 - IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Jan;53(1):52-63 22266511 - Invest Ophthalmol Vis Sci. 2012 Feb 29;53(2):1050-7 22159012 - Invest Ophthalmol Vis Sci. 2012 Jan 20;53(1):185-90 20888282 - Med Eng Phys. 2011 Jan;33(1):31-7 19835874 - Exp Eye Res. 2010 Jan;90(1):168-83 18396276 - Exp Eye Res. 2008 May;86(5):783-90 25426312 - Biomed Opt Express. 2014 Oct 06;5(11):3807-21 16849178 - J R Soc Interface. 2005 Jun 22;2(3):177-85 21705084 - Ophthalmology. 2012 Mar;119(3):437-42 23182387 - J Mech Behav Biomed Mater. 2012 Dec;16:181-91 18189542 - J Acoust Soc Am. 2007 Nov;122(5):2522-5 17364730 - Curr Eye Res. 2007 Jan;32(1):11-9 1591207 - Refract Corneal Surg. 1992 Mar-Apr;8(2):127-38 22341914 - Ophthalmology. 2012 May;119(5):987-91 15671280 - Invest Ophthalmol Vis Sci. 2005 Feb;46(2):540-6 11581049 - Ophthalmology. 2001 Oct;108(10):1779-88 |
| References_xml | – reference: 22341914 - Ophthalmology. 2012 May;119(5):987-91 – reference: 23361513 - Invest Ophthalmol Vis Sci. 2013 Feb 19;54(2):1418-25 – reference: 24938517 - Invest Ophthalmol Vis Sci. 2014 Jun 17;55(7):4490-5 – reference: 15671280 - Invest Ophthalmol Vis Sci. 2005 Feb;46(2):540-6 – reference: 20888282 - Med Eng Phys. 2011 Jan;33(1):31-7 – reference: 23031416 - J Biomech. 2012 Nov 15;45(16):2927-30 – reference: 21705084 - Ophthalmology. 2012 Mar;119(3):437-42 – reference: 21989723 - Invest Ophthalmol Vis Sci. 2011 Nov 21;52(12):9023-32 – reference: 20574009 - Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6514-8 – reference: 19213632 - IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Jan;56(1):55-62 – reference: 24823760 - Ophthalmology. 2014 Jan;121(1):134-41 – reference: 17364730 - Curr Eye Res. 2007 Jan;32(1):11-9 – reference: 19835874 - Exp Eye Res. 2010 Jan;90(1):168-83 – reference: 18539936 - Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3919-26 – reference: 22159012 - Invest Ophthalmol Vis Sci. 2012 Jan 20;53(1):185-90 – reference: 16471432 - IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Jan;53(1):52-63 – reference: 26098472 - Invest Ophthalmol Vis Sci. 2015 Jun;56(6):4053-60 – reference: 20800256 - Ultrasonics. 2011 Feb;51(2):157-64 – reference: 11581049 - Ophthalmology. 2001 Oct;108(10):1779-88 – reference: 23800511 - Exp Eye Res. 2013 Oct;115:41-6 – reference: 26094834 - Ophthalmic Physiol Opt. 2015 Jul;35(4):455-61 – reference: 16060513 - IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Apr;52(4):642-52 – reference: 23642371 - Ophthalmology. 2013 Aug;120(8):1533-40 – reference: 20971489 - Ultrasonics. 2011 Apr;51(3):289-95 – reference: 23182387 - J Mech Behav Biomed Mater. 2012 Dec;16:181-91 – reference: 25819451 - Exp Eye Res. 2015 Apr;133:19-29 – reference: 25426312 - Biomed Opt Express. 2014 Oct 06;5(11):3807-21 – reference: 16849178 - J R Soc Interface. 2005 Jun 22;2(3):177-85 – reference: 22266511 - Invest Ophthalmol Vis Sci. 2012 Feb 29;53(2):1050-7 – reference: 11024415 - Am J Ophthalmol. 2000 Oct;130(4):429-40 – reference: 18082889 - Ophthalmology. 2008 Jul;115(7):1123-1129.e3 – reference: 21768026 - IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Jul;58(7):1418-29 – reference: 10782622 - J Glaucoma. 2000 Apr;9(2):134-42 – reference: 18189542 - J Acoust Soc Am. 2007 Nov;122(5):2522-5 – reference: 17269246 - J Refract Surg. 2007 Jan;23(1):66-75 – reference: 18396276 - Exp Eye Res. 2008 May;86(5):783-90 – reference: 19423431 - IEEE Trans Med Imaging. 2009 Dec;28(12 ):1881-93 – reference: 21600658 - Ophthalmology. 2011 Sep;118(9):1766-73 – reference: 1591207 - Refract Corneal Surg. 1992 Mar-Apr;8(2):127-38 |
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| SubjectTerms | Adult Biomechanical Phenomena Cornea - physiology Elastic Modulus - physiology Elasticity - physiology Elasticity Imaging Techniques - methods Feasibility Studies Female Healthy Volunteers Humans Intraocular Pressure Male Middle Aged Tonometry, Ocular |
| Title | In Vivo Noninvasive Measurement of Young's Modulus of Elasticity in Human Eyes: A Feasibility Study |
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