The aging heart

As the elderly segment of the world population increases, it is critical to understand the changes in cardiac structure and function during the normal aging process. In this review, we outline the key molecular pathways and cellular processes that underlie the phenotypic changes in the heart and vas...

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Vydané v:Clinical science (1979) Ročník 132; číslo 13; s. 1367
Hlavní autori: Obas, Vanessa, Vasan, Ramachandran S
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 16.07.2018
Predmet:
Aging - genetics
Aging - pathology
Aging - physiology
Autophagy - physiology
Heart - anatomy & histology
Heart - physiology
Humans
Insulin-Like Growth Factor Binding Protein 1 - physiology
Oxidative Stress - physiology
Signal Transduction - physiology
Telomere Shortening - physiology
Ventricular Remodeling - physiology
epidemiology
myocardium
aging
ISSN:1470-8736, 1470-8736
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Popis
Shrnutí:As the elderly segment of the world population increases, it is critical to understand the changes in cardiac structure and function during the normal aging process. In this review, we outline the key molecular pathways and cellular processes that underlie the phenotypic changes in the heart and vasculature that accompany aging. Reduced autophagy, increased mitochondrial oxidative stress, telomere attrition, altered signaling in insulin-like growth factor, growth differentiation factor 11, and 5'- AMP-activated protein kinase pathways are among the key molecular mechanisms underlying cardiac aging. Aging promotes structural and functional changes in the atria, ventricles, valves, myocardium, pericardium, the cardiac conduction system, and the vasculature. We highlight the factors known to accelerate and attenuate the intrinsic aging of the heart and vessels in addition to potential preventive and therapeutic avenues. A greater understanding of the processes involved in cardiac aging may facilitate our ability to mitigate the escalating burden of CVD in older individuals and promote healthy cardiac aging.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1470-8736
1470-8736
DOI:10.1042/CS20171156