A systematic review on the current status of PSMA-targeted imaging and radioligand therapy

Prostate specific membrane antigen (PSMA) has been the subject of several studies in recent decades as a promising molecular target for prostate cancer (PCa), in fact it is considered an excellent molecular target for both PCa imaging (both for staging and follow-up), by means of PET/CT and for radi...

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Vydáno v:European journal of medicinal chemistry Ročník 263; s. 115966
Hlavní autoři: Capasso, Giuseppe, Stefanucci, Azzurra, Tolomeo, Anna
Médium: Journal Article
Jazyk:angličtina
Vydáno: France 05.01.2024
Témata:
Gallium Radioisotopes
Humans
Male
Positron Emission Tomography Computed Tomography - methods
Precision Medicine
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - radiotherapy
Radiopharmaceuticals - therapeutic use
Radioligand Therapy
Prostate cancer imaging
Prostate specific membrane antigen
Positron emission tomography
Theranostics
ISSN:0223-5234, 1768-3254, 1768-3254
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Shrnutí:Prostate specific membrane antigen (PSMA) has been the subject of several studies in recent decades as a promising molecular target for prostate cancer (PCa), in fact it is considered an excellent molecular target for both PCa imaging (both for staging and follow-up), by means of PET/CT and for radioligand therapy. Its interesting molecular features have enabled the development of a new diagnostic and therapeutic approach for PCa, called "theranostics." Considering the abundance of PSMA-based probes that have appeared so far in the literature, the present work focuses the attention on radiopharmaceuticals with increasing clinical application, highlighting advantages and disadvantages in terms of different metabolization and excretion processes, pharmacokinetic, binding affinity and variable internalization rate, tumor-to-background ratio, residence times and toxicity profile.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
ObjectType-Review-4
content type line 23
ISSN:0223-5234
1768-3254
1768-3254
DOI:10.1016/j.ejmech.2023.115966