Phagocyte NADPH oxidase and specific immunity

The phagocyte NADPH oxidase NOX2 produces reactive oxygen species (ROS) and is a well-known player in host defence. However, there is also increasing evidence for a regulatory role of NOX2 in adaptive immunity. Deficiency in phagocyte NADPH oxidase causes chronic granulomatous disease (CGD) in human...

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Veröffentlicht in:	Clinical science (1979) Jg. 128; H. 10; S. 635 - 648
Hauptverfasser:	Cachat, Julien, Deffert, Christine, Hugues, Stephanie, Krause, Karl-Heinz
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.05.2015
Schlagworte:	Adaptive Immunity - immunology Animals Granulomatous Disease, Chronic - immunology Granulomatous Disease, Chronic - metabolism Humans Immunity, Innate - immunology Lymphocytes - cytology Lymphocytes - metabolism Membrane Glycoproteins - deficiency Membrane Glycoproteins - immunology Mice Myelin-Oligodendrocyte Glycoprotein - immunology NADPH Oxidase 2 NADPH Oxidases - deficiency NADPH Oxidases - immunology Phagocytes - enzymology Phagocytes - immunology Reactive Oxygen Species - metabolism Signal Transduction - immunology
ISSN:	1470-8736
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