Head over heels but I forget why: Disruptive functional connectivity in older adult fallers with mild cognitive impairment
•Fallers with MCI had a greater level of disruptive DMN-SMN connectivity.•DMN-SMN connectivity increased linearly from Fallers only – MCI only – Fallers + MCI.•Fallers with MCI have significantly greater postural sway than those without MCI.•Postural sway increased linearly from Fallers only - MCI o...
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| Published in: | Behavioural brain research Vol. 376; p. 112104 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
30.12.2019
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| ISSN: | 0166-4328, 1872-7549, 1872-7549 |
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| Abstract | •Fallers with MCI had a greater level of disruptive DMN-SMN connectivity.•DMN-SMN connectivity increased linearly from Fallers only – MCI only – Fallers + MCI.•Fallers with MCI have significantly greater postural sway than those without MCI.•Postural sway increased linearly from Fallers only - MCI only - Fallers + MCI.
Disrupted functional connectivity has been highlighted as a neural mechanism by which impaired cognitive function and mobility co-exist in older adults with mild cognitive impairment (MCI).
The objective of this study was to determine the independent and combined effects of MCI and faller status on functional connectivity of three functional networks: default mode network (DMN), fronto-parietal network (FPN) and sensorimotor network (SMN) between 4 groups of older adults: 1) Healthy; 2) MCI without Falls; 3) Fallers without MCI; and 4) Fallers with MCI.
Sixty-six adults aged 70–80 years old were included. Cognition was assessed using: 1) cognitive dual task; 2) Stroop Colour-Word Test; 3) Trail Making Tests (TMT); and 4) Digit Symbol Substitution Test (DSST). Postural sway was assessed with eyes opened and standing on the floor. Functional connectivity was measured using fMRI while performing a finger-tapping task.
Differences in DMN-SMN connectivity were found for Fallers with MCI vs Fallers without MCI (p = .001). Fallers with MCI had significantly greater postural sway than the other groups. Both DMN-SMN connectivity (p = .03) and postural sway (p = .001) increased in a significantly linear fashion from Fallers without MCI, to MCI without Falls, to Fallers with MCI. Participants with MCI performed significantly worse on the DSST (p = .003) and TMT (p = .007) than those without MCI.
Aberrant DMN-SMN connectivity may underlie reduced postural stability. Having both impaired cognition and mobility is associated with a greater level of disruptive DMN-SMN connectivity and increased postural sway than singular impairment. |
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| AbstractList | Disrupted functional connectivity has been highlighted as a neural mechanism by which impaired cognitive function and mobility co-exist in older adults with mild cognitive impairment (MCI). The objective of this study was to determine the independent and combined effects of MCI and faller status on functional connectivity of three functional networks: default mode network (DMN), fronto-parietal network (FPN) and sensorimotor network (SMN) between 4 groups of older adults: 1) Healthy; 2) MCI without Falls; 3) Fallers without MCI; and 4) Fallers with MCI.Disrupted functional connectivity has been highlighted as a neural mechanism by which impaired cognitive function and mobility co-exist in older adults with mild cognitive impairment (MCI). The objective of this study was to determine the independent and combined effects of MCI and faller status on functional connectivity of three functional networks: default mode network (DMN), fronto-parietal network (FPN) and sensorimotor network (SMN) between 4 groups of older adults: 1) Healthy; 2) MCI without Falls; 3) Fallers without MCI; and 4) Fallers with MCI.Sixty-six adults aged 70-80 years old were included. Cognition was assessed using: 1) cognitive dual task; 2) Stroop Colour-Word Test; 3) Trail Making Tests (TMT); and 4) Digit Symbol Substitution Test (DSST). Postural sway was assessed with eyes opened and standing on the floor. Functional connectivity was measured using fMRI while performing a finger-tapping task.METHODSSixty-six adults aged 70-80 years old were included. Cognition was assessed using: 1) cognitive dual task; 2) Stroop Colour-Word Test; 3) Trail Making Tests (TMT); and 4) Digit Symbol Substitution Test (DSST). Postural sway was assessed with eyes opened and standing on the floor. Functional connectivity was measured using fMRI while performing a finger-tapping task.Differences in DMN-SMN connectivity were found for Fallers with MCI vs Fallers without MCI (p = .001). Fallers with MCI had significantly greater postural sway than the other groups. Both DMN-SMN connectivity (p = .03) and postural sway (p = .001) increased in a significantly linear fashion from Fallers without MCI, to MCI without Falls, to Fallers with MCI. Participants with MCI performed significantly worse on the DSST (p = .003) and TMT (p = .007) than those without MCI.RESULTSDifferences in DMN-SMN connectivity were found for Fallers with MCI vs Fallers without MCI (p = .001). Fallers with MCI had significantly greater postural sway than the other groups. Both DMN-SMN connectivity (p = .03) and postural sway (p = .001) increased in a significantly linear fashion from Fallers without MCI, to MCI without Falls, to Fallers with MCI. Participants with MCI performed significantly worse on the DSST (p = .003) and TMT (p = .007) than those without MCI.Aberrant DMN-SMN connectivity may underlie reduced postural stability. Having both impaired cognition and mobility is associated with a greater level of disruptive DMN-SMN connectivity and increased postural sway than singular impairment.CONCLUSIONAberrant DMN-SMN connectivity may underlie reduced postural stability. Having both impaired cognition and mobility is associated with a greater level of disruptive DMN-SMN connectivity and increased postural sway than singular impairment. Disrupted functional connectivity has been highlighted as a neural mechanism by which impaired cognitive function and mobility co-exist in older adults with mild cognitive impairment (MCI). The objective of this study was to determine the independent and combined effects of MCI and faller status on functional connectivity of three functional networks: default mode network (DMN), fronto-parietal network (FPN) and sensorimotor network (SMN) between 4 groups of older adults: 1) Healthy; 2) MCI without Falls; 3) Fallers without MCI; and 4) Fallers with MCI. Sixty-six adults aged 70-80 years old were included. Cognition was assessed using: 1) cognitive dual task; 2) Stroop Colour-Word Test; 3) Trail Making Tests (TMT); and 4) Digit Symbol Substitution Test (DSST). Postural sway was assessed with eyes opened and standing on the floor. Functional connectivity was measured using fMRI while performing a finger-tapping task. Differences in DMN-SMN connectivity were found for Fallers with MCI vs Fallers without MCI (p = .001). Fallers with MCI had significantly greater postural sway than the other groups. Both DMN-SMN connectivity (p = .03) and postural sway (p = .001) increased in a significantly linear fashion from Fallers without MCI, to MCI without Falls, to Fallers with MCI. Participants with MCI performed significantly worse on the DSST (p = .003) and TMT (p = .007) than those without MCI. Aberrant DMN-SMN connectivity may underlie reduced postural stability. Having both impaired cognition and mobility is associated with a greater level of disruptive DMN-SMN connectivity and increased postural sway than singular impairment. •Fallers with MCI had a greater level of disruptive DMN-SMN connectivity.•DMN-SMN connectivity increased linearly from Fallers only – MCI only – Fallers + MCI.•Fallers with MCI have significantly greater postural sway than those without MCI.•Postural sway increased linearly from Fallers only - MCI only - Fallers + MCI. Disrupted functional connectivity has been highlighted as a neural mechanism by which impaired cognitive function and mobility co-exist in older adults with mild cognitive impairment (MCI). The objective of this study was to determine the independent and combined effects of MCI and faller status on functional connectivity of three functional networks: default mode network (DMN), fronto-parietal network (FPN) and sensorimotor network (SMN) between 4 groups of older adults: 1) Healthy; 2) MCI without Falls; 3) Fallers without MCI; and 4) Fallers with MCI. Sixty-six adults aged 70–80 years old were included. Cognition was assessed using: 1) cognitive dual task; 2) Stroop Colour-Word Test; 3) Trail Making Tests (TMT); and 4) Digit Symbol Substitution Test (DSST). Postural sway was assessed with eyes opened and standing on the floor. Functional connectivity was measured using fMRI while performing a finger-tapping task. Differences in DMN-SMN connectivity were found for Fallers with MCI vs Fallers without MCI (p = .001). Fallers with MCI had significantly greater postural sway than the other groups. Both DMN-SMN connectivity (p = .03) and postural sway (p = .001) increased in a significantly linear fashion from Fallers without MCI, to MCI without Falls, to Fallers with MCI. Participants with MCI performed significantly worse on the DSST (p = .003) and TMT (p = .007) than those without MCI. Aberrant DMN-SMN connectivity may underlie reduced postural stability. Having both impaired cognition and mobility is associated with a greater level of disruptive DMN-SMN connectivity and increased postural sway than singular impairment. |
| ArticleNumber | 112104 |
| Author | Hsu, Chun Liang Beauchet, Olivier Best, John R. Liu-Ambrose, Teresa Crockett, Rachel A. |
| Author_xml | – sequence: 1 givenname: Rachel A. surname: Crockett fullname: Crockett, Rachel A. organization: Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada – sequence: 2 givenname: Chun Liang surname: Hsu fullname: Hsu, Chun Liang organization: Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada – sequence: 3 givenname: John R. surname: Best fullname: Best, John R. organization: Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada – sequence: 4 givenname: Olivier surname: Beauchet fullname: Beauchet, Olivier organization: Faculty of Medicine, McGill University, Montreal, QC, Canada – sequence: 5 givenname: Teresa surname: Liu-Ambrose fullname: Liu-Ambrose, Teresa email: teresa.ambrose@ubc.ca organization: Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31325516$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1146/annurev.psych.59.103006.093656 10.1016/0028-3932(71)90067-4 10.1046/j.1532-5415.2003.51404.x 10.1093/cercor/bhj036 10.1016/j.neuron.2007.10.038 10.1196/annals.1440.011 10.1111/j.1532-5415.2008.01758.x 10.4061/2011/535816 10.1093/gerona/glt002 10.1186/1743-0003-11-14 10.2522/ptj.20080117 10.1093/gerona/gls191 10.1080/01688639508405132 10.1001/archneur.56.3.303 10.1073/pnas.98.2.676 10.1016/j.conb.2005.03.016 10.3233/JAD-142547 10.1093/cercor/bhm155 10.1371/journal.pone.0093673 10.1523/JNEUROSCI.2177-05.2005 10.1016/0022-3956(75)90026-6 10.1093/ptj/83.3.237 10.3389/fnagi.2017.00423 10.1093/gerona/61.8.832 10.1111/j.1532-5415.2010.03017.x 10.1073/pnas.0800005105 10.1056/NEJM198812293192604 10.1056/NEJMoa020441 10.1111/j.1532-5415.2005.53221.x 10.1162/jocn.2006.18.2.227 10.1001/jama.1989.03420180087036 10.1038/nrn755 10.1016/j.neuron.2012.03.038 10.1016/j.neurobiolaging.2008.06.015 10.1097/NPT.0b013e3182462ea6 10.1073/pnas.2235925100 10.1093/ageing/afi218 10.1001/archneurol.2010.159 10.1212/WNL.0000000000000717 10.1093/biomet/68.3.647 10.1016/j.exger.2018.06.002 10.1093/cercor/bhh086 |
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| Keywords | Falls Aberrant functional connectivity Mild cognitive impairment Postural sway |
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| References | Hausdorff, Buchman (bib0045) 2013; 68 Persson (bib0065) 2006; 16 Buckner (bib0130) 2005; 25 van Doorn (bib0010) 2003; 51 Hsu (bib0150) 2014; 9 Hauer (bib0190) 2006; 35 Buckner, Andrews-Hanna, Schacter (bib0085) 2008; 1124 Tinetti, Speechley, Ginter (bib0015) 1988; 319 Verghese (bib0040) 2002; 347 Doi (bib0165) 2018; 110 Verghese (bib0025) 2008; 56 Oldfield (bib0175) 1971; 9 Nasreddine (bib0180) 2005; 53 Choo (bib0135) 2010; 31 Verghese (bib0155) 2013; 68 Liu-Ambrose (bib0220) 2006; 61 Liu-Ambrose (bib0030) 2008; 88 Lau, Gwin, Ferris (bib0230) 2014; 11 Solodkin (bib0105) 2004; 14 Vidoni (bib0070) 2012; 36 Mevel (bib0125) 2011; 2011 Lezak (bib0210) 1995 Voss (bib0075) 2010; 2 Gardini (bib0120) 2015; 45 Davis (bib0140) 2008; 18 Andrews-Hanna (bib0050) 2007; 56 Sridharan, Levitin, Menon (bib0095) 2008; 105 Folstein, Folstein, McHugh (bib0170) 1975; 12 Spreen, Strauss (bib0205) 1998 Verghese (bib0160) 2014; 83 Reuter-Lorenz, Lustig (bib0055) 2005; 15 Crockett (bib0145) 2017; 9 Organisation, W.H (bib0005) 2018 Konishi (bib0225) 1981; 68 Grady (bib0110) 2006; 18 Buracchio (bib0035) 2010; 67 Park, Reuter-Lorenz (bib0060) 2009; 60 Lustig (bib0115) 2003; 100 Wymbs (bib0100) 2012; 74 Lord, Menz, Tiedemann (bib0215) 2003; 83 Delbaere (bib0185) 2010; 58 Graf, Uttl, Tuokko (bib0200) 1995; 17 Corbetta, Shulman (bib0090) 2002; 3 Nevitt (bib0195) 1989; 261 Petersen (bib0020) 1999; 56 Raichle (bib0080) 2001; 98 Corbetta (10.1016/j.bbr.2019.112104_bib0090) 2002; 3 Liu-Ambrose (10.1016/j.bbr.2019.112104_bib0030) 2008; 88 Buckner (10.1016/j.bbr.2019.112104_bib0130) 2005; 25 Konishi (10.1016/j.bbr.2019.112104_bib0225) 1981; 68 Buckner (10.1016/j.bbr.2019.112104_bib0085) 2008; 1124 Spreen (10.1016/j.bbr.2019.112104_bib0205) 1998 Verghese (10.1016/j.bbr.2019.112104_bib0040) 2002; 347 Lustig (10.1016/j.bbr.2019.112104_bib0115) 2003; 100 Nevitt (10.1016/j.bbr.2019.112104_bib0195) 1989; 261 Verghese (10.1016/j.bbr.2019.112104_bib0025) 2008; 56 Hausdorff (10.1016/j.bbr.2019.112104_bib0045) 2013; 68 Lezak (10.1016/j.bbr.2019.112104_bib0210) 1995 Crockett (10.1016/j.bbr.2019.112104_bib0145) 2017; 9 Lord (10.1016/j.bbr.2019.112104_bib0215) 2003; 83 van Doorn (10.1016/j.bbr.2019.112104_bib0010) 2003; 51 Park (10.1016/j.bbr.2019.112104_bib0060) 2009; 60 Verghese (10.1016/j.bbr.2019.112104_bib0160) 2014; 83 Organisation, W.H (10.1016/j.bbr.2019.112104_bib0005) 2018 Vidoni (10.1016/j.bbr.2019.112104_bib0070) 2012; 36 Petersen (10.1016/j.bbr.2019.112104_bib0020) 1999; 56 Gardini (10.1016/j.bbr.2019.112104_bib0120) 2015; 45 Wymbs (10.1016/j.bbr.2019.112104_bib0100) 2012; 74 Davis (10.1016/j.bbr.2019.112104_bib0140) 2008; 18 Oldfield (10.1016/j.bbr.2019.112104_bib0175) 1971; 9 Andrews-Hanna (10.1016/j.bbr.2019.112104_bib0050) 2007; 56 Verghese (10.1016/j.bbr.2019.112104_bib0155) 2013; 68 Sridharan (10.1016/j.bbr.2019.112104_bib0095) 2008; 105 Nasreddine (10.1016/j.bbr.2019.112104_bib0180) 2005; 53 Raichle (10.1016/j.bbr.2019.112104_bib0080) 2001; 98 Choo (10.1016/j.bbr.2019.112104_bib0135) 2010; 31 Hauer (10.1016/j.bbr.2019.112104_bib0190) 2006; 35 Delbaere (10.1016/j.bbr.2019.112104_bib0185) 2010; 58 Liu-Ambrose (10.1016/j.bbr.2019.112104_bib0220) 2006; 61 Hsu (10.1016/j.bbr.2019.112104_bib0150) 2014; 9 Grady (10.1016/j.bbr.2019.112104_bib0110) 2006; 18 Lau (10.1016/j.bbr.2019.112104_bib0230) 2014; 11 Doi (10.1016/j.bbr.2019.112104_bib0165) 2018; 110 Tinetti (10.1016/j.bbr.2019.112104_bib0015) 1988; 319 Voss (10.1016/j.bbr.2019.112104_bib0075) 2010; 2 Buracchio (10.1016/j.bbr.2019.112104_bib0035) 2010; 67 Persson (10.1016/j.bbr.2019.112104_bib0065) 2006; 16 Mevel (10.1016/j.bbr.2019.112104_bib0125) 2011; 2011 Solodkin (10.1016/j.bbr.2019.112104_bib0105) 2004; 14 Graf (10.1016/j.bbr.2019.112104_bib0200) 1995; 17 Reuter-Lorenz (10.1016/j.bbr.2019.112104_bib0055) 2005; 15 Folstein (10.1016/j.bbr.2019.112104_bib0170) 1975; 12 |
| References_xml | – volume: 347 start-page: 1761 year: 2002 end-page: 1768 ident: bib0040 article-title: Abnormality of gait as a predictor of non-Alzheimer’s dementia publication-title: N. Engl. J. Med. – volume: 3 start-page: 201 year: 2002 end-page: 215 ident: bib0090 article-title: Control of goal-directed and stimulus-driven attention in the brain publication-title: Nat. Rev. Neurosci. – volume: 68 start-page: 412 year: 2013 end-page: 418 ident: bib0155 article-title: Motoric cognitive risk syndrome and the risk of dementia publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 12 start-page: 189 year: 1975 end-page: 198 ident: bib0170 article-title: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician publication-title: J. Psychiatr. Res. – volume: 261 start-page: 2663 year: 1989 end-page: 2668 ident: bib0195 article-title: Risk factors for recurrent nonsyncopal falls. A prospective study publication-title: JAMA – volume: 45 start-page: 457 year: 2015 end-page: 470 ident: bib0120 article-title: Increased functional connectivity in the default mode network in mild cognitive impairment: a maladaptive compensatory mechanism associated with poor semantic memory performance publication-title: J. Alzheimers Dis. – volume: 36 start-page: 8 year: 2012 end-page: 16 ident: bib0070 article-title: Evidence of altered corticomotor system connectivity in early-stage Alzheimer’s disease publication-title: J. Neurol. Phys. Ther. – volume: 2 year: 2010 ident: bib0075 article-title: Plasticity of brain networks in a randomized intervention trial of exercise training in older adults publication-title: Front. Aging Neurosci. – volume: 98 start-page: 676 year: 2001 end-page: 682 ident: bib0080 article-title: A default mode of brain function publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 2011 start-page: 535816 year: 2011 ident: bib0125 article-title: The default mode network in healthy aging and Alzheimer’s disease publication-title: Int. J. Alzheimers Dis. – volume: 68 start-page: 647 year: 1981 end-page: 651 ident: bib0225 article-title: Normalizing transformations of some statistics in multivariate analysis publication-title: Biometrika – volume: 35 start-page: 5 year: 2006 end-page: 10 ident: bib0190 article-title: Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials publication-title: Age Ageing – volume: 18 start-page: 1201 year: 2008 end-page: 1209 ident: bib0140 article-title: Que PASA? The posterior-anterior shift in aging publication-title: Cereb. Cortex – volume: 14 start-page: 1246 year: 2004 end-page: 1255 ident: bib0105 article-title: Fine modulation in network activation during motor execution and motor imagery publication-title: Cereb. Cortex – volume: 9 start-page: e93673 year: 2014 ident: bib0150 article-title: Disruptions in brain networks of older fallers are associated with subsequent cognitive decline: a 12-month prospective exploratory study publication-title: PLoS One – volume: 18 start-page: 227 year: 2006 end-page: 241 ident: bib0110 article-title: Age-related changes in brain activity across the adult lifespan publication-title: J. Cogn. Neurosci. – year: 1995 ident: bib0210 article-title: Neuropsychological Assessment – year: 2018 ident: bib0005 article-title: WHO Global Report on Falls Prevention in Older Age – volume: 51 start-page: 1213 year: 2003 end-page: 1218 ident: bib0010 article-title: Dementia as a risk factor for falls and fall injuries among nursing home residents publication-title: J. Am. Geriatr. Soc. – volume: 17 start-page: 390 year: 1995 end-page: 415 ident: bib0200 article-title: Color- and picture-word Stroop tests: performance changes in old age publication-title: J. Clin. Exp. Neuropsychol. – volume: 68 start-page: 409 year: 2013 end-page: 411 ident: bib0045 article-title: What links gait speed and MCI with dementia? A fresh look at the association between motor and cognitive function publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 9 start-page: 423 year: 2017 ident: bib0145 article-title: Resting state default mode network connectivity, dual task performance, gait speed, and postural sway in older adults with mild cognitive impairment publication-title: Front. Aging Neurosci. – volume: 110 start-page: 146 year: 2018 end-page: 150 ident: bib0165 article-title: Combined effects of mild cognitive impairment and slow gait on risk of dementia publication-title: Exp. Gerontol. – volume: 25 start-page: 7709 year: 2005 end-page: 7717 ident: bib0130 article-title: Molecular, structural, and functional characterization of Alzheimer’s disease: evidence for a relationship between default activity, amyloid, and memory publication-title: J. Neurosci. – volume: 56 start-page: 1244 year: 2008 end-page: 1251 ident: bib0025 article-title: Gait dysfunction in mild cognitive impairment syndromes publication-title: J. Am. Geriatr. Soc. – volume: 61 start-page: 832 year: 2006 end-page: 838 ident: bib0220 article-title: Falls-related self-efficacy is independently associated with balance and mobility in older women with low bone mass publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 83 start-page: 237 year: 2003 end-page: 252 ident: bib0215 article-title: A physiological profile approach to falls risk assessment and prevention publication-title: Phys. Ther. – volume: 31 start-page: 772 year: 2010 end-page: 779 ident: bib0135 article-title: Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer’s disease publication-title: Neurobiol. Aging – volume: 88 start-page: 1482 year: 2008 end-page: 1491 ident: bib0030 article-title: Increased risk of falling in older community-dwelling women with mild cognitive impairment publication-title: Phys. Ther. – volume: 105 start-page: 12569 year: 2008 end-page: 12574 ident: bib0095 article-title: A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 9 start-page: 97 year: 1971 end-page: 113 ident: bib0175 article-title: The assessment and analysis of handedness: the Edinburgh inventory publication-title: Neuropsychologia – volume: 67 start-page: 980 year: 2010 end-page: 986 ident: bib0035 article-title: The trajectory of gait speed preceding mild cognitive impairment publication-title: Arch. Neurol. – year: 1998 ident: bib0205 article-title: A Compendium of Neurological Tests – volume: 53 start-page: 695 year: 2005 end-page: 699 ident: bib0180 article-title: The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment publication-title: J. Am. Geriatr. Soc. – volume: 60 start-page: 173 year: 2009 end-page: 196 ident: bib0060 article-title: The adaptive brain: aging and neurocognitive scaffolding publication-title: Annu. Rev. Psychol. – volume: 58 start-page: 1679 year: 2010 end-page: 1685 ident: bib0185 article-title: A multifactorial approach to understanding fall risk in older people publication-title: J. Am. Geriatr. Soc. – volume: 319 start-page: 1701 year: 1988 end-page: 1707 ident: bib0015 article-title: Risk factors for falls among elderly persons living in the community publication-title: N. Engl. J. Med. – volume: 15 start-page: 245 year: 2005 end-page: 251 ident: bib0055 article-title: Brain aging: reorganizing discoveries about the aging mind publication-title: Curr. Opin. Neurobiol. – volume: 56 start-page: 303 year: 1999 end-page: 308 ident: bib0020 article-title: Mild cognitive impairment: clinical characterization and outcome publication-title: Arch. Neurol. – volume: 56 start-page: 924 year: 2007 end-page: 935 ident: bib0050 article-title: Disruption of large-scale brain systems in advanced aging publication-title: Neuron – volume: 74 start-page: 936 year: 2012 end-page: 946 ident: bib0100 article-title: Differential recruitment of the sensorimotor putamen and frontoparietal cortex during motor chunking in humans publication-title: Neuron – volume: 11 start-page: 14 year: 2014 ident: bib0230 article-title: Walking reduces sensorimotor network connectivity compared to standing publication-title: J. Neuroeng. Rehabil. – volume: 1124 start-page: 1 year: 2008 end-page: 38 ident: bib0085 article-title: The brain’s default network: anatomy, function, and relevance to disease publication-title: Ann. N. Y. Acad. Sci. – volume: 83 start-page: 718 year: 2014 end-page: 726 ident: bib0160 article-title: Motoric cognitive risk syndrome: multicountry prevalence and dementia risk publication-title: Neurology – volume: 16 start-page: 907 year: 2006 end-page: 915 ident: bib0065 article-title: Structure-function correlates of cognitive decline in aging publication-title: Cereb. Cortex – volume: 100 start-page: 14504 year: 2003 end-page: 14509 ident: bib0115 article-title: Functional deactivations: change with age and dementia of the Alzheimer type publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 60 start-page: 173 year: 2009 ident: 10.1016/j.bbr.2019.112104_bib0060 article-title: The adaptive brain: aging and neurocognitive scaffolding publication-title: Annu. Rev. Psychol. doi: 10.1146/annurev.psych.59.103006.093656 – volume: 9 start-page: 97 issue: 1 year: 1971 ident: 10.1016/j.bbr.2019.112104_bib0175 article-title: The assessment and analysis of handedness: the Edinburgh inventory publication-title: Neuropsychologia doi: 10.1016/0028-3932(71)90067-4 – volume: 51 start-page: 1213 issue: 9 year: 2003 ident: 10.1016/j.bbr.2019.112104_bib0010 article-title: Dementia as a risk factor for falls and fall injuries among nursing home residents publication-title: J. Am. Geriatr. Soc. doi: 10.1046/j.1532-5415.2003.51404.x – volume: 16 start-page: 907 issue: 7 year: 2006 ident: 10.1016/j.bbr.2019.112104_bib0065 article-title: Structure-function correlates of cognitive decline in aging publication-title: Cereb. Cortex doi: 10.1093/cercor/bhj036 – volume: 56 start-page: 924 issue: 5 year: 2007 ident: 10.1016/j.bbr.2019.112104_bib0050 article-title: Disruption of large-scale brain systems in advanced aging publication-title: Neuron doi: 10.1016/j.neuron.2007.10.038 – volume: 1124 start-page: 1 year: 2008 ident: 10.1016/j.bbr.2019.112104_bib0085 article-title: The brain’s default network: anatomy, function, and relevance to disease publication-title: Ann. N. Y. Acad. Sci. doi: 10.1196/annals.1440.011 – volume: 56 start-page: 1244 issue: 7 year: 2008 ident: 10.1016/j.bbr.2019.112104_bib0025 article-title: Gait dysfunction in mild cognitive impairment syndromes publication-title: J. Am. Geriatr. Soc. doi: 10.1111/j.1532-5415.2008.01758.x – volume: 2011 start-page: 535816 year: 2011 ident: 10.1016/j.bbr.2019.112104_bib0125 article-title: The default mode network in healthy aging and Alzheimer’s disease publication-title: Int. J. Alzheimers Dis. doi: 10.4061/2011/535816 – volume: 68 start-page: 409 issue: 4 year: 2013 ident: 10.1016/j.bbr.2019.112104_bib0045 article-title: What links gait speed and MCI with dementia? A fresh look at the association between motor and cognitive function publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glt002 – volume: 11 start-page: 14 year: 2014 ident: 10.1016/j.bbr.2019.112104_bib0230 article-title: Walking reduces sensorimotor network connectivity compared to standing publication-title: J. Neuroeng. Rehabil. doi: 10.1186/1743-0003-11-14 – volume: 88 start-page: 1482 issue: 12 year: 2008 ident: 10.1016/j.bbr.2019.112104_bib0030 article-title: Increased risk of falling in older community-dwelling women with mild cognitive impairment publication-title: Phys. Ther. doi: 10.2522/ptj.20080117 – volume: 68 start-page: 412 issue: 4 year: 2013 ident: 10.1016/j.bbr.2019.112104_bib0155 article-title: Motoric cognitive risk syndrome and the risk of dementia publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/gls191 – volume: 17 start-page: 390 issue: 3 year: 1995 ident: 10.1016/j.bbr.2019.112104_bib0200 article-title: Color- and picture-word Stroop tests: performance changes in old age publication-title: J. Clin. Exp. Neuropsychol. doi: 10.1080/01688639508405132 – year: 2018 ident: 10.1016/j.bbr.2019.112104_bib0005 – volume: 56 start-page: 303 issue: 3 year: 1999 ident: 10.1016/j.bbr.2019.112104_bib0020 article-title: Mild cognitive impairment: clinical characterization and outcome publication-title: Arch. Neurol. doi: 10.1001/archneur.56.3.303 – volume: 98 start-page: 676 issue: 2 year: 2001 ident: 10.1016/j.bbr.2019.112104_bib0080 article-title: A default mode of brain function publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.98.2.676 – volume: 15 start-page: 245 issue: 2 year: 2005 ident: 10.1016/j.bbr.2019.112104_bib0055 article-title: Brain aging: reorganizing discoveries about the aging mind publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2005.03.016 – volume: 45 start-page: 457 issue: 2 year: 2015 ident: 10.1016/j.bbr.2019.112104_bib0120 article-title: Increased functional connectivity in the default mode network in mild cognitive impairment: a maladaptive compensatory mechanism associated with poor semantic memory performance publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-142547 – year: 1998 ident: 10.1016/j.bbr.2019.112104_bib0205 – volume: 18 start-page: 1201 issue: 5 year: 2008 ident: 10.1016/j.bbr.2019.112104_bib0140 article-title: Que PASA? The posterior-anterior shift in aging publication-title: Cereb. Cortex doi: 10.1093/cercor/bhm155 – volume: 9 start-page: e93673 issue: 4 year: 2014 ident: 10.1016/j.bbr.2019.112104_bib0150 article-title: Disruptions in brain networks of older fallers are associated with subsequent cognitive decline: a 12-month prospective exploratory study publication-title: PLoS One doi: 10.1371/journal.pone.0093673 – volume: 25 start-page: 7709 issue: 34 year: 2005 ident: 10.1016/j.bbr.2019.112104_bib0130 article-title: Molecular, structural, and functional characterization of Alzheimer’s disease: evidence for a relationship between default activity, amyloid, and memory publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2177-05.2005 – volume: 12 start-page: 189 issue: 3 year: 1975 ident: 10.1016/j.bbr.2019.112104_bib0170 article-title: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician publication-title: J. Psychiatr. Res. doi: 10.1016/0022-3956(75)90026-6 – volume: 83 start-page: 237 issue: 3 year: 2003 ident: 10.1016/j.bbr.2019.112104_bib0215 article-title: A physiological profile approach to falls risk assessment and prevention publication-title: Phys. Ther. doi: 10.1093/ptj/83.3.237 – volume: 9 start-page: 423 year: 2017 ident: 10.1016/j.bbr.2019.112104_bib0145 article-title: Resting state default mode network connectivity, dual task performance, gait speed, and postural sway in older adults with mild cognitive impairment publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2017.00423 – volume: 61 start-page: 832 issue: 8 year: 2006 ident: 10.1016/j.bbr.2019.112104_bib0220 article-title: Falls-related self-efficacy is independently associated with balance and mobility in older women with low bone mass publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/61.8.832 – volume: 58 start-page: 1679 issue: 9 year: 2010 ident: 10.1016/j.bbr.2019.112104_bib0185 article-title: A multifactorial approach to understanding fall risk in older people publication-title: J. Am. Geriatr. Soc. doi: 10.1111/j.1532-5415.2010.03017.x – volume: 105 start-page: 12569 issue: 34 year: 2008 ident: 10.1016/j.bbr.2019.112104_bib0095 article-title: A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0800005105 – volume: 319 start-page: 1701 issue: 26 year: 1988 ident: 10.1016/j.bbr.2019.112104_bib0015 article-title: Risk factors for falls among elderly persons living in the community publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198812293192604 – volume: 347 start-page: 1761 issue: 22 year: 2002 ident: 10.1016/j.bbr.2019.112104_bib0040 article-title: Abnormality of gait as a predictor of non-Alzheimer’s dementia publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa020441 – volume: 53 start-page: 695 issue: 4 year: 2005 ident: 10.1016/j.bbr.2019.112104_bib0180 article-title: The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment publication-title: J. Am. Geriatr. Soc. doi: 10.1111/j.1532-5415.2005.53221.x – volume: 18 start-page: 227 issue: 2 year: 2006 ident: 10.1016/j.bbr.2019.112104_bib0110 article-title: Age-related changes in brain activity across the adult lifespan publication-title: J. Cogn. Neurosci. doi: 10.1162/jocn.2006.18.2.227 – volume: 261 start-page: 2663 issue: 18 year: 1989 ident: 10.1016/j.bbr.2019.112104_bib0195 article-title: Risk factors for recurrent nonsyncopal falls. A prospective study publication-title: JAMA doi: 10.1001/jama.1989.03420180087036 – year: 1995 ident: 10.1016/j.bbr.2019.112104_bib0210 – volume: 3 start-page: 201 issue: 3 year: 2002 ident: 10.1016/j.bbr.2019.112104_bib0090 article-title: Control of goal-directed and stimulus-driven attention in the brain publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn755 – volume: 74 start-page: 936 issue: 5 year: 2012 ident: 10.1016/j.bbr.2019.112104_bib0100 article-title: Differential recruitment of the sensorimotor putamen and frontoparietal cortex during motor chunking in humans publication-title: Neuron doi: 10.1016/j.neuron.2012.03.038 – volume: 31 start-page: 772 issue: 5 year: 2010 ident: 10.1016/j.bbr.2019.112104_bib0135 article-title: Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer’s disease publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2008.06.015 – volume: 36 start-page: 8 issue: 1 year: 2012 ident: 10.1016/j.bbr.2019.112104_bib0070 article-title: Evidence of altered corticomotor system connectivity in early-stage Alzheimer’s disease publication-title: J. Neurol. Phys. Ther. doi: 10.1097/NPT.0b013e3182462ea6 – volume: 100 start-page: 14504 issue: 24 year: 2003 ident: 10.1016/j.bbr.2019.112104_bib0115 article-title: Functional deactivations: change with age and dementia of the Alzheimer type publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.2235925100 – volume: 35 start-page: 5 issue: 1 year: 2006 ident: 10.1016/j.bbr.2019.112104_bib0190 article-title: Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials publication-title: Age Ageing doi: 10.1093/ageing/afi218 – volume: 67 start-page: 980 issue: 8 year: 2010 ident: 10.1016/j.bbr.2019.112104_bib0035 article-title: The trajectory of gait speed preceding mild cognitive impairment publication-title: Arch. Neurol. doi: 10.1001/archneurol.2010.159 – volume: 83 start-page: 718 issue: 8 year: 2014 ident: 10.1016/j.bbr.2019.112104_bib0160 article-title: Motoric cognitive risk syndrome: multicountry prevalence and dementia risk publication-title: Neurology doi: 10.1212/WNL.0000000000000717 – volume: 68 start-page: 647 issue: 3 year: 1981 ident: 10.1016/j.bbr.2019.112104_bib0225 article-title: Normalizing transformations of some statistics in multivariate analysis publication-title: Biometrika doi: 10.1093/biomet/68.3.647 – volume: 2 year: 2010 ident: 10.1016/j.bbr.2019.112104_bib0075 article-title: Plasticity of brain networks in a randomized intervention trial of exercise training in older adults publication-title: Front. Aging Neurosci. – volume: 110 start-page: 146 year: 2018 ident: 10.1016/j.bbr.2019.112104_bib0165 article-title: Combined effects of mild cognitive impairment and slow gait on risk of dementia publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2018.06.002 – volume: 14 start-page: 1246 issue: 11 year: 2004 ident: 10.1016/j.bbr.2019.112104_bib0105 article-title: Fine modulation in network activation during motor execution and motor imagery publication-title: Cereb. Cortex doi: 10.1093/cercor/bhh086 |
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| SubjectTerms | Aberrant functional connectivity Falls Mild cognitive impairment Postural sway |
| Title | Head over heels but I forget why: Disruptive functional connectivity in older adult fallers with mild cognitive impairment |
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