Hepatitis B virus: predominance of genotype D in primitive tribes of the Andaman and Nicobar islands, India (1989-1999)

To understand the possible origin of hepatitis B virus (HBV), three of the four hyperendemic, primitive accessible tribes of the Andaman and Nicobar islands, India, were investigated. The Nicobarese tribe was investigated in 1989 and 1999. The S gene from 65 HBV isolates was amplified by PCR and seq...

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Veröffentlicht in:Journal of general virology Jg. 84; H. Pt 7; S. 1915
Hauptverfasser: Arankalle, V A, Murhekar, K M, Gandhe, S S, Murhekar, M V, Ramdasi, A Y, Padbidri, V S, Sehgal, S C
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 01.07.2003
Schlagworte:
African Continental Ancestry Group
Amino Acid Sequence
Asian Continental Ancestry Group
Continental Population Groups
Female
Genotype
Hepatitis B - epidemiology
Hepatitis B - virology
Hepatitis B Surface Antigens - blood
Hepatitis B virus - classification
Hepatitis B virus - genetics
Humans
India - epidemiology
Male
Molecular Sequence Data
Oceanic Ancestry Group
Phylogeny
Prevalence
Sequence Analysis, DNA
Serotyping
India
ISSN:0022-1317
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Abstract To understand the possible origin of hepatitis B virus (HBV), three of the four hyperendemic, primitive accessible tribes of the Andaman and Nicobar islands, India, were investigated. The Nicobarese tribe was investigated in 1989 and 1999. The S gene from 65 HBV isolates was amplified by PCR and sequenced. Genotyping and serotyping were carried out on the basis of phylogenetic and amino acid analyses of S gene. All 20 Nicobarese-89 isolates, nine Onges-99 isolates and the single Andamanese-99 HBV isolate were classified as genotype D. Of the Nicobarese-99 isolates, 32 (91.4 %) and three (8.6 %) were genotypes D and A, respectively. Per cent nucleotide identity between the S sequences representing different tribes varied from 98.06 to 98.59 % and varied from mainland isolates by 1.6-2.0 %. Although southeast Asian origin is postulated for the Nicobarese tribe, the presence of different genotypes suggests introduction of HBV after migration to these islands, probably from mainland India, 200 years back, when these islands became inhabited as a part of penal settlement during the British regimen.
AbstractList To understand the possible origin of hepatitis B virus (HBV), three of the four hyperendemic, primitive accessible tribes of the Andaman and Nicobar islands, India, were investigated. The Nicobarese tribe was investigated in 1989 and 1999. The S gene from 65 HBV isolates was amplified by PCR and sequenced. Genotyping and serotyping were carried out on the basis of phylogenetic and amino acid analyses of S gene. All 20 Nicobarese-89 isolates, nine Onges-99 isolates and the single Andamanese-99 HBV isolate were classified as genotype D. Of the Nicobarese-99 isolates, 32 (91.4 %) and three (8.6 %) were genotypes D and A, respectively. Per cent nucleotide identity between the S sequences representing different tribes varied from 98.06 to 98.59 % and varied from mainland isolates by 1.6-2.0 %. Although southeast Asian origin is postulated for the Nicobarese tribe, the presence of different genotypes suggests introduction of HBV after migration to these islands, probably from mainland India, 200 years back, when these islands became inhabited as a part of penal settlement during the British regimen.To understand the possible origin of hepatitis B virus (HBV), three of the four hyperendemic, primitive accessible tribes of the Andaman and Nicobar islands, India, were investigated. The Nicobarese tribe was investigated in 1989 and 1999. The S gene from 65 HBV isolates was amplified by PCR and sequenced. Genotyping and serotyping were carried out on the basis of phylogenetic and amino acid analyses of S gene. All 20 Nicobarese-89 isolates, nine Onges-99 isolates and the single Andamanese-99 HBV isolate were classified as genotype D. Of the Nicobarese-99 isolates, 32 (91.4 %) and three (8.6 %) were genotypes D and A, respectively. Per cent nucleotide identity between the S sequences representing different tribes varied from 98.06 to 98.59 % and varied from mainland isolates by 1.6-2.0 %. Although southeast Asian origin is postulated for the Nicobarese tribe, the presence of different genotypes suggests introduction of HBV after migration to these islands, probably from mainland India, 200 years back, when these islands became inhabited as a part of penal settlement during the British regimen.
To understand the possible origin of hepatitis B virus (HBV), three of the four hyperendemic, primitive accessible tribes of the Andaman and Nicobar islands, India, were investigated. The Nicobarese tribe was investigated in 1989 and 1999. The S gene from 65 HBV isolates was amplified by PCR and sequenced. Genotyping and serotyping were carried out on the basis of phylogenetic and amino acid analyses of S gene. All 20 Nicobarese-89 isolates, nine Onges-99 isolates and the single Andamanese-99 HBV isolate were classified as genotype D. Of the Nicobarese-99 isolates, 32 (91.4 %) and three (8.6 %) were genotypes D and A, respectively. Per cent nucleotide identity between the S sequences representing different tribes varied from 98.06 to 98.59 % and varied from mainland isolates by 1.6-2.0 %. Although southeast Asian origin is postulated for the Nicobarese tribe, the presence of different genotypes suggests introduction of HBV after migration to these islands, probably from mainland India, 200 years back, when these islands became inhabited as a part of penal settlement during the British regimen.
Author Arankalle, V A
Ramdasi, A Y
Gandhe, S S
Murhekar, K M
Padbidri, V S
Murhekar, M V
Sehgal, S C
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  givenname: K M
  surname: Murhekar
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  organization: National Institute of Virology, 20-A Dr Ambedkar Road, 411001 Pune, India
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  surname: Murhekar
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  surname: Ramdasi
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  givenname: S C
  surname: Sehgal
  fullname: Sehgal, S C
  organization: Regional Medical Research Center, Port Blair, Andaman and Nicobar islands, India
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Snippet To understand the possible origin of hepatitis B virus (HBV), three of the four hyperendemic, primitive accessible tribes of the Andaman and Nicobar islands,...
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SubjectTerms African Continental Ancestry Group
Amino Acid Sequence
Asian Continental Ancestry Group
Continental Population Groups
Female
Genotype
Hepatitis B - epidemiology
Hepatitis B - virology
Hepatitis B Surface Antigens - blood
Hepatitis B virus - classification
Hepatitis B virus - genetics
Humans
India - epidemiology
Male
Molecular Sequence Data
Oceanic Ancestry Group
Phylogeny
Prevalence
Sequence Analysis, DNA
Serotyping
Title Hepatitis B virus: predominance of genotype D in primitive tribes of the Andaman and Nicobar islands, India (1989-1999)
URI https://www.ncbi.nlm.nih.gov/pubmed/12810887
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