Connective Tissue and Fibroblast Senescence in Skin Aging

There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately remove senescent (SEN) fibroblasts from tissu...

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Published in:Journal of investigative dermatology Vol. 141; no. 4S; p. 985
Main Authors: Wlaschek, Meinhard, Maity, Pallab, Makrantonaki, Evgenia, Scharffetter-Kochanek, Karin
Format: Journal Article
Language:English
Published: United States 01.04.2021
ISSN:1523-1747, 1523-1747
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Abstract There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately remove senescent (SEN) fibroblasts from tissues. SEN fibroblasts by the release of the proinflammatory, tissue degrading senescent-associated secretory phenotype factors and vesicles with distinct cargo impact on their endogenous niche and spread senescence and skin aging. In this review, we will further discuss less noticed facets, including the plasticity of distinct dermal fibroblast phenotypes, the underestimated impact of the extracellular matrix itself, and the depletion of fibroblast subsets on skin homeostasis and aging.
AbstractList There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately remove senescent (SEN) fibroblasts from tissues. SEN fibroblasts by the release of the proinflammatory, tissue degrading senescent-associated secretory phenotype factors and vesicles with distinct cargo impact on their endogenous niche and spread senescence and skin aging. In this review, we will further discuss less noticed facets, including the plasticity of distinct dermal fibroblast phenotypes, the underestimated impact of the extracellular matrix itself, and the depletion of fibroblast subsets on skin homeostasis and aging.
There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately remove senescent (SEN) fibroblasts from tissues. SEN fibroblasts by the release of the proinflammatory, tissue degrading senescent-associated secretory phenotype factors and vesicles with distinct cargo impact on their endogenous niche and spread senescence and skin aging. In this review, we will further discuss less noticed facets, including the plasticity of distinct dermal fibroblast phenotypes, the underestimated impact of the extracellular matrix itself, and the depletion of fibroblast subsets on skin homeostasis and aging.There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately remove senescent (SEN) fibroblasts from tissues. SEN fibroblasts by the release of the proinflammatory, tissue degrading senescent-associated secretory phenotype factors and vesicles with distinct cargo impact on their endogenous niche and spread senescence and skin aging. In this review, we will further discuss less noticed facets, including the plasticity of distinct dermal fibroblast phenotypes, the underestimated impact of the extracellular matrix itself, and the depletion of fibroblast subsets on skin homeostasis and aging.
Author Scharffetter-Kochanek, Karin
Makrantonaki, Evgenia
Wlaschek, Meinhard
Maity, Pallab
Author_xml – sequence: 1
  givenname: Meinhard
  surname: Wlaschek
  fullname: Wlaschek, Meinhard
  organization: Department of Dermatology and Allergic Diseases, Ulm University, Ulm, Germany
– sequence: 2
  givenname: Pallab
  surname: Maity
  fullname: Maity, Pallab
  organization: Department of Dermatology and Allergic Diseases, Ulm University, Ulm, Germany
– sequence: 3
  givenname: Evgenia
  surname: Makrantonaki
  fullname: Makrantonaki, Evgenia
  organization: Department of Dermatology and Allergic Diseases, Ulm University, Ulm, Germany; Dermatology Center Wildeshausen, Wildeshausen, Germany
– sequence: 4
  givenname: Karin
  surname: Scharffetter-Kochanek
  fullname: Scharffetter-Kochanek, Karin
  email: karin.scharffetter-kochanek@uniklinik-ulm.de
  organization: Department of Dermatology and Allergic Diseases, Ulm University, Ulm, Germany. Electronic address: karin.scharffetter-kochanek@uniklinik-ulm.de
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33563466$$D View this record in MEDLINE/PubMed
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