Strategies for improving expression of recombinant human chorionic gonadotropin in Chinese Hamster Ovary (CHO) cells

Optimizations of the gene expression cassette combined with the selection of an appropriate signal peptide are important factors that must be considered to enhance heterologous protein expression in Chinese Hamster Ovary (CHO) cells. In this study, we investigated the effectiveness of different sign...

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Bibliographic Details
Published in:	Protein expression and purification Vol. 225; p. 106596
Main Authors:	Boukari, Iheb, Rourou, Samia, Bouzazi, Dorsaf, Essafi-Benkhadir, Khadija, Kallel, Héla
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2025
Subjects:	Animals CHO Cells Chorionic Gonadotropin - biosynthesis Chorionic Gonadotropin - genetics Chorionic Gonadotropin - pharmacology Cricetinae Cricetulus Gene Expression Human chorionic gonadotropin Humans Protein Sorting Signals - genetics Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Signal peptide Stable pool. bioprocess optimization Transfection Signal peptide Stable pool. bioprocess optimization CHO cells Human chorionic gonadotropin
ISSN:	1046-5928, 1096-0279, 1096-0279
Online Access:	Get full text
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