Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421

ACE2 (angiotensin converting enzyme 2) plays a critical role in the local tissue RAS (renin-angiotensin system) by hydrolysing the potent hypertensive and mitogenic peptide AngII (angiotensin II). Changes in the levels of ACE2 have been observed in a number of pathologies, including cardiovascular d...

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Veröffentlicht in:	Clinical science (1979) Jg. 127; H. 4; S. 243
Hauptverfasser:	Lambert, Daniel W, Lambert, Louise A, Clarke, Nicola E, Hooper, Nigel M, Porter, Karen E, Turner, Anthony J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.08.2014
Schlagworte:	Angiotensin II - genetics Angiotensin II - metabolism Angiotensin-Converting Enzyme 2 Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Down-Regulation - genetics Gene Expression Regulation - genetics Humans MicroRNAs - genetics MicroRNAs - metabolism Peptidyl-Dipeptidase A - metabolism Renin-Angiotensin System - genetics Transcription, Genetic
ISSN:	1470-8736, 1470-8736
Online-Zugang:	Weitere Angaben
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