Single-chain bolalipids PC-C24-PC and PC-C32-PC: impact on skin permeation and penetration of caffeine ex vivo, structural organization of the stratum corneum and corneocyte morphology

•synthetic symmetric single-chain bolalipids (SSCBs) do not promote the skin penetration of caffeine ex vivo using the porcine ear model.•both quantitative confocal Raman spectroscopy ex vivo and classic diffusion cell studies support this observation.•SSCBs can be tracked after penetration into por...

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Vydané v:	European journal of pharmaceutical sciences Ročník 212; s. 107205
Hlavní autori:	Abdelrahman, Namarig, Schmolz, Jakob, Schwarzinger, Jacqueline, Drescher, Simon, Riethmüller, Christoph, Dailey, Lea Ann, Klang, Victoria
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 01.09.2025
Predmet:	Administration, Cutaneous Animals ATR-FTIR Bolalipids Caffeine Caffeine - administration & dosage Caffeine - chemistry Caffeine - pharmacokinetics Confocal Raman spectroscopy Epidermis - metabolism Penetration, permeation Permeability Skin - drug effects Skin - metabolism Skin Absorption - drug effects Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman Swine Penetration, permeation Bolalipids Confocal Raman spectroscopy ATR-FTIR Caffeine
ISSN:	0928-0987, 1879-0720, 1879-0720
On-line prístup:	Získať plný text
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