The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis

Colorectal cancer (CRC) is a common tumor worldwide. CRC is influenced by several types of miRNAs and long non-coding RNAs. This study aims to evaluate the correlation of lncRNA ZFAS1/ miR200b/ ZEB1 protein with presence of CRC. Quantitative real-time polymerase chain reaction was used to measure se...

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Vydáno v:Pathology, research and practice Ročník 247; s. 154567
Hlavní autoři: Salman, Islam T., Abulsoud, Ahmed I., Abo-Elmatty, Dina M., Fawzy, Amal, Mesbah, Noha M., Saleh, Samy M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany Elsevier GmbH 01.07.2023
Témata:
Colorectal cancer
LncRNA
MiR200b
ZEB1
ZFASI
CRP
lncRNAs
MiR200b
RT
ZFAS1
Colorectal cancer
LncRNA
ALT
SD
miRNA
cDNA
CEA
AST
qRT-PCR
ROC
IQR
EMT
KLF2
r
PC
ZEB1
ZNFX1
CRC
CA 19–9
Sn
MET
Sp
ZFASI
ISSN:0344-0338, 1618-0631, 1618-0631
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Shrnutí:Colorectal cancer (CRC) is a common tumor worldwide. CRC is influenced by several types of miRNAs and long non-coding RNAs. This study aims to evaluate the correlation of lncRNA ZFAS1/ miR200b/ ZEB1 protein with presence of CRC. Quantitative real-time polymerase chain reaction was used to measure serum expression of lncRNA ZFAS1 and microRNA-200b in 60 CRC patients and 28 control subjects. ZEB1 protein in serum was measured by ELISA. Lnc ZFAS1 and ZEB1 were up-regulated in CRC patients in compare to control subjects while miR-200b was down-regulated. There was a linear correlation between ZAFS1 expression and miR-200b and ZEB1 in CRC. ZFAS1 is a key player of CRC progression and could be a potential therapeutic target by sponging miR-200b. In-addition the association between ZFAS1, miR-200b and ZEB1 highlights their potential value as a novel diagnostic biomarker in human CRC. [Display omitted]
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0344-0338
1618-0631
1618-0631
DOI:10.1016/j.prp.2023.154567