Bone marrow mesenchymal stem cells regulate TGF‐β to adjust neuroinflammation in postoperative central inflammatory mice

Background Postoperative cognitive dysfunction (POCD) is one of the common postoperative complications, which is more common in aged patients. POCD mainly manifests as cognitive function changes after surgery, such as memory decline and inattention. In some severe cases, patients may suffer from per...

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Bibliographic Details
Published in:	Journal of cellular biochemistry Vol. 121; no. 1; pp. 371 - 384
Main Authors:	Sun, Zhen‐Zhen, Li, Yun‐Feng, Xv, Zhi‐Peng, Zhang, You‐Zhi, Mi, Wei‐Dong
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.01.2020
Subjects:	Animal models Animals Apoptosis Behavior, Animal BMSCs Bone marrow Bone Marrow Cells - metabolism Cell Differentiation - drug effects Cell Survival Cognitive ability Cognitive Dysfunction - metabolism Disease Models, Animal Enzyme-Linked Immunosorbent Assay Growth factors Inflammation Inflammation - metabolism Inhibition (psychology) Lipopolysaccharides Lipopolysaccharides - metabolism Male Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchyme Mice Mice, Inbred C57BL neuroinflammation Neurons - metabolism postoperative central inflammatory Postoperative Period Protein expression Proteins Signal Transduction Signaling Smad2 protein Smad2 Protein - metabolism Social behavior Stem cell transplantation Stem cells Surgery TGF‐β Transforming Growth Factor beta - metabolism Transforming growth factor-b TGF-β postoperative central inflammatory neuroinflammation BMSCs
ISSN:	0730-2312, 1097-4644, 1097-4644
Online Access:	Get full text
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