Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity
Objectives Dissolving microneedle patches have been extensively studied in the field of cosmetics comparison with topical cosmetics focusing on the delivery of active ingredients. Nevertheless, the skin improvement effect of hyaluronic acid, which is mainly used as a backbone material for dissolving...
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| Veröffentlicht in: | International journal of cosmetic science Jg. 42; H. 3; S. 302 - 309 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
Wiley Subscription Services, Inc
01.06.2020
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| Schlagworte: | |
| ISSN: | 0142-5463, 1468-2494, 1468-2494 |
| Online-Zugang: | Volltext |
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| Abstract | Objectives
Dissolving microneedle patches have been extensively studied in the field of cosmetics comparison with topical cosmetics focusing on the delivery of active ingredients. Nevertheless, the skin improvement effect of hyaluronic acid, which is mainly used as a backbone material for dissolving microneedle, was not analyzed. In this study, adenosine encapsulated high and low molecular weight hyaluronic acid dissolving microneedle patch (Ad‐HMN and Ad‐LMN) were evaluated with respect to skin wrinkling, dermal density, elasticity, and safety in a clinical test on the crow’s feet area.
Methods
Clinical efficacy and safety tests were performed for 12 weeks on twenty three female subjects with wrinkles around their eyes. The Ad‐HMN and Ad‐LMN patch were applied once every 3 days, in the evening, for 8 weeks to the designated crow’s feet area. Skin wrinkling, dermal density, and elasticity were measured by using PRIMOS® premium, Dermascan®C, Cutometer® MPA580, and Corneometer® CM 825, respectively.
Results
Both Ad‐HMN and Ad‐LMN groups showed statistically significant efficacy for almost all parameters. The Ad‐HMN patch had better effect on the mean depth of biggest wrinkles, maximum depth of biggest wrinkles, dermal density, and skin elasticity than the Ad‐LMN patch. No adverse effects were observed in either group during the test period.
Conclusion
In the clinical efficacy test of four skin‐improvement parameters, the Ad‐HMN patch showed the better effect than the Ad‐LMN patch with the similar adenosine dose.
(a) Skin scanner images in crow’s feet region following consecutive application of the test material in the Ad‐HMN group (adenosine‐encapsulated high molecular weight HA DMNs) and the Ad‐LMN group (adenosine‐encapsulated low molecular weight HA DMNs) for 12 weeks. (b) Changes in the dermal density in crow’s feet region following consecutive application of the test material in the Ad‐HMN group and the Ad‐LMN group for 12 weeks. (c) Changes in the skin elasticity in crow’s feet region following consecutive application of the test material in the Ad‐HMN group and the Ad‐LMN group. Measurements were recorded before use, after 4 and 8 weeks of use and 2 weeks and 4 weeks after the use of the product was stopped. Both groups showed significant improvement in dermal density; these improvements were more enhanced in the Ad‐HMN group (n = 23, mean ± SEM; *P < 0.05, ***P < 0.001 compared with the values †P < 0.05 A vs. B groups based on before treatment).
Résumé
Objectifs
Les patches à micro‐aiguilles dissolvantes ont fait l’objet d’études approfondies dans le domaine de la cosmétique en comparaison avec la cosmétique topique axée sur la diffusion de principes actifs. Cependant, l’effet améliorant de l’acide hyaluronique sur la peau, principalement utilisée comme matière de base pour la dissolution des micro‐aiguilles, n’a pas été analysé. Dans la présente étude, les patchs à micro‐éguilles dissolvant l’acide hyaluronique à poids moléculaire élevé et faible, encapsulé dans l’adénosine (Ad‐HMN et Ad‐LMN) ont été analysés par rapport à la formation des rides, la densité cutanée, l’élasticité et la sécurité d’emploi lors d’un test clinique sur la zone de pattes d’oie.
Méthodes
Des tests d’efficacité et de sécurité cliniques ont été réalisés pendant 12 semaines sur 23 sujets féminins ayant des rides autour des yeux. Les patchs Ad‐HMN et Ad‐LMN ont été appliqués une fois tous les trois jours, le soir, pendant huit semaines, dans la zone à pattes d’oie désignée. La formation de rides, la densité cutanée et l’élasticité ont été mesurées à l’aide de PRIMOS® premium, Dermascan® C, Cutometer® MPA580 et Corneometer® CM825, respectivement.
Résultats
Les deux groupes Ad‐HMN et Ad‐LMN ont présenté une efficacité statistiquement significative pour la quasi‐totalité des paramètres. Le patch Ad‐HMN a eu un meilleur effet sur la profondeur moyenne des rides les plus importantes, la profondeur maximale des rides les plus importantes, la densité cutanée et l’élasticité de la peau par rapport au patch Ad‐LMN. Aucun effet indésirable n’a été observé dans aucun des groupes pendant la période d’essai.
Conclusion
Lors du test d’efficacité clinique des quatre paramètres d’amélioration de la peau, le patch Ad‐HMN a eu un meilleur effet que le patch Ad‐LMN avec la dose d’adénosine similaire. |
|---|---|
| AbstractList | Dissolving microneedle patches have been extensively studied in the field of cosmetics comparison with topical cosmetics focusing on the delivery of active ingredients. Nevertheless, the skin improvement effect of hyaluronic acid, which is mainly used as a backbone material for dissolving microneedle, was not analyzed. In this study, adenosine encapsulated high and low molecular weight hyaluronic acid dissolving microneedle patch (Ad-HMN and Ad-LMN) were evaluated with respect to skin wrinkling, dermal density, elasticity, and safety in a clinical test on the crow's feet area.
Clinical efficacy and safety tests were performed for 12 weeks on twenty three female subjects with wrinkles around their eyes. The Ad-HMN and Ad-LMN patch were applied once every 3 days, in the evening, for 8 weeks to the designated crow's feet area. Skin wrinkling, dermal density, and elasticity were measured by using PRIMOS
premium, Dermascan
C, Cutometer
MPA580, and Corneometer
CM 825, respectively.
Both Ad-HMN and Ad-LMN groups showed statistically significant efficacy for almost all parameters. The Ad-HMN patch had better effect on the mean depth of biggest wrinkles, maximum depth of biggest wrinkles, dermal density, and skin elasticity than the Ad-LMN patch. No adverse effects were observed in either group during the test period.
In the clinical efficacy test of four skin-improvement parameters, the Ad-HMN patch showed the better effect than the Ad-LMN patch with the similar adenosine dose. Dissolving microneedle patches have been extensively studied in the field of cosmetics comparison with topical cosmetics focusing on the delivery of active ingredients. Nevertheless, the skin improvement effect of hyaluronic acid, which is mainly used as a backbone material for dissolving microneedle, was not analyzed. In this study, adenosine encapsulated high and low molecular weight hyaluronic acid dissolving microneedle patch (Ad-HMN and Ad-LMN) were evaluated with respect to skin wrinkling, dermal density, elasticity, and safety in a clinical test on the crow's feet area.OBJECTIVESDissolving microneedle patches have been extensively studied in the field of cosmetics comparison with topical cosmetics focusing on the delivery of active ingredients. Nevertheless, the skin improvement effect of hyaluronic acid, which is mainly used as a backbone material for dissolving microneedle, was not analyzed. In this study, adenosine encapsulated high and low molecular weight hyaluronic acid dissolving microneedle patch (Ad-HMN and Ad-LMN) were evaluated with respect to skin wrinkling, dermal density, elasticity, and safety in a clinical test on the crow's feet area.Clinical efficacy and safety tests were performed for 12 weeks on twenty three female subjects with wrinkles around their eyes. The Ad-HMN and Ad-LMN patch were applied once every 3 days, in the evening, for 8 weeks to the designated crow's feet area. Skin wrinkling, dermal density, and elasticity were measured by using PRIMOS® premium, Dermascan® C, Cutometer® MPA580, and Corneometer® CM 825, respectively.METHODSClinical efficacy and safety tests were performed for 12 weeks on twenty three female subjects with wrinkles around their eyes. The Ad-HMN and Ad-LMN patch were applied once every 3 days, in the evening, for 8 weeks to the designated crow's feet area. Skin wrinkling, dermal density, and elasticity were measured by using PRIMOS® premium, Dermascan® C, Cutometer® MPA580, and Corneometer® CM 825, respectively.Both Ad-HMN and Ad-LMN groups showed statistically significant efficacy for almost all parameters. The Ad-HMN patch had better effect on the mean depth of biggest wrinkles, maximum depth of biggest wrinkles, dermal density, and skin elasticity than the Ad-LMN patch. No adverse effects were observed in either group during the test period.RESULTSBoth Ad-HMN and Ad-LMN groups showed statistically significant efficacy for almost all parameters. The Ad-HMN patch had better effect on the mean depth of biggest wrinkles, maximum depth of biggest wrinkles, dermal density, and skin elasticity than the Ad-LMN patch. No adverse effects were observed in either group during the test period.In the clinical efficacy test of four skin-improvement parameters, the Ad-HMN patch showed the better effect than the Ad-LMN patch with the similar adenosine dose.CONCLUSIONIn the clinical efficacy test of four skin-improvement parameters, the Ad-HMN patch showed the better effect than the Ad-LMN patch with the similar adenosine dose. ObjectivesDissolving microneedle patches have been extensively studied in the field of cosmetics comparison with topical cosmetics focusing on the delivery of active ingredients. Nevertheless, the skin improvement effect of hyaluronic acid, which is mainly used as a backbone material for dissolving microneedle, was not analyzed. In this study, adenosine encapsulated high and low molecular weight hyaluronic acid dissolving microneedle patch (Ad‐HMN and Ad‐LMN) were evaluated with respect to skin wrinkling, dermal density, elasticity, and safety in a clinical test on the crow’s feet area.MethodsClinical efficacy and safety tests were performed for 12 weeks on twenty three female subjects with wrinkles around their eyes. The Ad‐HMN and Ad‐LMN patch were applied once every 3 days, in the evening, for 8 weeks to the designated crow’s feet area. Skin wrinkling, dermal density, and elasticity were measured by using PRIMOS® premium, Dermascan®C, Cutometer® MPA580, and Corneometer® CM 825, respectively.ResultsBoth Ad‐HMN and Ad‐LMN groups showed statistically significant efficacy for almost all parameters. The Ad‐HMN patch had better effect on the mean depth of biggest wrinkles, maximum depth of biggest wrinkles, dermal density, and skin elasticity than the Ad‐LMN patch. No adverse effects were observed in either group during the test period.ConclusionIn the clinical efficacy test of four skin‐improvement parameters, the Ad‐HMN patch showed the better effect than the Ad‐LMN patch with the similar adenosine dose. Objectives Dissolving microneedle patches have been extensively studied in the field of cosmetics comparison with topical cosmetics focusing on the delivery of active ingredients. Nevertheless, the skin improvement effect of hyaluronic acid, which is mainly used as a backbone material for dissolving microneedle, was not analyzed. In this study, adenosine encapsulated high and low molecular weight hyaluronic acid dissolving microneedle patch (Ad‐HMN and Ad‐LMN) were evaluated with respect to skin wrinkling, dermal density, elasticity, and safety in a clinical test on the crow’s feet area. Methods Clinical efficacy and safety tests were performed for 12 weeks on twenty three female subjects with wrinkles around their eyes. The Ad‐HMN and Ad‐LMN patch were applied once every 3 days, in the evening, for 8 weeks to the designated crow’s feet area. Skin wrinkling, dermal density, and elasticity were measured by using PRIMOS® premium, Dermascan®C, Cutometer® MPA580, and Corneometer® CM 825, respectively. Results Both Ad‐HMN and Ad‐LMN groups showed statistically significant efficacy for almost all parameters. The Ad‐HMN patch had better effect on the mean depth of biggest wrinkles, maximum depth of biggest wrinkles, dermal density, and skin elasticity than the Ad‐LMN patch. No adverse effects were observed in either group during the test period. Conclusion In the clinical efficacy test of four skin‐improvement parameters, the Ad‐HMN patch showed the better effect than the Ad‐LMN patch with the similar adenosine dose. (a) Skin scanner images in crow’s feet region following consecutive application of the test material in the Ad‐HMN group (adenosine‐encapsulated high molecular weight HA DMNs) and the Ad‐LMN group (adenosine‐encapsulated low molecular weight HA DMNs) for 12 weeks. (b) Changes in the dermal density in crow’s feet region following consecutive application of the test material in the Ad‐HMN group and the Ad‐LMN group for 12 weeks. (c) Changes in the skin elasticity in crow’s feet region following consecutive application of the test material in the Ad‐HMN group and the Ad‐LMN group. Measurements were recorded before use, after 4 and 8 weeks of use and 2 weeks and 4 weeks after the use of the product was stopped. Both groups showed significant improvement in dermal density; these improvements were more enhanced in the Ad‐HMN group (n = 23, mean ± SEM; *P < 0.05, ***P < 0.001 compared with the values †P < 0.05 A vs. B groups based on before treatment). Résumé Objectifs Les patches à micro‐aiguilles dissolvantes ont fait l’objet d’études approfondies dans le domaine de la cosmétique en comparaison avec la cosmétique topique axée sur la diffusion de principes actifs. Cependant, l’effet améliorant de l’acide hyaluronique sur la peau, principalement utilisée comme matière de base pour la dissolution des micro‐aiguilles, n’a pas été analysé. Dans la présente étude, les patchs à micro‐éguilles dissolvant l’acide hyaluronique à poids moléculaire élevé et faible, encapsulé dans l’adénosine (Ad‐HMN et Ad‐LMN) ont été analysés par rapport à la formation des rides, la densité cutanée, l’élasticité et la sécurité d’emploi lors d’un test clinique sur la zone de pattes d’oie. Méthodes Des tests d’efficacité et de sécurité cliniques ont été réalisés pendant 12 semaines sur 23 sujets féminins ayant des rides autour des yeux. Les patchs Ad‐HMN et Ad‐LMN ont été appliqués une fois tous les trois jours, le soir, pendant huit semaines, dans la zone à pattes d’oie désignée. La formation de rides, la densité cutanée et l’élasticité ont été mesurées à l’aide de PRIMOS® premium, Dermascan® C, Cutometer® MPA580 et Corneometer® CM825, respectivement. Résultats Les deux groupes Ad‐HMN et Ad‐LMN ont présenté une efficacité statistiquement significative pour la quasi‐totalité des paramètres. Le patch Ad‐HMN a eu un meilleur effet sur la profondeur moyenne des rides les plus importantes, la profondeur maximale des rides les plus importantes, la densité cutanée et l’élasticité de la peau par rapport au patch Ad‐LMN. Aucun effet indésirable n’a été observé dans aucun des groupes pendant la période d’essai. Conclusion Lors du test d’efficacité clinique des quatre paramètres d’amélioration de la peau, le patch Ad‐HMN a eu un meilleur effet que le patch Ad‐LMN avec la dose d’adénosine similaire. |
| Author | Yang, H. Kim, S. Kang, G. Jung, H. Jang, M. Baek, S. |
| Author_xml | – sequence: 1 givenname: M. surname: Jang fullname: Jang, M. organization: Juvic Inc – sequence: 2 givenname: S. surname: Baek fullname: Baek, S. organization: Juvic Inc – sequence: 3 givenname: G. surname: Kang fullname: Kang, G. organization: Juvic Inc – sequence: 4 givenname: H. surname: Yang fullname: Yang, H. organization: Juvic Inc – sequence: 5 givenname: S. surname: Kim fullname: Kim, S. organization: Yonsei University – sequence: 6 givenname: H. orcidid: 0000-0002-5716-5426 surname: Jung fullname: Jung, H. email: hijung@yonsei.ac.kr organization: Juvic Inc |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32421218$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/smll.201001091 10.7317/pk.2015.39.6.976 10.1002/adma.200701205 10.1016/j.jconrel.2012.05.030 10.1111/ics.12299 10.1021/acs.molpharmaceut.7b00111 10.1002/adma.201506025 10.1021/bm101446k 10.1002/adhm.201700326 10.1073/pnas.1505405112 10.1016/j.cps.2004.12.002 10.1016/j.ijpharm.2006.05.024 10.1111/ics.12115 10.1111/ics.12453 10.1038/nm.2182 10.1001/archderm.143.2.155 10.1186/s40824-016-0073-3 10.1111/jocd.12178 10.1016/S0168-3659(00)00300-X 10.1007/s11095-011-0419-4 10.3109/00016488709102834 |
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| Copyright | 2020 Society of Cosmetic Scientists and the Société Française de Cosmétologie 2020 Society of Cosmetic Scientists and the Société Française de Cosmétologie. Copyright © 2020 Society of Cosmetic Scientists and the Société Française de Cosmétologie |
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| Keywords | delivery vectorization wrinkle improvement skin physiology surfactants penetration dissolving microneedle polymers structure |
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| References | 2012; 161 2017; 6 2010; 16 2015; 39 2000; 69 2017; 14 1987; 104 2007; 143 2015; 112 2016; 20 2014; 36 2005; 32 2011; 12 2018; 40 2008; 20 2011; 28 2014; 52 2016; 28 2016; 38 2016; 15 2011; 7 2006; 322 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_23_1 e_1_2_7_11_1 e_1_2_7_22_1 e_1_2_7_21_1 e_1_2_7_20_1 Park J. (e_1_2_7_10_1) 2014; 52 |
| References_xml | – volume: 36 start-page: 207 year: 2014 end-page: 212 article-title: Novel cosmetic patches for wrinkle improvement: retinyl retinoate‐and ascorbic acid‐loaded dissolving microneedles publication-title: Int. J. Cosmetic Sci. – volume: 15 start-page: 16 year: 2016 end-page: 23 article-title: 4‐n‐butylresorcinol dissolving microneedle patch for skin depigmentation: a randomized, double‐blind, placebo‐controlled trial publication-title: J. Cosmetic Dermatol. – volume: 20 start-page: 933 year: 2008 end-page: 938 article-title: Minimally invasive protein delivery with rapidly dissolving polymer microneedles publication-title: Adv. Mater. – volume: 6 start-page: 1700326 year: 2017 article-title: Centrifugal lithography: self‐shaping of polymer microstructures encapsulating biopharmaceutics by centrifuging polymer drops publication-title: Adv. Healthcare Mater. – volume: 112 start-page: 8260 year: 2015 end-page: 8265 article-title: Microneedle‐array patches loaded with hypoxia‐sensitive vesicles provide fast glucose‐responsive insulin delivery publication-title: Proc. Natl. Acad. Sci. – volume: 20 start-page: 24 year: 2016 article-title: Effect of molecular weight of hyaluronic acid (HA) on viscoelasticity and particle texturing feel of HA dermal biphasic fillers publication-title: Biomater. Res. – volume: 32 start-page: 151 year: 2005 end-page: 162 article-title: Injectable skin fillers publication-title: Clin. Plastic Surgery – volume: 161 start-page: 933 year: 2012 end-page: 941 article-title: The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin publication-title: J. Controlled Release. – volume: 38 start-page: 375 year: 2016 end-page: 381 article-title: Evaluation of the anti‐wrinkle effect of an ascorbic acid‐loaded dissolving microneedle patch via a double‐blind, placebo‐controlled clinical study publication-title: Int. J. Cosmetic Sci. – volume: 28 start-page: 1919 year: 2011 end-page: 1930 article-title: Laser‐engineered dissolving microneedle arrays for transdermal macromolecular drug delivery publication-title: Pharmaceut. Res. – volume: 7 start-page: 531 year: 2011 end-page: 539 article-title: Dissolving microneedle patch for transdermal delivery of human growth hormone publication-title: Small – volume: 12 start-page: 824 year: 2011 end-page: 830 article-title: Diels− Alder click cross‐linked hyaluronic acid hydrogels for tissue engineering publication-title: Biomacromol – volume: 16 start-page: 915 year: 2010 article-title: Dissolving polymer microneedle patches for influenza vaccination publication-title: Nat. Med. – volume: 52 start-page: 597 year: 2014 end-page: 607 article-title: Efficacy of biodegradable microneedle patches on periorbital wrinkles publication-title: Korean J. Dermatol. – volume: 69 start-page: 169 year: 2000 end-page: 184 article-title: Cross‐linked hyaluronic acid hydrogel films: new biomaterials for drug delivery publication-title: J. Controll. Release – volume: 40 start-page: 199 year: 2018 end-page: 206 article-title: Adenosine‐loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration publication-title: Int. J. Cosmetic Sci. – volume: 28 start-page: 3115 year: 2016 end-page: 3121 article-title: Microneedles integrated with pancreatic cells and synthetic glucose‐signal amplifiers for smart insulin delivery publication-title: Adv. Materials. – volume: 143 start-page: 155 year: 2007 end-page: 163 article-title: In vivo stimulation of de novo collagen production caused by cross‐linked hyaluronic acid dermal filler injections in photodamaged human skin publication-title: Arch. Dermatol. – volume: 322 start-page: 44 year: 2006 end-page: 51 article-title: Sustained release formulation of erythropoietin using hyaluronic acid hydrogels crosslinked by Michael addition publication-title: Int. J. Pharmaceut. – volume: 14 start-page: 2024 year: 2017 end-page: 2031 article-title: Enhanced transdermal delivery by combined application of dissolving microneedle patch on serum‐treated skin publication-title: Mol. Pharmaceut. – volume: 39 start-page: 976 year: 2015 end-page: 980 article-title: Influence of molecular weight on swelling and elastic modulus of hyaluronic acid dermal fillers publication-title: Polymer (Korea) – volume: 104 start-page: 25 issue: sup442 year: 1987 end-page: 30 article-title: Rheology of hyaluronate publication-title: Acta Otolaryngol. – ident: e_1_2_7_6_1 doi: 10.1002/smll.201001091 – volume: 52 start-page: 597 year: 2014 ident: e_1_2_7_10_1 article-title: Efficacy of biodegradable microneedle patches on periorbital wrinkles publication-title: Korean J. Dermatol. – ident: e_1_2_7_23_1 doi: 10.7317/pk.2015.39.6.976 – ident: e_1_2_7_2_1 doi: 10.1002/adma.200701205 – ident: e_1_2_7_5_1 doi: 10.1016/j.jconrel.2012.05.030 – ident: e_1_2_7_9_1 doi: 10.1111/ics.12299 – ident: e_1_2_7_11_1 doi: 10.1021/acs.molpharmaceut.7b00111 – ident: e_1_2_7_17_1 doi: 10.1002/adma.201506025 – ident: e_1_2_7_13_1 doi: 10.1021/bm101446k – ident: e_1_2_7_18_1 doi: 10.1002/adhm.201700326 – ident: e_1_2_7_16_1 doi: 10.1073/pnas.1505405112 – ident: e_1_2_7_21_1 doi: 10.1016/j.cps.2004.12.002 – ident: e_1_2_7_14_1 doi: 10.1016/j.ijpharm.2006.05.024 – ident: e_1_2_7_7_1 doi: 10.1111/ics.12115 – ident: e_1_2_7_19_1 doi: 10.1111/ics.12453 – ident: e_1_2_7_3_1 doi: 10.1038/nm.2182 – ident: e_1_2_7_20_1 doi: 10.1001/archderm.143.2.155 – ident: e_1_2_7_22_1 doi: 10.1186/s40824-016-0073-3 – ident: e_1_2_7_8_1 doi: 10.1111/jocd.12178 – ident: e_1_2_7_12_1 doi: 10.1016/S0168-3659(00)00300-X – ident: e_1_2_7_4_1 doi: 10.1007/s11095-011-0419-4 – ident: e_1_2_7_15_1 doi: 10.3109/00016488709102834 |
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| Title | Dissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticity |
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