Association of vitamin D in patients with periodontitis: A cross‐sectional study

Background and Objective Vitamin D has been considered to possess anti‐inflammatory and antimicrobial activity, which may be a link for the known interaction of periodontitis (CP) and coronary heart disease (CHD). This study investigated the association between serum vitamin D levels and periodontit...

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Vydáno v:Journal of periodontal research Ročník 55; číslo 5; s. 602 - 612
Hlavní autoři: Isola, Gaetano, Alibrandi, Angela, Rapisarda, Ernesto, Matarese, Giovanni, Williams, Ray C., Leonardi, Rosalia
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Wiley Subscription Services, Inc 01.10.2020
Témata:
Antimicrobial activity
C-Reactive Protein - analysis
Cardiovascular disease
Chronic Periodontitis - blood
Chronic Periodontitis - complications
Coronary artery disease
coronary disease
Coronary Disease - complications
Cross-Sectional Studies
Gum disease
Heart diseases
Humans
Inflammation
periodontal disease
Periodontitis
Periodontitis - blood
Periodontitis - complications
Serum levels
Vitamin D
Vitamin D - blood
cardiovascular disease
coronary disease
vitamin D
cross-sectional studies
periodontal disease
ISSN:0022-3484, 1600-0765, 1600-0765
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Shrnutí:Background and Objective Vitamin D has been considered to possess anti‐inflammatory and antimicrobial activity, which may be a link for the known interaction of periodontitis (CP) and coronary heart disease (CHD). This study investigated the association between serum vitamin D levels and periodontitis in patients with CP and with CHD. Furthermore, the objective was to determine whether periodontitis and CHD had an impact on serum vitamin D levels. Material and Methods Using a cross‐sectional design, a total of 46 patients with CP, 45 patients with CHD, 45 patients with both CP and CHD, and 43 healthy patients were enrolled in the present study. Results Patients in the CP (17.4 ± 5.2 ng/mL) and in the CP + CHD (16.5 ± 5.6 ng/mL) group presented a significantly lower mean serum level of 25(OH)vitamin D compared to patients in the CHD (24.6 ± 3.7 ng/mL) and healthy control groups (29.9 ± 5.4 ng/mL) (P < .001). 25(OH)vitamin D levels were positively correlated with the number of teeth and negatively with C‐reactive protein (CRP) and all periodontal parameters (P < .001). In all patients, there was a proportional increase of 25(OH)vitamin D levels with a progressive increase in number of teeth (P‐trend <.001) while there were a proportional decrease in 25(OH)vitamin D levels with a progressive increase in clinical attachment level (CAL, P‐trend = .001), probing depth (PD, P‐trend = .006), and bleeding sites (BOP, P‐trend <.001) levels. Conclusion Patients with CP and CP + CHD presented significantly lower serum levels of vitamin D compared to CHD and healthy controls. Moreover, the presence of CP negatively influenced serum vitamin D levels.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-3484
1600-0765
1600-0765
DOI:10.1111/jre.12746