Influence of Slco2b1‐knockout and SLCO2B1‐humanization on coproporphyrin I and III levels in rats

Background and Purpose Coproporphyrin (CP) I and III are byproducts of haem synthesis currently investigated as biomarkers for drug–drug interactions involving hepatic organic anion transporting polypeptide (OATP) 1B transporters. Another hepatically expressed OATP‐member is OATP2B1. The aim of this...

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Veröffentlicht in:	British journal of pharmacology Jg. 181; H. 1; S. 36 - 53
Hauptverfasser:	Kinzi, Jonny, Hussner, Janine, Schäfer, Anima M., Treyer, Andrea, Seibert, Isabell, Tillmann, Annika, Mueller, Vanessa, Gherardi, Clarisse, Vonwyl, Celina, Hamburger, Matthias, Meyer zu Schwabedissen, Henriette E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Blackwell Publishing Ltd 01.01.2024
Schlagworte:	Animal models Animals coproporphyrin Coproporphyrins - metabolism Drug interaction drug transporter Female humanized Humans Immunohistochemistry in vivo knockout Liver Liver - metabolism Membrane Transport Proteins - metabolism Multidrug resistance OATP2B1 Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Organic anion transporting polypeptide rat Rats Serum levels Statistical analysis knockout rat in vivo drug transporter humanized OATP2B1 coproporphyrin
ISSN:	0007-1188, 1476-5381, 1476-5381
Online-Zugang:	Volltext
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