Study of IL4‐590C/T and IL6‐174G/C Gene Polymorphisms in Type 2 Diabetic Patients With Chronic Kidney Disease in North Indian Population
ABSTRACT To explore the associations between potential functional promoter polymorphisms in pro‐inflammatory and anti‐inflammatory (IL‐4(‐590C/T) and IL‐6(‐174G/C) cytokine genes, and kidney dysfunction in North Indian type 2 diabetic subjects with chronic kidney disease. A total of 150 subjects age...
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| Vydané v: | Journal of cellular biochemistry Ročník 118; číslo 7; s. 1803 - 1809 |
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United States
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01.07.2017
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| Abstract | ABSTRACT
To explore the associations between potential functional promoter polymorphisms in pro‐inflammatory and anti‐inflammatory (IL‐4(‐590C/T) and IL‐6(‐174G/C) cytokine genes, and kidney dysfunction in North Indian type 2 diabetic subjects with chronic kidney disease. A total of 150 subjects aged 25–75 year were included in this study. The glomerular filtration rate (GFR) and serum creatinine were estimated. PCR was performed to analyse genotype distribution in IL‐4 (‐590T/C) and IL‐6 (‐174G/C) among healthy, type 2 diabetic patients with or without CKD. The genotype distributions were determined by Hardy–Weinberg equilibrium. CKD patients showed lower GFR (59.36 ± 1.33 ml/min/1.73 m2) and higher serum creatinine (1.93 ± 0.99% mg) level in comparison to diabetic patients without CKD and healthy subjects. Genotypic distribution of the different genotypes among the study groups in IL‐4 gene was genotype CC = 30, TC = 12, and TT = 8 in CKD patients. In type 2 diabetic patients without CKD, genotype distribution was CC = 38, TC = 10, and TT = 2. In healthy subjects, distribution of genotype was CC = 35, TC = 14, and TT = 1. The distribution of different genotype among the study groups for IL‐6 gene was GG = 27, GC = 20, and CC = 3 in healthy subjects; GG = 28, GC = 19, and CC = 3 in diabetic patients without CKD and GG = 38, GC = 11, and CC = 1 in diabetic patients with CKD. There was no significant difference in the distribution of genotype frequencies between healthy subjects and diabetic patients without CKD but a significant difference was found in diabetic patients with CKD. The functional promoter polymorphisms IL4‐590C/T and IL6‐174G/C, which affect the IL‐4 and IL‐6 levels in north Indian subjects, were associated with kidney dysfunction and CKD. J. Cell. Biochem. 118: 1803–1809, 2017. © 2016 Wiley Periodicals, Inc.
The associations between common potential functional promoter polymorphisms in pro‐inflammatory and anti‐inflammatory (IL‐4(‐590C/T) and IL‐6(‐174G/C) cytokine genes and kidney dysfunction in north Indian type 2 diabetic patients with chronic kidney disease. |
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| AbstractList | To explore the associations between potential functional promoter polymorphisms in pro-inflammatory and anti-inflammatory (IL-4(-590C/T) and IL-6(-174G/C) cytokine genes, and kidney dysfunction in North Indian type 2 diabetic subjects with chronic kidney disease. A total of 150 subjects aged 25-75 year were included in this study. The glomerular filtration rate (GFR) and serum creatinine were estimated. PCR was performed to analyse genotype distribution in IL-4 (-590T/C) and IL-6 (-174G/C) among healthy, type 2 diabetic patients with or without CKD. The genotype distributions were determined by Hardy-Weinberg equilibrium. CKD patients showed lower GFR (59.36 ± 1.33 ml/min/1.73 m2 ) and higher serum creatinine (1.93 ± 0.99% mg) level in comparison to diabetic patients without CKD and healthy subjects. Genotypic distribution of the different genotypes among the study groups in IL-4 gene was genotype CC = 30, TC = 12, and TT = 8 in CKD patients. In type 2 diabetic patients without CKD, genotype distribution was CC = 38, TC = 10, and TT = 2. In healthy subjects, distribution of genotype was CC = 35, TC = 14, and TT = 1. The distribution of different genotype among the study groups for IL-6 gene was GG = 27, GC = 20, and CC = 3 in healthy subjects; GG = 28, GC = 19, and CC = 3 in diabetic patients without CKD and GG = 38, GC = 11, and CC = 1 in diabetic patients with CKD. There was no significant difference in the distribution of genotype frequencies between healthy subjects and diabetic patients without CKD but a significant difference was found in diabetic patients with CKD. The functional promoter polymorphisms IL4-590C/T and IL6-174G/C, which affect the IL-4 and IL-6 levels in north Indian subjects, were associated with kidney dysfunction and CKD. J. Cell. Biochem. 118: 1803-1809, 2017. © 2016 Wiley Periodicals, Inc.To explore the associations between potential functional promoter polymorphisms in pro-inflammatory and anti-inflammatory (IL-4(-590C/T) and IL-6(-174G/C) cytokine genes, and kidney dysfunction in North Indian type 2 diabetic subjects with chronic kidney disease. A total of 150 subjects aged 25-75 year were included in this study. The glomerular filtration rate (GFR) and serum creatinine were estimated. PCR was performed to analyse genotype distribution in IL-4 (-590T/C) and IL-6 (-174G/C) among healthy, type 2 diabetic patients with or without CKD. The genotype distributions were determined by Hardy-Weinberg equilibrium. CKD patients showed lower GFR (59.36 ± 1.33 ml/min/1.73 m2 ) and higher serum creatinine (1.93 ± 0.99% mg) level in comparison to diabetic patients without CKD and healthy subjects. Genotypic distribution of the different genotypes among the study groups in IL-4 gene was genotype CC = 30, TC = 12, and TT = 8 in CKD patients. In type 2 diabetic patients without CKD, genotype distribution was CC = 38, TC = 10, and TT = 2. In healthy subjects, distribution of genotype was CC = 35, TC = 14, and TT = 1. The distribution of different genotype among the study groups for IL-6 gene was GG = 27, GC = 20, and CC = 3 in healthy subjects; GG = 28, GC = 19, and CC = 3 in diabetic patients without CKD and GG = 38, GC = 11, and CC = 1 in diabetic patients with CKD. There was no significant difference in the distribution of genotype frequencies between healthy subjects and diabetic patients without CKD but a significant difference was found in diabetic patients with CKD. The functional promoter polymorphisms IL4-590C/T and IL6-174G/C, which affect the IL-4 and IL-6 levels in north Indian subjects, were associated with kidney dysfunction and CKD. J. Cell. Biochem. 118: 1803-1809, 2017. © 2016 Wiley Periodicals, Inc. To explore the associations between potential functional promoter polymorphisms in pro-inflammatory and anti-inflammatory (IL-4(-590C/T) and IL-6(-174G/C) cytokine genes, and kidney dysfunction in North Indian type 2 diabetic subjects with chronic kidney disease. A total of 150 subjects aged 25-75 year were included in this study. The glomerular filtration rate (GFR) and serum creatinine were estimated. PCR was performed to analyse genotype distribution in IL-4 (-590T/C) and IL-6 (-174G/C) among healthy, type 2 diabetic patients with or without CKD. The genotype distributions were determined by Hardy-Weinberg equilibrium. CKD patients showed lower GFR (59.36±1.33ml/min/1.73m2) and higher serum creatinine (1.93±0.99% mg) level in comparison to diabetic patients without CKD and healthy subjects. Genotypic distribution of the different genotypes among the study groups in IL-4 gene was genotype CC=30, TC=12, and TT=8 in CKD patients. In type 2 diabetic patients without CKD, genotype distribution was CC=38, TC=10, and TT=2. In healthy subjects, distribution of genotype was CC=35, TC=14, and TT=1. The distribution of different genotype among the study groups for IL-6 gene was GG=27, GC=20, and CC=3 in healthy subjects; GG=28, GC=19, and CC=3 in diabetic patients without CKD and GG=38, GC=11, and CC=1 in diabetic patients with CKD. There was no significant difference in the distribution of genotype frequencies between healthy subjects and diabetic patients without CKD but a significant difference was found in diabetic patients with CKD. The functional promoter polymorphisms IL4-590C/T and IL6-174G/C, which affect the IL-4 and IL-6 levels in north Indian subjects, were associated with kidney dysfunction and CKD. J. Cell. Biochem. 118: 1803-1809, 2017. © 2016 Wiley Periodicals, Inc. To explore the associations between potential functional promoter polymorphisms in pro-inflammatory and anti-inflammatory (IL-4(-590C/T) and IL-6(-174G/C) cytokine genes, and kidney dysfunction in North Indian type 2 diabetic subjects with chronic kidney disease. A total of 150 subjects aged 25-75 year were included in this study. The glomerular filtration rate (GFR) and serum creatinine were estimated. PCR was performed to analyse genotype distribution in IL-4 (-590T/C) and IL-6 (-174G/C) among healthy, type 2 diabetic patients with or without CKD. The genotype distributions were determined by Hardy-Weinberg equilibrium. CKD patients showed lower GFR (59.36 ± 1.33 ml/min/1.73 m ) and higher serum creatinine (1.93 ± 0.99% mg) level in comparison to diabetic patients without CKD and healthy subjects. Genotypic distribution of the different genotypes among the study groups in IL-4 gene was genotype CC = 30, TC = 12, and TT = 8 in CKD patients. In type 2 diabetic patients without CKD, genotype distribution was CC = 38, TC = 10, and TT = 2. In healthy subjects, distribution of genotype was CC = 35, TC = 14, and TT = 1. The distribution of different genotype among the study groups for IL-6 gene was GG = 27, GC = 20, and CC = 3 in healthy subjects; GG = 28, GC = 19, and CC = 3 in diabetic patients without CKD and GG = 38, GC = 11, and CC = 1 in diabetic patients with CKD. There was no significant difference in the distribution of genotype frequencies between healthy subjects and diabetic patients without CKD but a significant difference was found in diabetic patients with CKD. The functional promoter polymorphisms IL4-590C/T and IL6-174G/C, which affect the IL-4 and IL-6 levels in north Indian subjects, were associated with kidney dysfunction and CKD. J. Cell. Biochem. 118: 1803-1809, 2017. © 2016 Wiley Periodicals, Inc. ABSTRACT To explore the associations between potential functional promoter polymorphisms in pro‐inflammatory and anti‐inflammatory (IL‐4(‐590C/T) and IL‐6(‐174G/C) cytokine genes, and kidney dysfunction in North Indian type 2 diabetic subjects with chronic kidney disease. A total of 150 subjects aged 25–75 year were included in this study. The glomerular filtration rate (GFR) and serum creatinine were estimated. PCR was performed to analyse genotype distribution in IL‐4 (‐590T/C) and IL‐6 (‐174G/C) among healthy, type 2 diabetic patients with or without CKD. The genotype distributions were determined by Hardy–Weinberg equilibrium. CKD patients showed lower GFR (59.36 ± 1.33 ml/min/1.73 m2) and higher serum creatinine (1.93 ± 0.99% mg) level in comparison to diabetic patients without CKD and healthy subjects. Genotypic distribution of the different genotypes among the study groups in IL‐4 gene was genotype CC = 30, TC = 12, and TT = 8 in CKD patients. In type 2 diabetic patients without CKD, genotype distribution was CC = 38, TC = 10, and TT = 2. In healthy subjects, distribution of genotype was CC = 35, TC = 14, and TT = 1. The distribution of different genotype among the study groups for IL‐6 gene was GG = 27, GC = 20, and CC = 3 in healthy subjects; GG = 28, GC = 19, and CC = 3 in diabetic patients without CKD and GG = 38, GC = 11, and CC = 1 in diabetic patients with CKD. There was no significant difference in the distribution of genotype frequencies between healthy subjects and diabetic patients without CKD but a significant difference was found in diabetic patients with CKD. The functional promoter polymorphisms IL4‐590C/T and IL6‐174G/C, which affect the IL‐4 and IL‐6 levels in north Indian subjects, were associated with kidney dysfunction and CKD. J. Cell. Biochem. 118: 1803–1809, 2017. © 2016 Wiley Periodicals, Inc. The associations between common potential functional promoter polymorphisms in pro‐inflammatory and anti‐inflammatory (IL‐4(‐590C/T) and IL‐6(‐174G/C) cytokine genes and kidney dysfunction in north Indian type 2 diabetic patients with chronic kidney disease. |
| Author | Alam, Khursheed Ahmad, Arif Neelofar, Km Ahmad, Jamal |
| Author_xml | – sequence: 1 givenname: Km surname: Neelofar fullname: Neelofar, Km organization: Aligarh Muslim University – sequence: 2 givenname: Jamal orcidid: 0000-0001-8161-807X surname: Ahmad fullname: Ahmad, Jamal email: neloferbiotech@gmail.com organization: Aligarh Muslim University – sequence: 3 givenname: Arif surname: Ahmad fullname: Ahmad, Arif organization: Maulana Azad National Urdu University – sequence: 4 givenname: Khursheed surname: Alam fullname: Alam, Khursheed organization: Aligarh Muslim University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27996163$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1371_journal_pone_0217042 crossref_primary_10_1007_s00125_019_4859_4 crossref_primary_10_3390_pathophysiology32020014 crossref_primary_10_1007_s11596_019_2027_1 crossref_primary_10_3390_jmp5030024 crossref_primary_10_1111_jcmm_16575 crossref_primary_10_3390_genes16091116 crossref_primary_10_1038_s41598_021_94075_x crossref_primary_10_1016_j_amjms_2019_07_011 crossref_primary_10_3892_etm_2018_7096 crossref_primary_10_1186_s13098_022_00851_8 crossref_primary_10_1002_jcb_25958 crossref_primary_10_1186_s12902_021_00738_1 |
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| Keywords | IL-4 TYPE 2 DIABETES CKD GENE POLYMORPHISM IL-6 |
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To explore the associations between potential functional promoter polymorphisms in pro‐inflammatory and anti‐inflammatory (IL‐4(‐590C/T) and... To explore the associations between potential functional promoter polymorphisms in pro-inflammatory and anti-inflammatory (IL-4(-590C/T) and IL-6(-174G/C)... |
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| SubjectTerms | Adult Aged Asian Continental Ancestry Group C gene CKD Creatinine Creatinine - blood Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 Electrophoresis, Agar Gel Female Gene Frequency - genetics GENE POLYMORPHISM Genes Genetic Association Studies Genetic Predisposition to Disease - genetics Genotype Genotypes Glomerular filtration rate Glomerular Filtration Rate - genetics Glomerular Filtration Rate - physiology Humans IL‐4 IL‐6 Inflammation Interleukin 4 Interleukin 6 Interleukin-4 - genetics Interleukin-6 - genetics Kidney diseases Kidney transplantation Kidneys Male Middle Aged Polymerase chain reaction Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - genetics TYPE 2 DIABETES |
| Title | Study of IL4‐590C/T and IL6‐174G/C Gene Polymorphisms in Type 2 Diabetic Patients With Chronic Kidney Disease in North Indian Population |
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