Global gene expression reveals an increase of HMGB1 and APEX1 proteins and their involvement in oxidative stress, apoptosis and inflammation pathways among beta‐thalassaemia intermedia and major phenotypes

Summary Beta‐thalassaemia (BT) is classified according to blood transfusion requirement as minor (BTMi), intermedia (BTI) and major (BTM). BTM is the most severe form, requiring regular transfusions while transfusion need is only occasional in BTI. Differential gene expression between patients has n...

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Vydáno v:	British journal of haematology Ročník 186; číslo 4; s. 608 - 619
Hlavní autoři:	Maia de Oliveira da Silva, João Pedro, Brugnerotto, Ana Flávia, S. Romanello, Karen, K. L. Teixeira, Karina, Lanaro, Carolina, S. Duarte, Adriana, G. L. Costa, Gustavo, da Silva Araújo, Aderson, C. Bezerra, Marcos André, de Farias Domingos, Igor, Pereira Martins, Diego A., Malavazi, Iran, F. Costa, Fernando, Cunha, Anderson F.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Blackwell Publishing Ltd 01.08.2019
Témata:	APEX1 Apoptosis Beta‐thalassaemia Blood diseases Blood transfusion Cell differentiation Erythroid cells Gene expression haemolytic anaemia Hematology HMGB1 HMGB1 protein Metabolic pathways Mutation Oxidative stress Phenotypes Reactive oxygen species Thalassemia Transcription haemolytic anaemia HMGB1 APEX1 Beta-thalassaemia oxidative stress
ISSN:	0007-1048, 1365-2141, 1365-2141
On-line přístup:	Získat plný text
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