Global gene expression reveals an increase of HMGB1 and APEX1 proteins and their involvement in oxidative stress, apoptosis and inflammation pathways among beta‐thalassaemia intermedia and major phenotypes

Summary Beta‐thalassaemia (BT) is classified according to blood transfusion requirement as minor (BTMi), intermedia (BTI) and major (BTM). BTM is the most severe form, requiring regular transfusions while transfusion need is only occasional in BTI. Differential gene expression between patients has n...

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Bibliographic Details
Published in:	British journal of haematology Vol. 186; no. 4; pp. 608 - 619
Main Authors:	Maia de Oliveira da Silva, João Pedro, Brugnerotto, Ana Flávia, S. Romanello, Karen, K. L. Teixeira, Karina, Lanaro, Carolina, S. Duarte, Adriana, G. L. Costa, Gustavo, da Silva Araújo, Aderson, C. Bezerra, Marcos André, de Farias Domingos, Igor, Pereira Martins, Diego A., Malavazi, Iran, F. Costa, Fernando, Cunha, Anderson F.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.08.2019
Subjects:	APEX1 Apoptosis Beta‐thalassaemia Blood diseases Blood transfusion Cell differentiation Erythroid cells Gene expression haemolytic anaemia Hematology HMGB1 HMGB1 protein Metabolic pathways Mutation Oxidative stress Phenotypes Reactive oxygen species Thalassemia Transcription haemolytic anaemia HMGB1 APEX1 Beta-thalassaemia oxidative stress
ISSN:	0007-1048, 1365-2141, 1365-2141
Online Access:	Get full text
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