Long noncoding RNA gastric cancer‐associated transcript 3 plays oncogenic roles in glioma through sponging miR‐3127‐5p

Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer‐associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular physiology Jg. 234; H. 6; S. 8825 - 8833
Hauptverfasser:	Pan, Bailin, Zhao, Ming, Xu, Longbiao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Wiley Subscription Services, Inc 01.06.2019
Schlagworte:	Adult Animals Apoptosis Bioinformatics Breast cancer Cancer Cell Movement Cell Proliferation Cells, Cultured Colorectal cancer Colorectal carcinoma ELAV-Like Protein 1 - genetics ELAV-Like Protein 1 - metabolism Female GACAT3 Gastric cancer Gene Expression Regulation, Neoplastic - physiology Gene Silencing Glioma Glioma - metabolism Glioma cells Humans invasion long noncoding RNA Lung cancer Male Mice Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged migration miRNA Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism proliferation Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Survival Target recognition Therapeutic applications Transcription Tumorigenesis long noncoding RNA migration glioma invasion proliferation GACAT3
ISSN:	0021-9541, 1097-4652, 1097-4652
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer‐associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is implicated in glioma has not been elucidated. Here, we found that GACAT3 level was aberrantly elevated in glioma tissues and cell lines. Higher GACAT3 expression predicted lower survival rate. Knockdown of GACAT3 suppressed the proliferation, colony formation, migration, and invasion but promoting apoptosis in glioma cells. Next, we determined that GACAT3 contributes to glioma progression through inhibiting microRNA (miR)‐3127‐5p. Subsequently, ELAVL1 was identified as a direct target of miR‐3127‐5p by bioinformatics analysis and luciferase reporter assay. Moreover, we confirmed that GACAT3 promoted ELAVL1 expression through sponging miR‐3127‐5p, leading to glioma progression. Taken together, our study elucidated that GACAT3/miR‐3127‐5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target. our study elucidated that GACAT3/miR‐3127‐5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target.
AbstractList	Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer‐associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is implicated in glioma has not been elucidated. Here, we found that GACAT3 level was aberrantly elevated in glioma tissues and cell lines. Higher GACAT3 expression predicted lower survival rate. Knockdown of GACAT3 suppressed the proliferation, colony formation, migration, and invasion but promoting apoptosis in glioma cells. Next, we determined that GACAT3 contributes to glioma progression through inhibiting microRNA (miR)‐3127‐5p. Subsequently, ELAVL1 was identified as a direct target of miR‐3127‐5p by bioinformatics analysis and luciferase reporter assay. Moreover, we confirmed that GACAT3 promoted ELAVL1 expression through sponging miR‐3127‐5p, leading to glioma progression. Taken together, our study elucidated that GACAT3/miR‐3127‐5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target. Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer-associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is implicated in glioma has not been elucidated. Here, we found that GACAT3 level was aberrantly elevated in glioma tissues and cell lines. Higher GACAT3 expression predicted lower survival rate. Knockdown of GACAT3 suppressed the proliferation, colony formation, migration, and invasion but promoting apoptosis in glioma cells. Next, we determined that GACAT3 contributes to glioma progression through inhibiting microRNA (miR)-3127-5p. Subsequently, ELAVL1 was identified as a direct target of miR-3127-5p by bioinformatics analysis and luciferase reporter assay. Moreover, we confirmed that GACAT3 promoted ELAVL1 expression through sponging miR-3127-5p, leading to glioma progression. Taken together, our study elucidated that GACAT3/miR-3127-5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target.Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer-associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is implicated in glioma has not been elucidated. Here, we found that GACAT3 level was aberrantly elevated in glioma tissues and cell lines. Higher GACAT3 expression predicted lower survival rate. Knockdown of GACAT3 suppressed the proliferation, colony formation, migration, and invasion but promoting apoptosis in glioma cells. Next, we determined that GACAT3 contributes to glioma progression through inhibiting microRNA (miR)-3127-5p. Subsequently, ELAVL1 was identified as a direct target of miR-3127-5p by bioinformatics analysis and luciferase reporter assay. Moreover, we confirmed that GACAT3 promoted ELAVL1 expression through sponging miR-3127-5p, leading to glioma progression. Taken together, our study elucidated that GACAT3/miR-3127-5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target. Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer‐associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is implicated in glioma has not been elucidated. Here, we found that GACAT3 level was aberrantly elevated in glioma tissues and cell lines. Higher GACAT3 expression predicted lower survival rate. Knockdown of GACAT3 suppressed the proliferation, colony formation, migration, and invasion but promoting apoptosis in glioma cells. Next, we determined that GACAT3 contributes to glioma progression through inhibiting microRNA (miR)‐3127‐5p. Subsequently, ELAVL1 was identified as a direct target of miR‐3127‐5p by bioinformatics analysis and luciferase reporter assay. Moreover, we confirmed that GACAT3 promoted ELAVL1 expression through sponging miR‐3127‐5p, leading to glioma progression. Taken together, our study elucidated that GACAT3/miR‐3127‐5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target. our study elucidated that GACAT3/miR‐3127‐5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target.
Author	Zhao, Ming Xu, Longbiao Pan, Bailin
Author_xml	– sequence: 1 givenname: Bailin orcidid: 0000-0001-6917-8606 surname: Pan fullname: Pan, Bailin email: bailinpan18@163.com organization: Zhuji People’s Hospital of Zhejiang Province, Zhuji Affiliated Hospital of Wenzhou Medical University – sequence: 2 givenname: Ming surname: Zhao fullname: Zhao, Ming organization: Zhuji People’s Hospital of Zhejiang Province, Zhuji Affiliated Hospital of Wenzhou Medical University – sequence: 3 givenname: Longbiao surname: Xu fullname: Xu, Longbiao organization: Zhuji People’s Hospital of Zhejiang Province, Zhuji Affiliated Hospital of Wenzhou Medical University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30317610$$D View this record in MEDLINE/PubMed
BookMark	eNp1kc1u1DAURi1URKeFBS-ALLGBRVr_JvGyGgEtGgGqYG05zk3qUWIHO1E1EgsegWfkSfAw000Fq2vJ5zu27neGTnzwgNBLSi4oIexya6cLVknBnqAVJaoqRCnZCVrlO1ooKegpOktpSwhRivNn6JQTTquSkhX6sQm-x9lnQ-vy6fbTFe5NmqOz2BpvIf7--cukFKwzM7R4jsYnG900Y46nwewS3md78DkQwwAJO4_7wYXR4PkuhqW_w2nKj-zto7vNOk5ZlYecnqOnnRkSvDjOc_Tt_buv6-ti8_nDzfpqU1guOSuEYaQWpi07bhkI4HXLJQPWdh3UQrBWqbYSQkhRl8oq0zWyaRjwVgFtJK_4OXpz8E4xfF8gzXp0ycIwGA9hSZpRRhiRNaUZff0I3YYl-vy7TNVc1WUtVaZeHamlGaHVU3SjiTv9sNcMXB4AG0NKETpt3WxmF3xeoBs0JXrfnM7N6b_N5cTbR4kH6b_Yo_3eDbD7P6g_rr8cEn8AV3GpzA
CitedBy_id	crossref_primary_10_1089_cbr_2019_3390 crossref_primary_10_1016_j_prp_2023_154688 crossref_primary_10_3390_cancers14143516 crossref_primary_10_3389_fonc_2019_01383 crossref_primary_10_3389_fcell_2022_785030 crossref_primary_10_1038_s41420_021_00551_8 crossref_primary_10_4014_jmb_2103_03001 crossref_primary_10_3389_fonc_2020_00780 crossref_primary_10_1186_s12935_021_02192_4 crossref_primary_10_1038_s41401_021_00767_5 crossref_primary_10_1002_jcla_23378 crossref_primary_10_1007_s43032_021_00802_0 crossref_primary_10_3389_fgene_2020_00180 crossref_primary_10_1155_2020_9180732 crossref_primary_10_1007_s10616_025_00749_z
Cites_doi	10.1371/journal.pone.0070372 10.1155/2017/7639084 10.1093/nar/gkq285 10.1038/nature03702 10.1038/nature05519 10.1007/BF00228580 10.3389/fgene.2012.00219 10.1016/j.cell.2013.06.009 10.1016/j.cellsig.2014.11.011 10.1038/ncpneuro0289 10.1007/s00401-016-1545-1 10.1016/j.prnil.2016.07.002 10.1038/ncomms13608 10.1186/s12943-018-0813-1 10.1038/nature13311 10.1101/gr.132159.111 10.1111/febs.12737 10.1007/s40273-014-0198-y 10.1016/j.gene.2018.08.081 10.1111/j.1365-2443.2011.01502.x 10.1007/s11060-011-0793-0 10.7554/eLife.01749 10.1002/cam4.775 10.1016/j.bbagrm.2015.06.015 10.4161/rna.24604 10.1073/pnas.0504367102 10.1073/pnas.97.12.6242 10.1007/978-3-540-31206-2_5 10.2147/OTT.S166132 10.1002/jcp.24549 10.3390/cancers7030843 10.1016/j.celrep.2012.06.003 10.1038/ni.3712 10.1517/17425247.4.2.175
ContentType	Journal Article
Copyright	2018 Wiley Periodicals, Inc. 2019 Wiley Periodicals, Inc.
Copyright_xml	– notice: 2018 Wiley Periodicals, Inc. – notice: 2019 Wiley Periodicals, Inc.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TK 7U7 8FD C1K FR3 K9. P64 RC3 7X8
DOI	10.1002/jcp.27542
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Genetics Abstracts Technology Research Database Toxicology Abstracts ProQuest Health & Medical Complete (Alumni) Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic
DatabaseTitleList	Genetics Abstracts MEDLINE - Academic MEDLINE CrossRef
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Anatomy & Physiology Biology
EISSN	1097-4652
EndPage	8833
ExternalDocumentID	30317610 10_1002_jcp_27542 JCP27542
Genre	article Journal Article
GroupedDBID	--- -DZ -~X .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 36B 3O- 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 85S 8UM 930 9M8 A03 AAESR AAEVG AAHHS AAHQN AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABDPE ABEFU ABEML ABIJN ABJNI ABPPZ ABPVW ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACNCT ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFWVQ AFZJQ AHBTC AHMBA AIAGR AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AUFTA AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BQCPF BROTX BRXPI BY8 CS3 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRSTM DU5 EBD EBS EJD EMB EMOBN F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA H.T H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ H~9 IH2 IX1 J0M JPC KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M56 MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MVM MXFUL MXSTM N04 N05 N9A NEJ NF~ NNB O66 O9- OHT OIG P2P P2W P2X P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO ROL RWI RWR RX1 RYL S10 SAMSI SUPJJ SV3 TN5 TWZ UB1 UPT V2E V8K VQP W8V W99 WBKPD WH7 WIB WIH WIK WJL WNSPC WOHZO WQJ WRC WXSBR WYB WYISQ X7M XG1 XJT XOL XPP XSW XV2 Y6R YQT YZZ ZGI ZXP ZZTAW ~IA ~WT AAMMB AAYXX ABUFD ADXHL AEFGJ AETEA AEYWJ AGHNM AGQPQ AGXDD AGYGG AIDQK AIDYY CITATION O8X CGR CUY CVF ECM EIF NPM 7TK 7U7 8FD C1K FR3 K9. P64 RC3 7X8
ID	FETCH-LOGICAL-c3532-4a2084ad6f3c2e4e38d352e2dffe8442d99d744454869c9afb5bb2e3d9e1b5373
IEDL.DBID	DRFUL
ISICitedReferencesCount	17
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000459314500099&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0021-9541 1097-4652
IngestDate	Sun Nov 23 09:34:05 EST 2025 Sat Nov 29 14:38:48 EST 2025 Thu Apr 03 07:09:43 EDT 2025 Sat Nov 29 02:48:59 EST 2025 Tue Nov 18 21:37:36 EST 2025 Wed Jan 22 17:10:30 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	6
Keywords	long noncoding RNA migration glioma invasion proliferation GACAT3
Language	English
License	2018 Wiley Periodicals, Inc.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c3532-4a2084ad6f3c2e4e38d352e2dffe8442d99d744454869c9afb5bb2e3d9e1b5373
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0001-6917-8606
PMID	30317610
PQID	2183986859
PQPubID	1006363
PageCount	9
ParticipantIDs	proquest_miscellaneous_2120205811 proquest_journals_2183986859 pubmed_primary_30317610 crossref_citationtrail_10_1002_jcp_27542 crossref_primary_10_1002_jcp_27542 wiley_primary_10_1002_jcp_27542_JCP27542
PublicationCentury	2000
PublicationDate	June 2019 2019-06-00 20190601
PublicationDateYYYYMMDD	2019-06-01
PublicationDate_xml	– month: 06 year: 2019 text: June 2019
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: Hoboken
PublicationTitle	Journal of cellular physiology
PublicationTitleAlternate	J Cell Physiol
PublicationYear	2019
Publisher	Wiley Subscription Services, Inc
Publisher_xml	– name: Wiley Subscription Services, Inc
References	e_1_2_7_1_10_1 e_1_2_7_1_33_1 e_1_2_7_1_11_1 e_1_2_7_1_32_1 e_1_2_7_1_12_1 e_1_2_7_1_35_1 e_1_2_7_1_13_1 e_1_2_7_1_30_1 e_1_2_7_1_31_1 e_1_2_7_1_5_1 e_1_2_7_1_29_1 e_1_2_7_1_6_1 e_1_2_7_1_7_1 e_1_2_7_1_8_1 e_1_2_7_1_25_1 e_1_2_7_1_2_1 e_1_2_7_1_26_1 e_1_2_7_1_3_1 e_1_2_7_1_27_1 e_1_2_7_1_4_1 e_1_2_7_1_21_1 e_1_2_7_1_22_1 e_1_2_7_1_23_1 Wang Y. (e_1_2_7_1_34_1) 2018; 22 e_1_2_7_1_24_1 e_1_2_7_1_9_1 e_1_2_7_1_20_1 e_1_2_7_1_18_1 e_1_2_7_1_19_1 Trojan L. A. (e_1_2_7_1_28_1) 2003; 48 e_1_2_7_1_14_1 e_1_2_7_1_37_1 e_1_2_7_1_15_1 e_1_2_7_1_36_1 e_1_2_7_1_16_1 e_1_2_7_1_17_1
References_xml	– ident: e_1_2_7_1_5_1 doi: 10.1371/journal.pone.0070372 – ident: e_1_2_7_1_2_1 doi: 10.1155/2017/7639084 – ident: e_1_2_7_1_31_1 doi: 10.1093/nar/gkq285 – ident: e_1_2_7_1_16_1 doi: 10.1038/nature03702 – ident: e_1_2_7_1_19_1 doi: 10.1038/nature05519 – ident: e_1_2_7_1_22_1 doi: 10.1007/BF00228580 – ident: e_1_2_7_1_27_1 doi: 10.3389/fgene.2012.00219 – ident: e_1_2_7_1_10_1 doi: 10.1016/j.cell.2013.06.009 – volume: 22 start-page: 5223 issue: 16 year: 2018 ident: e_1_2_7_1_34_1 article-title: Long non‐coding RNA AFAP1‐AS1 accelerates invasion and predicts poor prognosis of glioma publication-title: European Review for Medical and Pharmacological Sciences – ident: e_1_2_7_1_33_1 doi: 10.1016/j.cellsig.2014.11.011 – ident: e_1_2_7_1_25_1 doi: 10.1038/ncpneuro0289 – ident: e_1_2_7_1_15_1 doi: 10.1007/s00401-016-1545-1 – ident: e_1_2_7_1_20_1 doi: 10.1016/j.prnil.2016.07.002 – ident: e_1_2_7_1_37_1 doi: 10.1038/ncomms13608 – ident: e_1_2_7_1_7_1 doi: 10.1186/s12943-018-0813-1 – volume: 48 start-page: 18 year: 2003 ident: e_1_2_7_1_28_1 article-title: IGF‐I triple helix gene therapy of rat and human gliomas publication-title: Roczniki Akademii Medycznej W Bialymstoku – ident: e_1_2_7_1_29_1 doi: 10.1038/nature13311 – ident: e_1_2_7_1_6_1 doi: 10.1101/gr.132159.111 – ident: e_1_2_7_1_8_1 doi: 10.1111/febs.12737 – ident: e_1_2_7_1_21_1 doi: 10.1007/s40273-014-0198-y – ident: e_1_2_7_1_32_1 doi: 10.1016/j.gene.2018.08.081 – ident: e_1_2_7_1_30_1 doi: 10.1111/j.1365-2443.2011.01502.x – ident: e_1_2_7_1_4_1 doi: 10.1007/s11060-011-0793-0 – ident: e_1_2_7_1_24_1 doi: 10.7554/eLife.01749 – ident: e_1_2_7_1_26_1 doi: 10.1002/cam4.775 – ident: e_1_2_7_1_14_1 doi: 10.1016/j.bbagrm.2015.06.015 – ident: e_1_2_7_1_17_1 doi: 10.4161/rna.24604 – ident: e_1_2_7_1_9_1 doi: 10.1073/pnas.0504367102 – ident: e_1_2_7_1_11_1 doi: 10.1073/pnas.97.12.6242 – ident: e_1_2_7_1_23_1 doi: 10.1007/978-3-540-31206-2_5 – ident: e_1_2_7_1_35_1 doi: 10.2147/OTT.S166132 – ident: e_1_2_7_1_3_1 doi: 10.1002/jcp.24549 – ident: e_1_2_7_1_12_1 doi: 10.3390/cancers7030843 – ident: e_1_2_7_1_36_1 doi: 10.1016/j.celrep.2012.06.003 – ident: e_1_2_7_1_13_1 doi: 10.1038/ni.3712 – ident: e_1_2_7_1_18_1 doi: 10.1517/17425247.4.2.175
SSID	ssj0009933
Score	2.3907993
Snippet	Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer‐associated transcript 3 (GACAT3) is reported... Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer-associated transcript 3 (GACAT3) is reported...
SourceID	proquest pubmed crossref wiley
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	8825
SubjectTerms	Adult Animals Apoptosis Bioinformatics Breast cancer Cancer Cell Movement Cell Proliferation Cells, Cultured Colorectal cancer Colorectal carcinoma ELAV-Like Protein 1 - genetics ELAV-Like Protein 1 - metabolism Female GACAT3 Gastric cancer Gene Expression Regulation, Neoplastic - physiology Gene Silencing Glioma Glioma - metabolism Glioma cells Humans invasion long noncoding RNA Lung cancer Male Mice Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged migration miRNA Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism proliferation Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Survival Target recognition Therapeutic applications Transcription Tumorigenesis
Title	Long noncoding RNA gastric cancer‐associated transcript 3 plays oncogenic roles in glioma through sponging miR‐3127‐5p
URI	https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcp.27542 https://www.ncbi.nlm.nih.gov/pubmed/30317610 https://www.proquest.com/docview/2183986859 https://www.proquest.com/docview/2120205811
Volume	234
WOSCitedRecordID	wos000459314500099&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1097-4652 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0009933 issn: 0021-9541 databaseCode: DRFUL dateStart: 19960101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bi9NAFD7sdhV88bLrpbouo4j4EreZSzKDT2W1iCxlKS70LcxMJqXSJqXpCgUf_An-Rn-JZyZplkUFwacEcuaSOefMfDM5OR_AK6FkgdBeRGpQsIgznUTaCo0K0YVhRlJtB4FsIh2P5XSqLvbg3e5fmCY_RHfg5j0jzNfewbWpT6-Thn6xq7fU87fuwwFFuxU9OHg_GV2eX-fcbZnkQxSC4PEusdCAnnaFby5Hv2HMm5A1rDmje__V2_twt4WaZNjYxgPYc-UhHA1L3GYvt-Q1CcGf4VT9EG43nJTbI_h2XpUzUlalrfyyRibjIZlpz-5hifUmsv75_YdulepysvGLXZh6CCOrhd7WxJdFu8QCPnaxJvOSzBbzaqlJywpEfFyuZ0ciy_kEq2MxTfEiVg_hcvTh89nHqKVoiCwTjEZc04HkOk8KZqnjjskcEZ2jeVE4yTnNlcpTzjnuixJlFepfGEMdy5WLjWApewQ9fCP3BEicaixnkjQuKC94ajyrlsQaZWJZYUwf3uw0ldk2f7mn0VhkTeZlmuEYZ2GM-_CyE101STv-JHS8U3fW-m2dBcAoEylUH150j9Hj_GcUXbrqystQxNhCxnEfHjdm0rWCgCBOEZFiZ4M1_L357NPZRbh5-u-iz-AO4jXVRKodQ2-zvnLP4Zb9upnX6xPYT6fypHWCX_icC0Q
linkProvider	Wiley-Blackwell
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFD4aGwheuGxcCgMMQmgvYY0viS3xUg2qAaWaqk3aW2Q7TlXUJlXbIVXigZ_Ab-SXcOykmSZAQuIpkeJbfM7x-eycnA_glVCyQGgvItUtWMSZTiJthUaB6MIwI6m23UA2kQ6H8vxcnWzB282_MHV-iPbAzVtGWK-9gfsD6cPLrKFf7PwN9QSu12CHoxqhfu-8G_XPBpdJdxsq-RCGIHi8ySzUpYdt5av-6DeQeRWzBqfTv_N_w70LtxuwSXq1dtyDLVfuwl6vxI32bE1ekxD-Gc7Vd-FGzUq53oNvg6ock7IqbeUdGxkNe2SsPb-HJdYryeLn9x-6EavLycq7u7D4EEbmU71eEl8XNRMr-OjFJZmUZDydVDNNGl4g4iNzPT8SmU1G2ByLaYoXMb8PZ_33p0fHUUPSEFkmGI24pl3JdZ4UzFLHHZM5YjpH86JwknOaK5WnnHPcGSXKKtQAYQx1LFcuNoKl7AFs4xu5R0DiVGM9k6RxQXnBU-N5tSS2KBPLCmM6cLARVWabDOaeSGOa1bmXaYZznIU57sDLtui8Ttvxp0L7G3lnjeUuswAZZSKF6sCL9jHanP-QoktXXfgyFFG2kHHcgYe1nrS9ICSIU8SkONigDn_vPvt4dBJuHv970edw8_j08yAbfBh-egK3EL2pOm5tH7ZXiwv3FK7br6vJcvGssYVfn0UOTA
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bi9NAFD6sXRVfvOzqWl11FJF9idvMJZmAL2XX4qWUUlzYtzCZzJQubRLarlDwwZ_gb_SXeGaSZllUEHxKIHPLnHPmfDM5OR_Aa5FIi9BeBEnPsoAzFQVKC4UCUTZjmaRK9zzZRDwayfPzZLwD77b_wtT5IdoDN2cZfr12Bm6q3B5fZQ290NVb6ghcb8AudyQyHdg9nQzOhldJdxsqeR-GIHi4zSzUo8dt5ev-6DeQeR2zeqczuPd_w70PdxuwSfq1djyAHVPswX6_wI32YkPeEB_-6c_V9-BWzUq52Ydvw7KYkqIsdOkcG5mM-mSqHL-HJtopyfLn9x-qEavJydq5O7_4EEaqudqsiKuLmokVXPTiiswKMp3PyoUiDS8QcZG5jh-JLGYTbI6FNMaLqB7C2eD9l5MPQUPSEGgmGA24oj3JVR5ZpqnhhskcMZ2hubVGck7zJMljzjnujKJEJ6gBIsuoYXliwkywmD2CDr6ReQwkjBXWy6I4tJRbHmeOV0tiizLSzGZZF462okp1k8HcEWnM0zr3Mk1xjlM_x1141Rat6rQdfyp0uJV32ljuKvWQUUZSJF142T5Gm3MfUlRhyktXhiLKFjIMu3BQ60nbC0KCMEZMioP16vD37tNPJ2N_8-Tfi76A2-PTQTr8OPr8FO4geEvqsLVD6KyXl-YZ3NRf17PV8nljCr8AFqANxw
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long+noncoding+RNA+gastric+cancer%E2%80%90associated+transcript+3+plays+oncogenic+roles+in+glioma+through+sponging+miR%E2%80%903127%E2%80%905p&rft.jtitle=Journal+of+cellular+physiology&rft.au=Pan%2C+Bailin&rft.au=Zhao%2C+Ming&rft.au=Xu%2C+Longbiao&rft.date=2019-06-01&rft.pub=Wiley+Subscription+Services%2C+Inc&rft.issn=0021-9541&rft.eissn=1097-4652&rft.volume=234&rft.issue=6&rft.spage=8825&rft.epage=8833&rft_id=info:doi/10.1002%2Fjcp.27542&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9541&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9541&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9541&client=summon