L‐lactate production in engineered Saccharomyces cerevisiae using a multistage multiobjective automated design framework

The design of alternative biodegradable polymers has the potential of severely reducing the environmental impact, cost and production time currently associated with the petrochemical industry. In fact, growing demand for renewable feedstock has recently brought to the fore synthetic biology and meta...

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Vydáno v:	Biotechnology and bioengineering Ročník 120; číslo 7; s. 1929 - 1952
Hlavní autoři:	Amaradio, Matteo N., Jansen, Giorgio, Costanza, Jole, Patanè, Andrea, Branduardi, Paola, Porro, Danilo, Nicosia, Giuseppe
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Wiley Subscription Services, Inc 01.07.2023
Témata:	Anaerobic conditions Automation Biocatalysts Biodegradability Biodegradation Bioplastics Biotechnology Design Environmental impact Evolutionary algorithms Gene regulation gene regulation optimization Genetic engineering genetic manipulation optimization Lactic acid Lactic Acid - metabolism L‐lactate production medium optimization Metabolic engineering Metabolic Engineering - methods Metabolism Microorganisms Multiple objective analysis Optimization Organic acids Pareto optimality Petrochemicals Petrochemicals industry Polymers Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Sustainable production Yeast L-lactate production medium optimization Pareto optimality genetic manipulation optimization metabolic engineering gene regulation optimization
ISSN:	0006-3592, 1097-0290, 1097-0290
On-line přístup:	Získat plný text
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