L‐lactate production in engineered Saccharomyces cerevisiae using a multistage multiobjective automated design framework

The design of alternative biodegradable polymers has the potential of severely reducing the environmental impact, cost and production time currently associated with the petrochemical industry. In fact, growing demand for renewable feedstock has recently brought to the fore synthetic biology and meta...

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Bibliographic Details
Published in:	Biotechnology and bioengineering Vol. 120; no. 7; pp. 1929 - 1952
Main Authors:	Amaradio, Matteo N., Jansen, Giorgio, Costanza, Jole, Patanè, Andrea, Branduardi, Paola, Porro, Danilo, Nicosia, Giuseppe
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.07.2023
Subjects:	Anaerobic conditions Automation Biocatalysts Biodegradability Biodegradation Bioplastics Biotechnology Design Environmental impact Evolutionary algorithms Gene regulation gene regulation optimization Genetic engineering genetic manipulation optimization Lactic acid Lactic Acid - metabolism L‐lactate production medium optimization Metabolic engineering Metabolic Engineering - methods Metabolism Microorganisms Multiple objective analysis Optimization Organic acids Pareto optimality Petrochemicals Petrochemicals industry Polymers Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Sustainable production Yeast L-lactate production medium optimization Pareto optimality genetic manipulation optimization metabolic engineering gene regulation optimization
ISSN:	0006-3592, 1097-0290, 1097-0290
Online Access:	Get full text
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