Prevalence of Helicobacter pylori infection in China: A systematic review and meta‐analysis

Background and Aim Helicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically evaluated the longitudinal trends in H. pylori prevalence in China over the past decades. Methods We performed a systematic review of literature re...

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Vydáno v:Journal of gastroenterology and hepatology Ročník 37; číslo 3; s. 464 - 470
Hlavní autoři: Ren, Shuai, Cai, Pengpeng, Liu, Yaqian, Wang, Tianpei, Zhang, Yan, Li, Qian, Gu, Yuanliang, Wei, Liqin, Yan, Caiwang, Jin, Guangfu
Médium: Journal Article
Jazyk:angličtina
Vydáno: Australia Wiley Subscription Services, Inc 01.03.2022
Témata:
China
China - epidemiology
epidemiology
Gastric cancer
Helicobacter Infections - epidemiology
Helicobacter pylori
Humans
Infections
Meta-analysis
Prevalence
Systematic review
China
meta-analysis
epidemiology
prevalence
Helicobacter pylori
China
ISSN:0815-9319, 1440-1746, 1440-1746
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Abstract Background and Aim Helicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically evaluated the longitudinal trends in H. pylori prevalence in China over the past decades. Methods We performed a systematic review of literature reporting the prevalence of H. pylori infection in mainland China from 1990 to 2019 in the PubMed and China National Knowledge Infrastructure databases. We conducted a meta‐analysis of qualified studies using a random effects model to estimate the pooled prevalence with a 95% confidence interval (95%CI). Results A total of 412 eligible studies with 1 377 349 subjects were included. The pooled H. pylori prevalence was 44.2% (95%CI: 43.0–45.5%) in mainland China, with an estimated 589 million individuals infected with H. pylori. The prevalence was relatively high in the Northwest (51.8%, 95%CI: 47.5–56.1%), East (47.7%, 95%CI: 45.4–50.0%), and Southwest China (46.6%, 95%CI: 42.1–51.1%). The prevalence significantly decreased from 58.3% (95%CI: 50.7–65.5%) in the period 1983–1994 to 40.0% (95%CI: 38.2–41.8%) in the period 2015–2019. The prevalence increased with age, ranging from 28.0% (95%CI: 23.9–32.5%) in children and adolescents to 46.1% (95%CI: 44.5–47.6%) in adults. Conclusion Although the burden of H. pylori infections is still huge in China, the infection rate has been decreasing over the past decades. Targeted H. pylori eradication strategies may be considered in areas or populations with a high incidence of gastric cancer.
AbstractList Helicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically evaluated the longitudinal trends in H. pylori prevalence in China over the past decades.BACKGROUND AND AIMHelicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically evaluated the longitudinal trends in H. pylori prevalence in China over the past decades.We performed a systematic review of literature reporting the prevalence of H. pylori infection in mainland China from 1990 to 2019 in the PubMed and China National Knowledge Infrastructure databases. We conducted a meta-analysis of qualified studies using a random effects model to estimate the pooled prevalence with a 95% confidence interval (95%CI).METHODSWe performed a systematic review of literature reporting the prevalence of H. pylori infection in mainland China from 1990 to 2019 in the PubMed and China National Knowledge Infrastructure databases. We conducted a meta-analysis of qualified studies using a random effects model to estimate the pooled prevalence with a 95% confidence interval (95%CI).A total of 412 eligible studies with 1 377 349 subjects were included. The pooled H. pylori prevalence was 44.2% (95%CI: 43.0-45.5%) in mainland China, with an estimated 589 million individuals infected with H. pylori. The prevalence was relatively high in the Northwest (51.8%, 95%CI: 47.5-56.1%), East (47.7%, 95%CI: 45.4-50.0%), and Southwest China (46.6%, 95%CI: 42.1-51.1%). The prevalence significantly decreased from 58.3% (95%CI: 50.7-65.5%) in the period 1983-1994 to 40.0% (95%CI: 38.2-41.8%) in the period 2015-2019. The prevalence increased with age, ranging from 28.0% (95%CI: 23.9-32.5%) in children and adolescents to 46.1% (95%CI: 44.5-47.6%) in adults.RESULTSA total of 412 eligible studies with 1 377 349 subjects were included. The pooled H. pylori prevalence was 44.2% (95%CI: 43.0-45.5%) in mainland China, with an estimated 589 million individuals infected with H. pylori. The prevalence was relatively high in the Northwest (51.8%, 95%CI: 47.5-56.1%), East (47.7%, 95%CI: 45.4-50.0%), and Southwest China (46.6%, 95%CI: 42.1-51.1%). The prevalence significantly decreased from 58.3% (95%CI: 50.7-65.5%) in the period 1983-1994 to 40.0% (95%CI: 38.2-41.8%) in the period 2015-2019. The prevalence increased with age, ranging from 28.0% (95%CI: 23.9-32.5%) in children and adolescents to 46.1% (95%CI: 44.5-47.6%) in adults.Although the burden of H. pylori infections is still huge in China, the infection rate has been decreasing over the past decades. Targeted H. pylori eradication strategies may be considered in areas or populations with a high incidence of gastric cancer.CONCLUSIONAlthough the burden of H. pylori infections is still huge in China, the infection rate has been decreasing over the past decades. Targeted H. pylori eradication strategies may be considered in areas or populations with a high incidence of gastric cancer.
Background and Aim Helicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically evaluated the longitudinal trends in H. pylori prevalence in China over the past decades. Methods We performed a systematic review of literature reporting the prevalence of H. pylori infection in mainland China from 1990 to 2019 in the PubMed and China National Knowledge Infrastructure databases. We conducted a meta‐analysis of qualified studies using a random effects model to estimate the pooled prevalence with a 95% confidence interval (95%CI). Results A total of 412 eligible studies with 1 377 349 subjects were included. The pooled H. pylori prevalence was 44.2% (95%CI: 43.0–45.5%) in mainland China, with an estimated 589 million individuals infected with H. pylori. The prevalence was relatively high in the Northwest (51.8%, 95%CI: 47.5–56.1%), East (47.7%, 95%CI: 45.4–50.0%), and Southwest China (46.6%, 95%CI: 42.1–51.1%). The prevalence significantly decreased from 58.3% (95%CI: 50.7–65.5%) in the period 1983–1994 to 40.0% (95%CI: 38.2–41.8%) in the period 2015–2019. The prevalence increased with age, ranging from 28.0% (95%CI: 23.9–32.5%) in children and adolescents to 46.1% (95%CI: 44.5–47.6%) in adults. Conclusion Although the burden of H. pylori infections is still huge in China, the infection rate has been decreasing over the past decades. Targeted H. pylori eradication strategies may be considered in areas or populations with a high incidence of gastric cancer.
Helicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically evaluated the longitudinal trends in H. pylori prevalence in China over the past decades. We performed a systematic review of literature reporting the prevalence of H. pylori infection in mainland China from 1990 to 2019 in the PubMed and China National Knowledge Infrastructure databases. We conducted a meta-analysis of qualified studies using a random effects model to estimate the pooled prevalence with a 95% confidence interval (95%CI). A total of 412 eligible studies with 1 377 349 subjects were included. The pooled H. pylori prevalence was 44.2% (95%CI: 43.0-45.5%) in mainland China, with an estimated 589 million individuals infected with H. pylori. The prevalence was relatively high in the Northwest (51.8%, 95%CI: 47.5-56.1%), East (47.7%, 95%CI: 45.4-50.0%), and Southwest China (46.6%, 95%CI: 42.1-51.1%). The prevalence significantly decreased from 58.3% (95%CI: 50.7-65.5%) in the period 1983-1994 to 40.0% (95%CI: 38.2-41.8%) in the period 2015-2019. The prevalence increased with age, ranging from 28.0% (95%CI: 23.9-32.5%) in children and adolescents to 46.1% (95%CI: 44.5-47.6%) in adults. Although the burden of H. pylori infections is still huge in China, the infection rate has been decreasing over the past decades. Targeted H. pylori eradication strategies may be considered in areas or populations with a high incidence of gastric cancer.
Background and AimHelicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically evaluated the longitudinal trends in H. pylori prevalence in China over the past decades.MethodsWe performed a systematic review of literature reporting the prevalence of H. pylori infection in mainland China from 1990 to 2019 in the PubMed and China National Knowledge Infrastructure databases. We conducted a meta‐analysis of qualified studies using a random effects model to estimate the pooled prevalence with a 95% confidence interval (95%CI).ResultsA total of 412 eligible studies with 1 377 349 subjects were included. The pooled H. pylori prevalence was 44.2% (95%CI: 43.0–45.5%) in mainland China, with an estimated 589 million individuals infected with H. pylori. The prevalence was relatively high in the Northwest (51.8%, 95%CI: 47.5–56.1%), East (47.7%, 95%CI: 45.4–50.0%), and Southwest China (46.6%, 95%CI: 42.1–51.1%). The prevalence significantly decreased from 58.3% (95%CI: 50.7–65.5%) in the period 1983–1994 to 40.0% (95%CI: 38.2–41.8%) in the period 2015–2019. The prevalence increased with age, ranging from 28.0% (95%CI: 23.9–32.5%) in children and adolescents to 46.1% (95%CI: 44.5–47.6%) in adults.ConclusionAlthough the burden of H. pylori infections is still huge in China, the infection rate has been decreasing over the past decades. Targeted H. pylori eradication strategies may be considered in areas or populations with a high incidence of gastric cancer.
Author Li, Qian
Jin, Guangfu
Wei, Liqin
Cai, Pengpeng
Liu, Yaqian
Wang, Tianpei
Zhang, Yan
Yan, Caiwang
Ren, Shuai
Gu, Yuanliang
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  surname: Ren
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  organization: Baotou Medical College
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  organization: Nanjing Medical University
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  surname: Liu
  fullname: Liu, Yaqian
  organization: Nanjing Medical University
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  surname: Wang
  fullname: Wang, Tianpei
  organization: Nanjing Medical University
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  givenname: Yan
  surname: Zhang
  fullname: Zhang, Yan
  organization: Nanjing Medical University
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  givenname: Qian
  surname: Li
  fullname: Li, Qian
  organization: Nanjing Medical University
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  orcidid: 0000-0003-0249-5337
  surname: Jin
  fullname: Jin, Guangfu
  email: guangfujin@njmu.edu.cn
  organization: The Affiliated Cancer Hospital of Nanjing Medical University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34862656$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
2022 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
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Issue 3
Keywords meta-analysis
epidemiology
prevalence
Helicobacter pylori
China
Language English
License 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
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Notes This study was funded by the National Natural Science Foundation of China (82125033, 82003534 and 81872702) and Natural Science Foundation of Jiangsu Province (BK20200674).
Declaration of conflict of interest
Financial support
GJ designed the study and edited the manuscript; SR and PC reviewed papers and extracted relevant data; LW resolved disagreements; SR and CY performed statistical analysis and wrote the manuscript; YL, TW, YZ, QL, and YG reviewed data and provided comments or suggestions; GJ had primary responsibility for final content.
The authors declare no conflicts of interest.
Shuai Ren and Pengpeng Cai contributed equally to this study.
Author contributions
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Snippet Background and Aim Helicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically...
Helicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically evaluated the...
Background and AimHelicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically...
Helicobacter pylori (H. pylori) infection rates have been changing with different populations and geographic areas. We systematically evaluated the...
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SubjectTerms China
China - epidemiology
epidemiology
Gastric cancer
Helicobacter Infections - epidemiology
Helicobacter pylori
Humans
Infections
Meta-analysis
Prevalence
Systematic review
Title Prevalence of Helicobacter pylori infection in China: A systematic review and meta‐analysis
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https://www.ncbi.nlm.nih.gov/pubmed/34862656
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