Nicotinamide phosphoribosyltransferase secreted from microglia via exosome during ischemic injury

Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of the salvage pathway of nicotinamide adenine dinucleotide synthesis. NAMPT can also be secreted and functions as a cytokine. We have previously shown that in the brain, NAMPT expression and secretion can be induced in microglia upon...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 150; no. 6; pp. 723 - 737
Main Authors:	Lu, Yun‐Bi, Chen, Chen‐Xiang, Huang, Jing, Tian, Yu‐Xin, Xie, Xian, Yang, Ping, Wu, Ming, Tang, Chun, Zhang, Wei‐Ping
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.09.2019
Subjects:	Adenine Animals Autophagy Brain - metabolism Brain Ischemia - metabolism Butanol Calcium (intracellular) Calcium ions Centrifugation Cytokines - metabolism Deprivation Electron microscopy Endosomes exosome Exosomes - metabolism Glucose - deficiency Golgi apparatus Hypoxia Inflammation Injuries Ischemia ischemic injury Microglia Microglia - metabolism Morphology NAD neuroinflammation Nicotinamide Nicotinamide adenine dinucleotide Nicotinamide phosphoribosyltransferase Nicotinamide Phosphoribosyltransferase - metabolism Phagocytosis Phospholipase Phospholipase D Phosphoribosyltransferase Physical characteristics Rats Rats, Sprague-Dawley siRNA Vesicles Western blotting Wortmannin nicotinamide phosphoribosyltransferase neuroinflammation exosome microglia ischemic injury
ISSN:	0022-3042, 1471-4159, 1471-4159
Online Access:	Get full text
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