Parasutterella, in association with irritable bowel syndrome and intestinal chronic inflammation

Background and Aim Irritable bowel syndrome (IBS) is a highly prevalent chronic functional gastrointestinal disorder. Recent studies have showed increasing important role of gut microbiota in the pathophysiological changes of IBS. Our study aims to elaborate the association between intestinal flora...

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Published in:Journal of gastroenterology and hepatology Vol. 33; no. 11; pp. 1844 - 1852
Main Authors: Chen, Yan‐Jie, Wu, Hao, Wu, Sheng‐Di, Lu, Nan, Wang, Yi‐Ting, Liu, Hai‐Ning, Dong, Ling, Liu, Tao‐Tao, Shen, Xi‐Zhong
Format: Journal Article
Language:English
Published: Australia Wiley Subscription Services, Inc 01.11.2018
Subjects:
Adolescent
Adult
Aged
Animals
Betaproteobacteria - genetics
Betaproteobacteria - isolation & purification
Betaproteobacteria - pathogenicity
chronic intestinal inflammation
Colon
Defecation
Digestive system
Disease Models, Animal
Disease Progression
DNA, Bacterial - isolation & purification
Fecal Microbiota Transplantation
Feces
Feces - microbiology
Gastrointestinal Microbiome
Gastrointestinal tract
gut microbiota
High-Throughput Nucleotide Sequencing
Humans
Inflammation
Intestinal microflora
Intestine
Irritable bowel syndrome
irritable bowel syndrome (IBS)
Irritable Bowel Syndrome - etiology
Irritable Bowel Syndrome - microbiology
Male
Mice, Inbred C57BL
Microbiota
Microorganisms
Middle Aged
Parasutterella
Real-Time Polymerase Chain Reaction
Young Adult
chronic intestinal inflammation
irritable bowel syndrome (IBS)
Parasutterella
gut microbiota
ISSN:0815-9319, 1440-1746, 1440-1746
Online Access:Get full text
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Summary:Background and Aim Irritable bowel syndrome (IBS) is a highly prevalent chronic functional gastrointestinal disorder. Recent studies have showed increasing important role of gut microbiota in the pathophysiological changes of IBS. Our study aims to elaborate the association between intestinal flora with the genesis and the development of IBS. Methods Illumina high‐throughput sequencing technology was applied to investigate microbial communities of IBS patients and healthy donors. Stool specimens from the IBS‐D patients were equally premixed and implanted into germ free C57B/6 mice to construct IBS animal model, and the normal group was also transplanted with normal premixed feces. The post‐transplant defecation and intra‐epithelial lymphocyte counts were evaluated. Microbial communities were also checked by the illumina high‐throughput sequencing technology. Results Fifteen genuses significantly different were found expressed in the gut flora of IBS patients, and six genuses showed significantly different abundances between the stool specimens of mice of IBS group and normal group. Among these differences, Parasutterella expression was remarkably different in both screening and validation experiments and also related to chronic intestinal inflammation; therefore, Parasutterella expression is considered in association with the development and progression of IBS. Conclusion Parasutterella may be related with the genesis and development of IBS and also associated with chronic intestinal inflammation in IBS patients.
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ISSN:0815-9319
1440-1746
1440-1746
DOI:10.1111/jgh.14281