Single‐nucleotide polymorphism in chronic rhinosinusitis: A systematic review

Objectives We performed a systematic review on single‐nucleotide polymorphisms and risk‐related chronic rhinosinusitis. Design and Setting A comprehensive review of the last 20 years’ English language literature regarding chronic rhinosinusitis and single‐nucleotide polymorphisms was performed. We i...

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Vydané v:Clinical otolaryngology Ročník 47; číslo 1; s. 14 - 23
Hlavní autori: Antonino, Maniaci, Nicolò, Musso, Jerome Renee, Lechien, Federico, Merlino, Chiara, Viglianisi, Stefano, Stracquadanio, Maria, Santagati, Salvatore, Cocuzza, Antonio, Bonanno, Calvo‐Henriquez, Christian, Stefania, Stefani, La Mantia, Ignazio
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Wiley Subscription Services, Inc 01.01.2022
Predmet:
Asthma
Atopy
Chronic Disease
chronic rhinosinusitis
Comorbidity
Eosinophilia
Genetic Predisposition to Disease
Humans
metagenomics
Nucleotides
Pathogenesis
Polymorphism
Polymorphism, Single Nucleotide
Polyps
Rhinitis
Rhinitis - genetics
Rhinosinusitis
sequencing
Single-nucleotide polymorphism
Sinusitis
Sinusitis - genetics
SNP
Systematic review
chronic rhinosinusitis
polymorphism
SNP
metagenomics
sequencing
ISSN:1749-4478, 1749-4486, 1749-4486
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Popis
Shrnutí:Objectives We performed a systematic review on single‐nucleotide polymorphisms and risk‐related chronic rhinosinusitis. Design and Setting A comprehensive review of the last 20 years’ English language literature regarding chronic rhinosinusitis and single‐nucleotide polymorphisms was performed. We included in the synthesis all the papers reporting gene variation implicated in the pathogenesis of chronic inflammation and polyps. Results We found 12 papers with 9127 patients, of which 2739 CRS cases and 6388 controls. The major comorbidities reported related to chronic rhinosinusitis were atopy in 4555 (49.9%), asthma in 4594 (50.33%), Samter Triad in 448 (4.9%) and eosinophilia in 391 subjects (4.28%). Conclusion Our systematic review revealed the major SNPs significantly associated with chronic rhinosinusitis and the specific pathways involved. Given the presence of different extraction methods and samples sequencing, further studies with larger courts are necessary to identify significative single‐nucleotide polymorphisms.
Bibliografia:Funding information
This research received no external funding
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ObjectType-Evidence Based Healthcare-1
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ISSN:1749-4478
1749-4486
1749-4486
DOI:10.1111/coa.13870