The biology of normal bone remodelling

During life, bone undergoes modelling and remodelling in order to grow or change shape. Bone modelling is the process by which bones change shape or size in response to physiologic influences or mechanical forces that are encountered by the skeleton, while bone remodelling takes place so that bone m...

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Bibliographic Details
Published in:European journal of cancer care Vol. 26; no. 6; pp. e12740 - n/a
Main Author: Katsimbri, P.
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01.11.2017
Subjects:
Adolescents
Body composition
Bone Development - physiology
Bone growth
Bone remodeling
Bone Remodeling - physiology
bone remodelling
Bone Resorption
Bones
Calcification, Physiologic - physiology
Cartilage
Cartilage - growth & development
Child development
Children
Homeostasis
Human growth
Humans
Mineralization
Modelling
osteoblast
Osteoblasts - physiology
osteoclasts
Osteoclasts - physiology
osteocytes
Osteocytes - physiology
Osteogenesis
Osteogenesis - physiology
Skeleton
Stress, Mechanical
Teenagers
bone remodelling
osteoblast
osteocytes
osteoclasts
ISSN:0961-5423, 1365-2354, 1365-2354
Online Access:Get full text
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Summary:During life, bone undergoes modelling and remodelling in order to grow or change shape. Bone modelling is the process by which bones change shape or size in response to physiologic influences or mechanical forces that are encountered by the skeleton, while bone remodelling takes place so that bone may maintain its strength and mineral homeostasis. During early childhood, both bone modelling (the formation and shaping of bone) and bone remodelling (the replacement or renewal of old bone) occur. The predominant process in childhood is bone modelling, while in adulthood bone remodelling predominates. The exception to this is after a fracture when we see massive increases in bone formation. During childhood and adolescence growth occurs in the bones longitudinally and radially, while in the growth plates it occurs longitudinally, thus promoting growth in size. Cartilage first proliferates in the epiphyseal and metaphyseal areas of long bones before undergoing mineralisation to form new bone.
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ISSN:0961-5423
1365-2354
1365-2354
DOI:10.1111/ecc.12740