Exploring the Pharmacogenomic Map of Croatia: PGx Clustering of 522-Patient Cohort Based on UMAP + HDBSCAN Algorithm

Pharmacogenetics is a branch of genomic medicine aiming to personalize drug prescription guidelines based on individual genetic information. This concept might lead to a reduction in adverse drug reactions, which place a heavy burden on individual patients’ health and the economy of the healthcare s...

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Vydáno v:	International journal of molecular sciences Ročník 26; číslo 2; s. 589
Hlavní autoři:	Brlek, Petar, Bulić, Luka, Mršić, Leo, Sokač, Mateo, Brenner, Eva, Matišić, Vid, Skelin, Andrea, Bach-Rojecky, Lidija, Primorac, Dragan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 12.01.2025 MDPI
Témata:	Adult Aged Algorithms Cluster Analysis Clustering Cohort Studies Croatia Cytochrome P-450 CYP2D6 - genetics Data analysis Decision Trees Drug therapy Enzymes Female Genes Genotype Genotype & phenotype Humans Liver-Specific Organic Anion Transporter 1 - genetics Machine learning Male Medical research Medicine, Experimental Metabolism Middle Aged Patients Pharmacogenetics Pharmacogenetics - methods Pharmacogenomic Testing Precision Medicine Side effects Technology application Toxicity Croatia adverse drug reactions dimensionality reduction unsupervised machine learning hierarchical density-based clustering pharmacogenetics
ISSN:	1422-0067, 1661-6596, 1422-0067
On-line přístup:	Získat plný text
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