Assessing the Gold Standard — Lessons from the History of RCTs
Over the past 70 years, randomized, controlled trials (RCTs) have reshaped medical knowledge and practice. Popularized by mid-20th-century clinical researchers and statisticians aiming to reduce bias and enhance the accuracy of clinical experimentation, RCTs have often functioned well in that role....
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| Veröffentlicht in: | The New England journal of medicine Jg. 374; H. 22; S. 2175 - 2181 |
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| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
Massachusetts Medical Society
02.06.2016
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| Schlagworte: | |
| ISSN: | 0028-4793, 1533-4406 |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Over the past 70 years, randomized, controlled trials (RCTs) have reshaped medical knowledge and practice. Popularized by mid-20th-century clinical researchers and statisticians aiming to reduce bias and enhance the accuracy of clinical experimentation, RCTs have often functioned well in that role. Yet the past seven decades also bear witness to many limitations of this new “gold standard.” The scientific and political history of RCTs offers lessons regarding the complexity of medicine and disease and the economic and political forces that shape the production and circulation of medical knowledge.
The Rise of RCTs
Physicians and medical researchers have attempted for millennia . . . |
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| Bibliographie: | SourceType-Scholarly Journals-1 ObjectType-Commentary-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0028-4793 1533-4406 |
| DOI: | 10.1056/NEJMms1604593 |