Levofloxacin Preventive Treatment in Children Exposed to MDR Tuberculosis

In this randomized, controlled trial involving children with household exposure to multidrug-resistant tuberculosis, levofloxacin led to a lower incidence of tuberculosis than placebo, but the difference was not significant.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 391; no. 24; pp. 2315 - 2326
Main Authors: Hesseling, Anneke C., Purchase, Susan E., Martinson, Neil A., Fairlie, Lee, Schaaf, H. Simon, Brigden, Joanna, Staples, Suzanne, Gibb, Diana M., Garcia-Prats, Anthony, Conradie, Francesca, McGowan, Charlotte, Layton, Charlotte, Batist, Elize, Demers, Anne-Marie, Nyamathe, Samukelisiwe, Frigati, Lisa, Turner, Rebecca, Duong, Trinh, Seddon, James A.
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 19.12.2024
Subjects:
Adolescent
Adolescent Medicine
Adverse events
Age
Antibiotics
Antitubercular Agents - administration & dosage
Antitubercular Agents - adverse effects
Caregivers
Child
Child, Preschool
Childhood Diseases
Children
Disease prevention
Double-Blind Method
Drug dosages
Female
Global Health
HIV
HIV Infections - complications
Human immunodeficiency virus
Humans
Incidence
Infant
Infections
Infectious Disease
Infectious Disease General
Interferon-gamma Release Tests
Kaplan-Meier Estimate
Levofloxacin
Levofloxacin - administration & dosage
Levofloxacin - adverse effects
Male
Multidrug resistance
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - immunology
Mycobacterium tuberculosis - isolation & purification
Patients
Pediatrics
Pediatrics General
Placebos
Sensitivity analysis
South Africa - epidemiology
Teenagers
Tuberculosis
Tuberculosis, Multidrug-Resistant - diagnosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - prevention & control
Tuberculosis, Multidrug-Resistant - transmission
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - prevention & control
Tuberculosis, Pulmonary - transmission
γ-Interferon
South Africa
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:In this randomized, controlled trial involving children with household exposure to multidrug-resistant tuberculosis, levofloxacin led to a lower incidence of tuberculosis than placebo, but the difference was not significant.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa2314318