Levofloxacin Preventive Treatment in Children Exposed to MDR Tuberculosis

In this randomized, controlled trial involving children with household exposure to multidrug-resistant tuberculosis, levofloxacin led to a lower incidence of tuberculosis than placebo, but the difference was not significant.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine Jg. 391; H. 24; S. 2315 - 2326
Hauptverfasser:	Hesseling, Anneke C., Purchase, Susan E., Martinson, Neil A., Fairlie, Lee, Schaaf, H. Simon, Brigden, Joanna, Staples, Suzanne, Gibb, Diana M., Garcia-Prats, Anthony, Conradie, Francesca, McGowan, Charlotte, Layton, Charlotte, Batist, Elize, Demers, Anne-Marie, Nyamathe, Samukelisiwe, Frigati, Lisa, Turner, Rebecca, Duong, Trinh, Seddon, James A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Massachusetts Medical Society 19.12.2024
Schlagworte:	Adolescent Adolescent Medicine Adverse events Age Antibiotics Antitubercular Agents - administration & dosage Antitubercular Agents - adverse effects Caregivers Child Child, Preschool Childhood Diseases Children Disease prevention Double-Blind Method Drug dosages Female Global Health HIV HIV Infections - complications Human immunodeficiency virus Humans Incidence Infant Infections Infectious Disease Infectious Disease General Interferon-gamma Release Tests Kaplan-Meier Estimate Levofloxacin Levofloxacin - administration & dosage Levofloxacin - adverse effects Male Multidrug resistance Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - isolation & purification Patients Pediatrics Pediatrics General Placebos Sensitivity analysis South Africa - epidemiology Teenagers Tuberculosis Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - prevention & control Tuberculosis, Multidrug-Resistant - transmission Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - prevention & control Tuberculosis, Pulmonary - transmission γ-Interferon South Africa
ISSN:	0028-4793, 1533-4406, 1533-4406
Online-Zugang:	Volltext
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