Key substrate recognition residues in the active site of cystathionine beta‐synthase from Toxoplasma gondii

Cystathionine β‐synthase (CBS) catalyzes the condensation of l ‐serine and l ‐homocysteine to give l ‐cystathionine in the transsulfuration pathway. Recently, a few O ‐acetylserine ( l ‐OAS)‐dependent CBSs (OCBSs) have been found in bacteria that can exclusively function with l ‐OAS. CBS from Toxopl...

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Bibliographic Details

Published in:	Proteins, structure, function, and bioinformatics Vol. 91; no. 10; pp. 1383 - 1393
Main Authors:	Conter, Carolina, Favretto, Filippo, Dominici, Paola, Martinez‐Cruz, Luis Alfonso, Astegno, Alessandra
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.10.2023
Subjects:	Homocysteine Hydrophobicity Hydroxyl groups Mutation Protein structure Residues Serine Substrate specificity Substrates Toxoplasma gondii Toxoplasma gondii cystathionine β-synthase mutagenesis enzyme kinetics substrate specificity
ISSN:	0887-3585, 1097-0134, 1097-0134
Online Access:	Get full text
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