Synthetic biology moving into the clinic

Synthetic biology is an emerging field focused on engineering biomolecular systems and cellular capabilities for a variety of applications. Substantial progress began a little over a decade ago with the creation of synthetic gene networks inspired by electrical engineering. Since then, the field has...

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Vydáno v:Science (American Association for the Advancement of Science) Ročník 333; číslo 6047; s. 1248
Hlavní autoři: Ruder, Warren C, Lu, Ting, Collins, James J
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 02.09.2011
Témata:
Animals
Bacterial Infections - prevention & control
Bacterial Infections - therapy
Cell Transplantation
Culicidae - genetics
Gene Regulatory Networks
Genetic Engineering
Humans
Insect Vectors - genetics
Malaria - prevention & control
Malaria - transmission
Metagenome - genetics
Neoplasms - therapy
Regenerative Medicine - methods
Synthetic Biology - methods
Vaccines, Synthetic
ISSN:1095-9203, 1095-9203
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Shrnutí:Synthetic biology is an emerging field focused on engineering biomolecular systems and cellular capabilities for a variety of applications. Substantial progress began a little over a decade ago with the creation of synthetic gene networks inspired by electrical engineering. Since then, the field has designed and built increasingly complex circuits and constructs and begun to use these systems in a variety of settings, including the clinic. These efforts include the development of synthetic biology therapies for the treatment of infectious diseases and cancer, as well as approaches in vaccine development, microbiome engineering, cell therapy, and regenerative medicine. Here, we highlight advances in the biomedical application of synthetic biology and discuss the field's clinical potential.
Bibliografie:ObjectType-Article-1
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ObjectType-Review-3
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.1206843