Atherosclerotic Plaque Healing

Atherosclerotic plaque rupture and erosion result in acute coronary syndromes. Plaque healing after initial disruption has been less extensively studied. Reviewed are mechanisms and phenotypic features of plaque healing, its role in clinical events, and therapeutic implications.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 383; no. 9; pp. 846 - 857
Main Authors: Vergallo, Rocco, Crea, Filippo
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 27.08.2020
Subjects:
Acute Coronary Syndrome - etiology
Acute coronary syndromes
Arteriosclerosis
Atherosclerosis
Blood clots
Blood platelets
Collagen
Coronary Thrombosis - complications
Coronary Thrombosis - physiopathology
Extracellular matrix
Growth factors
Humans
Inflammation - physiopathology
Lipids
Magnetic resonance imaging
Plaque, Atherosclerotic - diagnostic imaging
Plaque, Atherosclerotic - pathology
Plaque, Atherosclerotic - physiopathology
Rupture, Spontaneous - complications
Rupture, Spontaneous - physiopathology
Thrombosis
Tomography, Optical Coherence
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:Atherosclerotic plaque rupture and erosion result in acute coronary syndromes. Plaque healing after initial disruption has been less extensively studied. Reviewed are mechanisms and phenotypic features of plaque healing, its role in clinical events, and therapeutic implications.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMra2000317