The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation

Considering the role PARPs play in inflammation, we assessed the effect of PARP inhibition in an inflammatory skin condition, psoriasis, to explore novel avenues for the potential repurposing of PARP inhibitors that are currently used in tumour therapy. The imiquimod (IMQ)-induced model of psoriasis...

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Bibliographic Details

Published in:	Frontiers in pharmacology Vol. 16; p. 1519066
Main Authors:	Molnár, Petra, Demény, Máté Ágoston, Várkonyi, Beáta, Polgár, Zsuzsanna, Pór, Ágnes, Kovács, Ilona, Szegedi, Andrea, Szöllősi, Attila Gábor, Szántó, Magdolna
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 19.02.2025
Subjects:	apoptosis drug repurposing mitochondria PARP inhibitor Pharmacology psoriasis terminal differentiation apoptosis drug repurposing terminal differentiation mitochondria psoriasis PARP inhibitor
ISSN:	1663-9812, 1663-9812
Online Access:	Get full text
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