Time-Lapse Imaging in IVF: Bridging the Gap Between Promises and Clinical Realities
Time-lapse imaging (TLI) has emerged as a transformative technology in in vitro fertilization (IVF). This is because it offers continuous, non-invasive embryo assessment through morphokinetic profiling. It demonstrates key advantages such as reduced embryologist subjectivity, detection of dynamic an...
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| Vydáno v: | International journal of molecular sciences Ročník 26; číslo 19; s. 9609 |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Switzerland
MDPI AG
01.10.2025
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| ISSN: | 1422-0067, 1661-6596, 1422-0067 |
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| Abstract | Time-lapse imaging (TLI) has emerged as a transformative technology in in vitro fertilization (IVF). This is because it offers continuous, non-invasive embryo assessment through morphokinetic profiling. It demonstrates key advantages such as reduced embryologist subjectivity, detection of dynamic anomalies, and improved implantation rates in niche populations. However, its clinical utility remains debated. Large trials and meta-analyses reveal no universal improvement in live birth rates compared to conventional methods. Key challenges underlying the outcome include algorithm generalizability, lab-specific protocol variability, and high costs. Nevertheless, TLI shows promise in specific contexts. For instance, Preimplantation Genetic Testing for Aneuploidies (PGT-A) cycles where it reduces unnecessary biopsies by predicting euploidy. However, even in this, its benefits are marginal in unselected populations. This review synthesizes evidence to highlight that TLI’s value is context-dependent, not universal. As such, adoption must be cautious to avoid resource misallocation without significant IVF outcome improvements. In future, personalized protocols, integration with non-invasive biomarkers, and multicenter collaboration are crucial to optimize TLI’s potential in assisted reproduction. |
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| AbstractList | Time-lapse imaging (TLI) has emerged as a transformative technology in in vitro fertilization (IVF). This is because it offers continuous, non-invasive embryo assessment through morphokinetic profiling. It demonstrates key advantages such as reduced embryologist subjectivity, detection of dynamic anomalies, and improved implantation rates in niche populations. However, its clinical utility remains debated. Large trials and meta-analyses reveal no universal improvement in live birth rates compared to conventional methods. Key challenges underlying the outcome include algorithm generalizability, lab-specific protocol variability, and high costs. Nevertheless, TLI shows promise in specific contexts. For instance, Preimplantation Genetic Testing for Aneuploidies (PGT-A) cycles where it reduces unnecessary biopsies by predicting euploidy. However, even in this, its benefits are marginal in unselected populations. This review synthesizes evidence to highlight that TLI's value is context-dependent, not universal. As such, adoption must be cautious to avoid resource misallocation without significant IVF outcome improvements. In future, personalized protocols, integration with non-invasive biomarkers, and multicenter collaboration are crucial to optimize TLI's potential in assisted reproduction. |
| Audience | Academic |
| Author | Magoń, Tomasz Pluta, Tomasz Zowczak, Joanna Bołkun, Igor Mrugacz, Grzegorz Skórka, Ewelina Golka, Beata Fedak, Olena Cieśla, Paulina Korowaj, Izabela |
| Author_xml | – sequence: 1 givenname: Grzegorz surname: Mrugacz fullname: Mrugacz, Grzegorz – sequence: 2 givenname: Igor surname: Bołkun fullname: Bołkun, Igor – sequence: 3 givenname: Tomasz surname: Magoń fullname: Magoń, Tomasz – sequence: 4 givenname: Izabela surname: Korowaj fullname: Korowaj, Izabela – sequence: 5 givenname: Beata surname: Golka fullname: Golka, Beata – sequence: 6 givenname: Tomasz surname: Pluta fullname: Pluta, Tomasz – sequence: 7 givenname: Olena surname: Fedak fullname: Fedak, Olena – sequence: 8 givenname: Paulina surname: Cieśla fullname: Cieśla, Paulina – sequence: 9 givenname: Joanna surname: Zowczak fullname: Zowczak, Joanna – sequence: 10 givenname: Ewelina surname: Skórka fullname: Skórka, Ewelina |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/41096871$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Algorithms Artificial intelligence Comparative analysis Embryo Implantation Embryology Embryonic development Embryos Female Fertilization in vitro Fertilization in Vitro - methods Genetic screening Humans In vitro fertilization Microscopy Morphology Pregnancy Preimplantation Diagnosis - methods Proprietary Subjectivity Time-Lapse Imaging - methods |
| Title | Time-Lapse Imaging in IVF: Bridging the Gap Between Promises and Clinical Realities |
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