Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma

Differentiation of antigen-activated B cells into proproliferative germinal center (GC) B cells depends on the activity of the transcription factors myelocytoma (MYC) and B-cell lymphoma 6 (BCL6), and the epigenetic writers disruptor of telomeric silencing 1-like (DOT1L) and enhancer of zeste homolo...

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Bibliographic Details
Published in:	Blood Vol. 145; no. 16; p. 1802
Main Authors:	Göbel, Camiel, Niccolai, Rachele, de Groot, Marnix H P, Jayachandran, Jayashree, Traets, Joleen, Kloosterman, Daan J, Gregoricchio, Sebastian, Morris, Ben, Kreft, Maaike, Song, Ji-Ying, Azarang, Leyla, Kasa, Eirini, Oskam, Nienke, de Groot, Daniel, Hoekman, Liesbeth, Bleijerveld, Onno B, Kersten, Marie José, Aslam, Muhammad A, van Leeuwen, Fred, Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	United States 17.04.2025
Subjects:	Animals Cell Differentiation Cell Line, Tumor Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors Enhancer of Zeste Homolog 2 Protein - genetics Enhancer of Zeste Homolog 2 Protein - metabolism Epigenesis, Genetic Gene Expression Regulation, Neoplastic - drug effects Germinal Center - drug effects Germinal Center - metabolism Germinal Center - pathology Histone-Lysine N-Methyltransferase - antagonists & inhibitors Humans Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Mice
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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