Identifying extra pulmonary vein targets for persistent atrial fibrillation ablation: bridging advanced and conventional mapping techniques

Abstract Aims Advanced technologies such as charge density mapping (CDM) show promise in guiding adjuvant ablation in patients with persistent atrial fibrillation (AF); however, their limited availability restricts widespread adoption. We sought to determine whether regions of the left atrium contai...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Europace (London, England) Ročník 27; číslo 4
Hlavní autoři: Sharp, Alexander J, Pope, Michael T, Briosa e Gala, Andre, Varini, Richard, Banerjee, Abhirup, Betts, Timothy R
Médium: Journal Article
Jazyk:angličtina
Vydáno: UK Oxford University Press 28.03.2025
Témata:
Action Potentials
Aged
Atrial Fibrillation - diagnosis
Atrial Fibrillation - physiopathology
Atrial Fibrillation - surgery
Catheter Ablation - methods
Clinical Research
Electrophysiologic Techniques, Cardiac - methods
Female
Heart Atria - physiopathology
Heart Atria - surgery
Heart Rate
Humans
Male
Middle Aged
Predictive Value of Tests
Pulmonary Veins - physiopathology
Pulmonary Veins - surgery
Treatment Outcome
Low-voltage areas
Electroanatomic voltage mapping
Charge density mapping
Conduction velocity
Catheter ablation
Persistent atrial fibrillation
ISSN:1099-5129, 1532-2092, 1532-2092
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Abstract Aims Advanced technologies such as charge density mapping (CDM) show promise in guiding adjuvant ablation in patients with persistent atrial fibrillation (AF); however, their limited availability restricts widespread adoption. We sought to determine whether regions of the left atrium containing CDM-identified pivoting and rotational propagation patterns during AF could also be reliably identified using more conventional contact mapping techniques. Methods and results Twenty-two patients undergoing de novo ablation of persistent AF underwent both CDM and electroanatomic voltage mapping during AF and sinus rhythm with multiple pacing protocols. Through the use of a left atrium statistical shape model, the location of distinctive propagation patterns identified by CDM was compared with low-voltage areas (LVAs) and regions of slow conduction velocity (CV). Neither LVA nor CV mapping during paced rhythms reliably identified regions containing CDM propagation patterns. Conduction velocity mapping during AF did correlate with these regions (ρ = −0.63, P < 0.0001 for pivoting patterns; ρ = −0.54, P < 0.0001 for rotational patterns). These propagation patterns consistently occurred in two specific anatomical regions across patients: the anteroseptal and inferoposterior walls of the left atrium. Conclusion Mapping techniques during paced rhythms do not reliably correspond with regions of CDM-identified propagation patterns in persistent AF. However, these propagation patterns are consistently observed in two specific anatomical regions, suggesting a predisposition to abnormal electrophysiological properties. While further research is needed, these regions may serve as promising targets for empirical ablation, potentially reducing the reliance on complex mapping techniques. Graphical Abstract Graphical Abstract
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conflict of interest: A.J.S. received research grant from Acutus Medical. M.T.B.P. and T.R.B. have received honoraria from Acutus Medical. All remaining authors have declared no conflicts of interest.
Abhirup Banerjee and Timothy R Betts contributed equally to the study.
ISSN:1099-5129
1532-2092
1532-2092
DOI:10.1093/europace/euaf048