Intranasal Delivery of BACE1 siRNA and Rapamycin by Dual Targets Modified Nanoparticles for Alzheimer's Disease Therapy

Alzheimer's disease (AD), as a progressive and irreversible brain disorder, remains the most universal neurodegenerative disease. No effective therapeutic methods are established yet due to the hindrance of the blood‐brain barrier (BBB) and the complex pathological condition of AD.  Therefore,...

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Bibliographic Details

Published in:	Small (Weinheim an der Bergstrasse, Germany) Vol. 18; no. 30; pp. e2203182 - n/a
Main Authors:	Yang, Xiaotong, Yang, Wenqin, Xia, Xue, Lei, Ting, Yang, Zhihang, Jia, Wenfeng, Zhou, Yang, Cheng, Guo, Gao, Huile
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley Subscription Services, Inc 01.07.2022
Subjects:	Agglomeration Aleuria aurantia lectin Alzheimer's disease amyloid‐β autophagy Binding Brain Cognition intranasal administration Nanoparticles Nanotechnology Peptides Rapamycin Toxicity
ISSN:	1613-6810, 1613-6829, 1613-6829
Online Access:	Get full text
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