A micronutrient with major effects on cancer cell viability

Selenium is a micronutrient essential for the generation of selenoproteins, which function predominantly by detoxifying cellular reactive oxygen species. In this issue, Carlisle et al. describe a novel mechanism whereby perturbing selenium utilization via inhibition of SEPHS2, a component of the sel...

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Vydané v:Nature metabolism Ročník 2; číslo 7; s. 564 - 565
Hlavní autori: Kapara, Anastasia, Vannini, Alessandro, Peck, Barrie
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 01.07.2020
Nature Publishing Group
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631/443/319
631/67/1059
631/67/1347
631/67/2327
Ablation
Biomarkers
Biomedical and Life Sciences
Breast cancer
Cell death
Cell viability
CRISPR
Ferroptosis
Genomes
Glutathione
Kinases
Life Sciences
Localization
Metabolism
Micronutrients
News & Views
news-and-views
Proteins
Reactive oxygen species
RNA polymerase
Selenide
Selenium
Selenocysteine
Selenoproteins
Transfer RNA
ISSN:2522-5812, 2522-5812
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Shrnutí:Selenium is a micronutrient essential for the generation of selenoproteins, which function predominantly by detoxifying cellular reactive oxygen species. In this issue, Carlisle et al. describe a novel mechanism whereby perturbing selenium utilization via inhibition of SEPHS2, a component of the selenocysteine-biosynthesis pathway, results in selenide poisoning and cancer cell death.
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ISSN:2522-5812
2522-5812
DOI:10.1038/s42255-020-0244-3