A micronutrient with major effects on cancer cell viability

Selenium is a micronutrient essential for the generation of selenoproteins, which function predominantly by detoxifying cellular reactive oxygen species. In this issue, Carlisle et al. describe a novel mechanism whereby perturbing selenium utilization via inhibition of SEPHS2, a component of the sel...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature metabolism Jg. 2; H. 7; S. 564 - 565
Hauptverfasser: Kapara, Anastasia, Vannini, Alessandro, Peck, Barrie
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.07.2020
Nature Publishing Group
Schlagworte:
631/443/319
631/67/1059
631/67/1347
631/67/2327
Ablation
Biomarkers
Biomedical and Life Sciences
Breast cancer
Cell death
Cell viability
CRISPR
Ferroptosis
Genomes
Glutathione
Kinases
Life Sciences
Localization
Metabolism
Micronutrients
News & Views
news-and-views
Proteins
Reactive oxygen species
RNA polymerase
Selenide
Selenium
Selenocysteine
Selenoproteins
Transfer RNA
ISSN:2522-5812, 2522-5812
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract Selenium is a micronutrient essential for the generation of selenoproteins, which function predominantly by detoxifying cellular reactive oxygen species. In this issue, Carlisle et al. describe a novel mechanism whereby perturbing selenium utilization via inhibition of SEPHS2, a component of the selenocysteine-biosynthesis pathway, results in selenide poisoning and cancer cell death.
AbstractList Selenium is a micronutrient essential for the generation of selenoproteins, which function predominantly by detoxifying cellular reactive oxygen species. In this issue, Carlisle et al. describe a novel mechanism whereby perturbing selenium utilization via inhibition of SEPHS2, a component of the selenocysteine-biosynthesis pathway, results in selenide poisoning and cancer cell death.
Author Vannini, Alessandro
Peck, Barrie
Kapara, Anastasia
Author_xml – sequence: 1
  givenname: Anastasia
  surname: Kapara
  fullname: Kapara, Anastasia
  organization: Translational Cancer Metabolism Lab, Centre for Tumour Biology, Barts Cancer Institute (BCI), Cancer Research UK Centre of Excellence, Queen Mary University of London
– sequence: 2
  givenname: Alessandro
  surname: Vannini
  fullname: Vannini, Alessandro
  organization: The Institute of Cancer Research (ICR), Fondazione Human Technopole, Structural Biology Research Centre
– sequence: 3
  givenname: Barrie
  orcidid: 0000-0002-6687-8495
  surname: Peck
  fullname: Peck, Barrie
  email: b.peck@qmul.ac.uk
  organization: Translational Cancer Metabolism Lab, Centre for Tumour Biology, Barts Cancer Institute (BCI), Cancer Research UK Centre of Excellence, Queen Mary University of London, The Institute of Cancer Research (ICR)
BookMark eNp9kM1KAzEURoNUsNY-gLsBN25Gk5tkJsFVKf5BwY2uQ5pmNGUmU5NU6dubMoJSUEhIFudcvvudopHvvUXonOArgqm4jgyA8xIDzpexkh6hMXCAkgsCo1__EzSNcY0xBkIYATlGN7Oicyb0fpuCsz4Vny69FZ1e96GwTWNNikXvC6O9saEwtm2LD6eXrnVpd4aOG91GO_1-J-jl7vZ5_lAunu4f57NFaSiTqZQrLivgoqamFlKsNKc1tyvQALU0TOiaNaC5wVWzkqS21CxtxaUQlgGFRtMJuhzmbkL_vrUxqc7FfRTtbb-NChhURJB8MnpxgK77bfA5naIAFRaikjhT9UDlxWMMtlHGJZ1c71PQrlUEq32vauhV5V7VvldFs0kOzE1wnQ67fx0YnJhZ_2rDT6a_pS9l7Ym_
CitedBy_id crossref_primary_10_1002_cbin_11506
Cites_doi 10.1038/s41586-019-1705-2
10.1038/nature24297
10.1016/j.cell.2013.12.010
10.1089/crispr.2019.0018
10.1038/s41467-019-09277-9
10.3109/10715761003667554
10.1371/journal.pmed.1000315
10.1038/s41388-018-0315-z
10.1016/j.cell.2015.11.005
10.1038/s41586-019-1707-0
10.1200/JCO.19.01203
10.1038/s42255-020-0224-7
ContentType Journal Article
Copyright Springer Nature Limited 2020
Copyright Nature Publishing Group Jul 2020
Copyright_xml – notice: Springer Nature Limited 2020
– notice: Copyright Nature Publishing Group Jul 2020
DBID AAYXX
CITATION
3V.
7RV
7X7
7XB
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
KB0
LK8
M0S
M7P
NAPCQ
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
DOI 10.1038/s42255-020-0244-3
DatabaseName CrossRef
ProQuest Central (Corporate)
Nursing & Allied Health Database
Health & Medical Collection (ProQuest)
ProQuest Central (purchase pre-March 2016)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central Database Suite (ProQuest)
Natural Science Collection
ProQuest One
ProQuest Central
Proquest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Collection (ProQuest)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Health & Medical Collection
Biological Science Database (ProQuest)
Nursing & Allied Health Premium
Proquest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle CrossRef
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList ProQuest Central Student
Database_xml – sequence: 1
  dbid: 7RV
  name: Nursing & Allied Health Database
  url: https://search.proquest.com/nahs
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
EISSN 2522-5812
EndPage 565
ExternalDocumentID 10_1038_s42255_020_0244_3
GroupedDBID 0R~
53G
AAEEF
AARCD
AAYZH
ABJNI
ACBWK
ADBBV
AFSHS
AIBTJ
ALFFA
ALMA_UNASSIGNED_HOLDINGS
EBS
EJD
FSGXE
NNMJJ
ODYON
RNT
SIXXV
SNYQT
SOJ
TBHMF
7RV
7X7
8FI
8FJ
AAYXX
ABUWG
AFANA
AFFHD
AFKRA
AGSTI
ATHPR
BBNVY
BENPR
BHPHI
CCPQU
CITATION
FYUFA
HCIFZ
HMCUK
M7P
NAPCQ
PHGZM
PHGZT
PPXIY
PQGLB
UKHRP
3V.
7XB
8FE
8FH
8FK
AZQEC
DWQXO
GNUQQ
K9.
LK8
PJZUB
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
7X8
ID FETCH-LOGICAL-c349t-9d59625873c7898da5375ed2a2279c48a74f2a5c06fd917e3cbe65988e4232fa3
IEDL.DBID 7RV
ISICitedReferencesCount 1
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000551962800003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2522-5812
IngestDate Thu Oct 02 21:27:35 EDT 2025
Tue Oct 07 07:30:56 EDT 2025
Sat Nov 29 06:12:56 EST 2025
Tue Nov 18 19:52:41 EST 2025
Fri Feb 21 02:38:35 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c349t-9d59625873c7898da5375ed2a2279c48a74f2a5c06fd917e3cbe65988e4232fa3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-6687-8495
PQID 3226088690
PQPubID 7343587
PageCount 2
ParticipantIDs proquest_miscellaneous_2426181181
proquest_journals_3226088690
crossref_citationtrail_10_1038_s42255_020_0244_3
crossref_primary_10_1038_s42255_020_0244_3
springer_journals_10_1038_s42255_020_0244_3
PublicationCentury 2000
PublicationDate 2020-07-01
PublicationDateYYYYMMDD 2020-07-01
PublicationDate_xml – month: 07
  year: 2020
  text: 2020-07-01
  day: 01
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Nature metabolism
PublicationTitleAbbrev Nat Metab
PublicationYear 2020
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References HangauerMJNature20175512472501:CAS:528:DC%2BC2sXhslehur3P10.1038/nature24297
CarlisleAENat. Metab.202010.1038/s42255-020-0224-7
LiouGYStorzPFree Radic. Res.2010444794961:CAS:528:DC%2BC3cXkvVyhu78%3D10.3109/10715761003667554
LockwoodWWPLoS Med.20107e100031510.1371/journal.pmed.1000315
YangWSCell20141563173311:CAS:528:DC%2BC2cXhtF2is70%3D10.1016/j.cell.2013.12.010
ZouYNat. Commun.20191010.1038/s41467-019-09277-9
DollSNature20195756936981:CAS:528:DC%2BC1MXitFGns7vN10.1038/s41586-019-1707-0
MiessHOncogene201837543554501:CAS:528:DC%2BC1cXhtVOksr3O10.1038/s41388-018-0315-z
SunNCRISPR J.201922302451:CAS:528:DC%2BC1MXhs1arsb7M10.1089/crispr.2019.0018
BersukerKNature20195756886921:CAS:528:DC%2BC1MXitFGns7vM10.1038/s41586-019-1705-2
GougeJCell2015163137513871:CAS:528:DC%2BC2MXhvFKksb%2FK10.1016/j.cell.2015.11.005
AmbrosoneCBJ. Clin. Oncol.20203880481410.1200/JCO.19.01203
CB Ambrosone (244_CR12) 2020; 38
MJ Hangauer (244_CR2) 2017; 551
AE Carlisle (244_CR3) 2020
K Bersuker (244_CR8) 2019; 575
GY Liou (244_CR1) 2010; 44
Y Zou (244_CR6) 2019; 10
WW Lockwood (244_CR11) 2010; 7
S Doll (244_CR9) 2019; 575
H Miess (244_CR5) 2018; 37
N Sun (244_CR7) 2019; 2
WS Yang (244_CR4) 2014; 156
J Gouge (244_CR10) 2015; 163
References_xml – reference: DollSNature20195756936981:CAS:528:DC%2BC1MXitFGns7vN10.1038/s41586-019-1707-0
– reference: AmbrosoneCBJ. Clin. Oncol.20203880481410.1200/JCO.19.01203
– reference: LiouGYStorzPFree Radic. Res.2010444794961:CAS:528:DC%2BC3cXkvVyhu78%3D10.3109/10715761003667554
– reference: BersukerKNature20195756886921:CAS:528:DC%2BC1MXitFGns7vM10.1038/s41586-019-1705-2
– reference: YangWSCell20141563173311:CAS:528:DC%2BC2cXhtF2is70%3D10.1016/j.cell.2013.12.010
– reference: CarlisleAENat. Metab.202010.1038/s42255-020-0224-7
– reference: LockwoodWWPLoS Med.20107e100031510.1371/journal.pmed.1000315
– reference: MiessHOncogene201837543554501:CAS:528:DC%2BC1cXhtVOksr3O10.1038/s41388-018-0315-z
– reference: GougeJCell2015163137513871:CAS:528:DC%2BC2MXhvFKksb%2FK10.1016/j.cell.2015.11.005
– reference: SunNCRISPR J.201922302451:CAS:528:DC%2BC1MXhs1arsb7M10.1089/crispr.2019.0018
– reference: HangauerMJNature20175512472501:CAS:528:DC%2BC2sXhslehur3P10.1038/nature24297
– reference: ZouYNat. Commun.20191010.1038/s41467-019-09277-9
– volume: 575
  start-page: 688
  year: 2019
  ident: 244_CR8
  publication-title: Nature
  doi: 10.1038/s41586-019-1705-2
– volume: 551
  start-page: 247
  year: 2017
  ident: 244_CR2
  publication-title: Nature
  doi: 10.1038/nature24297
– volume: 156
  start-page: 317
  year: 2014
  ident: 244_CR4
  publication-title: Cell
  doi: 10.1016/j.cell.2013.12.010
– volume: 2
  start-page: 230
  year: 2019
  ident: 244_CR7
  publication-title: CRISPR J.
  doi: 10.1089/crispr.2019.0018
– volume: 10
  year: 2019
  ident: 244_CR6
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09277-9
– volume: 44
  start-page: 479
  year: 2010
  ident: 244_CR1
  publication-title: Free Radic. Res.
  doi: 10.3109/10715761003667554
– volume: 7
  start-page: e1000315
  year: 2010
  ident: 244_CR11
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.1000315
– volume: 37
  start-page: 5435
  year: 2018
  ident: 244_CR5
  publication-title: Oncogene
  doi: 10.1038/s41388-018-0315-z
– volume: 163
  start-page: 1375
  year: 2015
  ident: 244_CR10
  publication-title: Cell
  doi: 10.1016/j.cell.2015.11.005
– volume: 575
  start-page: 693
  year: 2019
  ident: 244_CR9
  publication-title: Nature
  doi: 10.1038/s41586-019-1707-0
– volume: 38
  start-page: 804
  year: 2020
  ident: 244_CR12
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.19.01203
– year: 2020
  ident: 244_CR3
  publication-title: Nat. Metab.
  doi: 10.1038/s42255-020-0224-7
SSID ssj0002114129
Score 2.1179793
Snippet Selenium is a micronutrient essential for the generation of selenoproteins, which function predominantly by detoxifying cellular reactive oxygen species. In...
SourceID proquest
crossref
springer
SourceType Aggregation Database
Enrichment Source
Index Database
Publisher
StartPage 564
SubjectTerms 631/443/319
631/67/1059
631/67/1347
631/67/2327
Ablation
Biomarkers
Biomedical and Life Sciences
Breast cancer
Cell death
Cell viability
CRISPR
Ferroptosis
Genomes
Glutathione
Kinases
Life Sciences
Localization
Metabolism
Micronutrients
News & Views
news-and-views
Proteins
Reactive oxygen species
RNA polymerase
Selenide
Selenium
Selenocysteine
Selenoproteins
Transfer RNA
Title A micronutrient with major effects on cancer cell viability
URI https://link.springer.com/article/10.1038/s42255-020-0244-3
https://www.proquest.com/docview/3226088690
https://www.proquest.com/docview/2426181181
Volume 2
WOSCitedRecordID wos000551962800003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 2522-5812
  dateEnd: 20241211
  omitProxy: false
  ssIdentifier: ssj0002114129
  issn: 2522-5812
  databaseCode: M7P
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2522-5812
  dateEnd: 20241211
  omitProxy: false
  ssIdentifier: ssj0002114129
  issn: 2522-5812
  databaseCode: 7X7
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Nursing & Allied Health Database
  customDbUrl:
  eissn: 2522-5812
  dateEnd: 20241211
  omitProxy: false
  ssIdentifier: ssj0002114129
  issn: 2522-5812
  databaseCode: 7RV
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/nahs
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Proquest Central
  customDbUrl:
  eissn: 2522-5812
  dateEnd: 20241211
  omitProxy: false
  ssIdentifier: ssj0002114129
  issn: 2522-5812
  databaseCode: BENPR
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEB509eDFByqurksET0qwNsk2xYOoKB5kWURlbyFNU1C01e0q-O-d6ba7KOhFaHPpI-HrTObZGYB9qTIq7KV5ENmAS-81t3GiuEczDAWIS2zVDujhJur39XAYD2qHW1mnVTZ7YrVRp4UjH_kREl4POQKNudPXN05doyi6WrfQmIeFY9KNkZ6j24epjwWNG4nyrAlmCn1U4goU_ZIc4CklF9_F0UzH_BEWraTN1cp_17kKy7Weyc4mhLEGcz5fh5Mz9kIJeDmV4Edpw8gLy17sUzFidWIHK3LmiBJGjHz67ONxUsj7cwPury7vLq553T2BOyHjMY9TaqyjdCRcpGOdWiUi5dPQUs1AJ7WNZBZa5YJelqLN5oVLfE_FWnuK3WZWbEIrL3K_BUyRBKMIaYDWmpdOh2mSUeE_lWitwqQNQQOicXVpcepw8WyqELfQZoK7QdwN4W5EGw6mj7xO6mr8dXOnwdrULFaaGdBt2JteRuYgdGzui_fSkP6BKgwebThsvujsFb9OuP33hDuwFFYkRFm7HWiNR-9-Fxbdx_ixHHUrGqRxGFWj7sLC-WV_cNulxNLBF_795IQ
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LT9wwEB4BRYJLWwRVt6WtK8EFZBHF9tpRhRBqi0AsKw6A9uY6jiNRQUI3CxV_qr-xM3nsCqRy41ApOSWxHc_neXjGMwAbUuWU2MvwSLuIyxAMd0mqeEAzDAWIT11dDuhioIdDMxolp3PwpzsLQ2GVHU-sGXVWetoj30Hg9XFFoDG3d_OLU9Uo8q52JTQaWByH-99oslW7R9-QvptxfPD97Oshb6sKcC9kMuFJRgVnlNHCa5OYzCmhVchiR7n0vDROyzx2ykf9PENbJgifhr5KjAnk08ydwHbn4QXycU3Gnh7p6Z4OGlMS5WfnPBVmp8I_VnQEOsJbSi4eir-ZTvvIDVtLt4NX_9u8vIaXrR7N9hvgr8BcKFbhyz67pgDDgkoMoDRltMvMrt3PcszawBVWFswT0seMfBbs7rJJVH6_BufPMt43sFCURXgLTJGEJg9whNZokN7EWZpTYkOVGqPitAdRRzTr29TpVMHjytYufGFsQ2eLdLZEZyt6sDX95KbJG_LUy-sdbW3LQio7I2wPPk8f4-Kn2XFFKG8rS_oVqmh49WC7Q9CsiX92-O7pDj_B0uHZycAOjobH72E5ruFLEcrrsDAZ34YPsOjvJpfV-GONfwY_nhtYfwF4ZTuA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+micronutrient+with+major+effects+on+cancer+cell+viability&rft.jtitle=Nature+metabolism&rft.au=Kapara%2C+Anastasia&rft.au=Vannini%2C+Alessandro&rft.au=Peck%2C+Barrie&rft.date=2020-07-01&rft.issn=2522-5812&rft.eissn=2522-5812&rft.volume=2&rft.issue=7&rft.spage=564&rft_id=info:doi/10.1038%2Fs42255-020-0244-3&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2522-5812&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2522-5812&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2522-5812&client=summon