Cytological evaluation of biological prognostic markers from primary breast carcinomas
This study was undertaken to evaluate our ability to detect multiple molecular markers of prognosis and response to treatment in fine needle aspirates (FNA) from patients with primary breast carcinomas. 147 patients with operable primary breast carcinomas who had been recruited to a randomized trial...
Saved in:
| Published in: | Breast cancer research and treatment Vol. 44; no. 1; pp. 65 - 74 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Dordrecht
Springer
01.05.1997
Springer Nature B.V |
| Subjects: | |
| ISSN: | 0167-6806, 1573-7217 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | This study was undertaken to evaluate our ability to detect multiple molecular markers of prognosis and response to treatment in fine needle aspirates (FNA) from patients with primary breast carcinomas. 147 patients with operable primary breast carcinomas who had been recruited to a randomized trial of primary medical therapy (PMT) versus adjuvant chemoendocrine therapy were analysed. FNAs were taken prior to therapy and from this multiple slides were produced using cytospin cytocentrifugation and stored at -80 degrees C for subsequent immunocytochemical analysis (ICA). ICA was performed for oestrogen receptor (ER), progesterone receptor (PgR), p53, Ki67, and Bcl-2. Part of the aspirate was snap frozen and used for flow cytometric analysis of ploidy and S-phase fraction (SPF). In a subgroup of 50 patients who had surgery prior to systemic therapy, as well as FNAs, sections were also taken from paraffin-embedded blocks and stained by ICA for ER, PgR and p53 for validation. In these patients ER was additionally measured by enzyme immunoassay (EIA) from frozen tissue taken at surgery. ER, PgR, p53, Bcl-2, and Ki67 were successfully detected by ICA while ploidy and SPF were successfully measured by flow cytometry from FNA material. The percentage positive values obtained were reasonable and as follows: 74% for ER, 70% for PgR, 36% for p53, 80% for Bcl-2,68% of tumours were aneuploid and 32% diploid. Significant relationships between these measurements were observed in accordance with expectations. The concordance for ER, PgR, and p53 from FNA when compared to ICA of matching histological sections was 91.5%, 75.5%, and 75% respectively. For ER the concordance between measurement by ICA of cytological and histological samples and by EIA of frozen tissue was 82.5% and 84% respectively. These results indicate that multiple molecular markers can be adequately tested on cytological preparations from primary breast tumours. These markers can be used to determine prognosis and predict response to PMT. |
|---|---|
| AbstractList | This study was undertaken to evaluate our ability to detect multiple molecular markers of prognosis and response to treatment in fine needle aspirates (FNA) from patients with primary breast carcinomas. 147 patients with operable primary breast carcinomas who had been recruited to a randomized trial of primary medical therapy (PMT) versus adjuvant chemoendocrine therapy were analysed. FNAs were taken prior to therapy and from this multiple slides were produced using cytospin cytocentrifugation and stored at -80 degrees C for subsequent immunocytochemical analysis (ICA). ICA was performed for oestrogen receptor (ER), progesterone receptor (PgR), p53, Ki67, and Bcl-2. Part of the aspirate was snap frozen and used for flow cytometric analysis of ploidy and S-phase fraction (SPF). In a subgroup of 50 patients who had surgery prior to systemic therapy, as well as FNAs, sections were also taken from paraffin-embedded blocks and stained by ICA for ER, PgR and p53 for validation. In these patients ER was additionally measured by enzyme immunoassay (EIA) from frozen tissue taken at surgery. ER, PgR, p53, Bcl-2, and Ki67 were successfully detected by ICA while ploidy and SPF were successfully measured by flow cytometry from FNA material. The percentage positive values obtained were reasonable and as follows: 74% for ER, 70% for PgR, 36% for p53, 80% for Bcl-2,68% of tumours were aneuploid and 32% diploid. Significant relationships between these measurements were observed in accordance with expectations. The concordance for ER, PgR, and p53 from FNA when compared to ICA of matching histological sections was 91.5%, 75.5%, and 75% respectively. For ER the concordance between measurement by ICA of cytological and histological samples and by EIA of frozen tissue was 82.5% and 84% respectively. These results indicate that multiple molecular markers can be adequately tested on cytological preparations from primary breast tumours. These markers can be used to determine prognosis and predict response to PMT. This study was undertaken to evaluate our ability to detect multiple molecular markers of prognosis and response to treatment in fine needle aspirates (FNA) from patients with primary breast carcinomas. 147 patients with operable primary breast carcinomas who had been recruited to a randomized trial of primary medical therapy (PMT) versus adjuvant chemoendocrine therapy were analysed. FNAs were taken prior to therapy and from this multiple slides were produced using cytospin cytocentrifugation and stored at -80 degrees C for subsequent immunocytochemical analysis (ICA). ICA was performed for oestrogen receptor (ER), progesterone receptor (PgR), p53, Ki67, and Bcl-2. Part of the aspirate was snap frozen and used for flow cytometric analysis of ploidy and S-phase fraction (SPF). In a subgroup of 50 patients who had surgery prior to systemic therapy, as well as FNAs, sections were also taken from paraffin-embedded blocks and stained by ICA for ER, PgR and p53 for validation. In these patients ER was additionally measured by enzyme immunoassay (EIA) from frozen tissue taken at surgery. ER, PgR, p53, Bcl-2, and Ki67 were successfully detected by ICA while ploidy and SPF were successfully measured by flow cytometry from FNA material. The percentage positive values obtained were reasonable and as follows: 74% for ER, 70% for PgR, 36% for p53, 80% for Bcl-2,68% of tumours were aneuploid and 32% diploid. Significant relationships between these measurements were observed in accordance with expectations. The concordance for ER, PgR, and p53 from FNA when compared to ICA of matching histological sections was 91.5%, 75.5%, and 75% respectively. For ER the concordance between measurement by ICA of cytological and histological samples and by EIA of frozen tissue was 82.5% and 84% respectively. These results indicate that multiple molecular markers can be adequately tested on cytological preparations from primary breast tumours. These markers can be used to determine prognosis and predict response to PMT.This study was undertaken to evaluate our ability to detect multiple molecular markers of prognosis and response to treatment in fine needle aspirates (FNA) from patients with primary breast carcinomas. 147 patients with operable primary breast carcinomas who had been recruited to a randomized trial of primary medical therapy (PMT) versus adjuvant chemoendocrine therapy were analysed. FNAs were taken prior to therapy and from this multiple slides were produced using cytospin cytocentrifugation and stored at -80 degrees C for subsequent immunocytochemical analysis (ICA). ICA was performed for oestrogen receptor (ER), progesterone receptor (PgR), p53, Ki67, and Bcl-2. Part of the aspirate was snap frozen and used for flow cytometric analysis of ploidy and S-phase fraction (SPF). In a subgroup of 50 patients who had surgery prior to systemic therapy, as well as FNAs, sections were also taken from paraffin-embedded blocks and stained by ICA for ER, PgR and p53 for validation. In these patients ER was additionally measured by enzyme immunoassay (EIA) from frozen tissue taken at surgery. ER, PgR, p53, Bcl-2, and Ki67 were successfully detected by ICA while ploidy and SPF were successfully measured by flow cytometry from FNA material. The percentage positive values obtained were reasonable and as follows: 74% for ER, 70% for PgR, 36% for p53, 80% for Bcl-2,68% of tumours were aneuploid and 32% diploid. Significant relationships between these measurements were observed in accordance with expectations. The concordance for ER, PgR, and p53 from FNA when compared to ICA of matching histological sections was 91.5%, 75.5%, and 75% respectively. For ER the concordance between measurement by ICA of cytological and histological samples and by EIA of frozen tissue was 82.5% and 84% respectively. These results indicate that multiple molecular markers can be adequately tested on cytological preparations from primary breast tumours. These markers can be used to determine prognosis and predict response to PMT. This study was undertaken to evaluate our abilityto detect multiple molecular markers of prognosis andresponse to treatment in fine needle aspirates (FNA)from patients with primary breast carcinomas. 147 patientswith operable primary breast carcinomas who had beenrecruited to a randomized trial of primary medicaltherapy (PMT) versus adjuvant chemoendocrine therapy were analysed.FNAs were taken prior to therapy and fromthis multiple slides were produced using cytospin cytocentrifugationand stored at - 80 °C for subsequentimmunocytochemical analysis (ICA). ICA was performed for oestrogenreceptor (ER), progesterone receptor (PgR), p53, Ki67, andBcl-2. Part of the aspirate was snap frozenand used for flow cytometric analysis of ploidyand S-phase fraction (SPF). In a subgroup of50 patients who had surgery prior to systemictherapy, as well as FNAs, sections were alsotaken from paraffin-embedded blocks and stained by ICAfor ER, PgR and p53 for validation. Inthese patients ER was additionally measured by enzymeimmunoassay (EIA) from frozen tissue taken at surgery.ER, PgR, p53, Bcl-2, and Ki67 were successfullydetected by ICA while ploidy and SPF weresuccessfully measured by flow cytometry from FNA material.The percentage positive values obtained were reasonable andas follows: 74% for ER, 70% for PgR,36% for p53, 80% for Bcl-2. 68% oftumours were aneuploid and 32% diploid. Significant relationshipsbetween these measurements were observed in accordance withexpectations. The concordance for ER, PgR, and p53from FNA when compared to ICA of matchinghistological sections was 91.5%, 75.5%, and 75% respectively.For ER the concordance between measurement by ICAof cytological and histological samples and by EIAof frozen tissue was 82.5% and 84% respectively.These results indicate that multiple molecular markers canbe adequately tested on cytological preparations from primarybreast tumours. These markers can be used todetermine prognosis and predict response to PMT.[PUBLICATION ABSTRACT] |
| Author | Allred, D.C. Ashley, S.E. Osborne, C.K. Trott, P.A. Ormerod, M.G. Titley, J.C. Powles, T.J. Makris, A. Fernando, I.N. Dowsett, M. |
| Author_xml | – sequence: 1 givenname: A. surname: Makris fullname: Makris, A. – sequence: 2 givenname: D.C. surname: Allred fullname: Allred, D.C. – sequence: 3 givenname: T.J. surname: Powles fullname: Powles, T.J. – sequence: 4 givenname: M. surname: Dowsett fullname: Dowsett, M. – sequence: 5 givenname: I.N. surname: Fernando fullname: Fernando, I.N. – sequence: 6 givenname: P.A. surname: Trott fullname: Trott, P.A. – sequence: 7 givenname: S.E. surname: Ashley fullname: Ashley, S.E. – sequence: 8 givenname: M.G. surname: Ormerod fullname: Ormerod, M.G. – sequence: 9 givenname: J.C. surname: Titley fullname: Titley, J.C. – sequence: 10 givenname: C.K. surname: Osborne fullname: Osborne, C.K. |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2695388$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/9164679$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kc1LwzAYxoMoc5uePQkFxVtd0nw13sbwCwZe1GtJ03RktokmrbD_3syVgQNzCcnze_K-ed4JOLbOagAuELxFMMOz-R2CkHLERUY4Q0dgjCjHKc8QPwZjiBhPWQ7ZKZiEsIYQCg7FCIwEYoRxMQbvi03nGrcySjaJ_pZNLzvjbOLqpDR74dO7lXWhMypppf_QPiS1d228N_G8SUqvZegSJb0y1rUynIGTWjZBnw_7FLw93L8untLly-PzYr5MFSaiS3OGcK6FUrzMWamIFChjRPAK1rkgUqGMV0KXvKZxVQorzCqVkUoTDWVJKZ6Cm927scOvXoeuaE1Qummk1a4PBRcQIUrzCF4dgGvXext7K2KOHBHCchKpy4Hqy1ZXxfC_Yogr6teDLkPMpfbSKhP2WMYExfm22GyHKe9C8LreEwhuy-FiXvwZW3TQA4cy3e8kOi9N86_vB5X0moI |
| CODEN | BCTRD6 |
| CitedBy_id | crossref_primary_10_1038_modpathol_3880216 crossref_primary_10_1002_mc_22164 crossref_primary_10_1073_pnas_0408273101 crossref_primary_10_1002__SICI_1097_0142_19990825_87_4_224__AID_CNCR10_3_0_CO_2_5 crossref_primary_10_1016_S0888_7543_02_00021_6 crossref_primary_10_1002_1097_0320_20001101_41_3_166__AID_CYTO2_3_0_CO_2_Y crossref_primary_10_1093_jnci_92_15_1217 crossref_primary_10_1016_S0169_5002_00_00095_7 crossref_primary_10_1002_jbt_20281 crossref_primary_10_1002_cncr_9031 crossref_primary_10_1002_dc_10257 crossref_primary_10_1080_02841860410033721 crossref_primary_10_1054_cdip_2001_0086 crossref_primary_10_1093_carcin_bgi278 crossref_primary_10_1002_dc_21313 crossref_primary_10_1177_172460080301800403 crossref_primary_10_1200_JCO_2000_18_7_1558 crossref_primary_10_1023_A_1006179511178 crossref_primary_10_1002_dc_20007 crossref_primary_10_1016_j_suronc_2007_03_004 crossref_primary_10_1038_modpathol_3880149 crossref_primary_10_1177_172460080201700103 crossref_primary_10_1186_1471_2407_14_895 crossref_primary_10_1371_journal_pone_0025125 crossref_primary_10_1016_j_clon_2012_04_005 crossref_primary_10_1097_PAI_0b013e318234aa12 crossref_primary_10_1023_A_1007054210133 crossref_primary_10_1002_dc_10348 crossref_primary_10_1016_j_taap_2008_06_007 crossref_primary_10_1007_BF02968296 crossref_primary_10_1093_annonc_mdi150 crossref_primary_10_1186_s12913_020_05752_y crossref_primary_10_1002_dc_24311 crossref_primary_10_1002_cncr_11188 crossref_primary_10_1002__SICI_1097_0142_20000225_90_1_61__AID_CNCR9_3_0_CO_2_N |
| Cites_doi | 10.1016/S0140-6736(94)90447-2 10.1002/1097-0142(19931215)72:12<3641::AID-CNCR2820721215>3.0.CO;2-8 10.1002/dc.2840060205 10.1093/jnci/83.3.154 10.3109/02841868809090312 10.1002/1097-0142(19930901)72:5<1499::AID-CNCR2820720502>3.0.CO;2-# 10.1002/1097-0142(19880201)61:3<420::AID-CNCR2820610303>3.0.CO;2-0 10.1001/archsurg.1990.01410130113018 10.1093/jnci/82.12.1006 10.1002/1097-0142(19900501)65:9+<2121::AID-CNCR2820651408>3.0.CO;2-M 10.1093/jnci/86.7.499 10.1136/jcp.42.7.733 10.1016/0960-9776(93)90034-D 10.1093/jnci/85.3.200 10.1200/JCO.1990.8.12.2040 10.1093/ajcp/88.4.399 10.1002/ijc.2910590508 10.1007/BF00665773 10.1007/BF01806305 10.1002/1097-0142(19910801)68:3<549::AID-CNCR2820680318>3.0.CO;2-J 10.1007/BF00665800 10.1007/BF00192638 10.1007/BF00682725 10.1007/BF00400963 10.1126/science.7973635 10.1056/NEJM198903093201003 10.1038/bjc.1988.60 10.1002/1097-0142(19910115)67:2<421::AID-CNCR2820670217>3.0.CO;2-Q 10.1200/JCO.1995.13.3.547 10.1007/BF00666204 10.1038/bjc.1989.256 10.1056/NEJM198902233200811 10.1111/j.1365-2303.1991.tb00378.x 10.1200/JCO.1988.6.7.1076 10.1093/ajcp/94.6.681 10.1016/S0140-6736(94)90066-3 10.1007/BF02235749 10.1002/1097-0142(197910)44:4<1458::AID-CNCR2820440440>3.0.CO;2-T 10.1111/j.1365-2303.1992.tb00041.x 10.1093/jnci/85.12.965 10.1038/bjc.1990.239 10.1038/bjc.1996.111 10.1002/ijc.2910570610 10.1002/bjs.1800791224 10.1002/dc.2840100302 10.1016/0960-9776(92)90143-P 10.1007/BF00683198 10.1200/JCO.1986.4.4.459 10.1002/1097-0142(19900301)65:5<1180::AID-CNCR2820650525>3.0.CO;2-7 10.1002/1097-0142(19930901)72:5<1642::AID-CNCR2820720525>3.0.CO;2-8 10.1016/S0959-8049(05)80124-8 10.1093/ajcp/96.5.654 10.1016/S0140-6736(87)91071-3 |
| ContentType | Journal Article |
| Copyright | 1997 INIST-CNRS Kluwer Academic Publishers 1997 |
| Copyright_xml | – notice: 1997 INIST-CNRS – notice: Kluwer Academic Publishers 1997 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7TO 7X7 7XB 88E 8AO 8C1 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH H94 K9- K9. M0R M0S M1P M2O MBDVC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U 7X8 |
| DOI | 10.1023/A:1005717924761 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database (Proquest) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts Consumer Health Database ProQuest Health & Medical Complete (Alumni) Consumer Health Database ProQuest Health & Medical Collection Medical Database Research Library Research Library (Corporate) ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Pharma Collection ProQuest Family Health (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest Central Basic ProQuest Family Health ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Research Library Prep |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1573-7217 |
| EndPage | 74 |
| ExternalDocumentID | 2716473761 9164679 2695388 10_1023_A_1005717924761 |
| Genre | Research Support, U.S. Gov't, P.H.S Comparative Study Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: CA30195 – fundername: NCI NIH HHS grantid: P30-CA 54174 |
| GroupedDBID | --- -XW -Y2 -~C .86 .GJ .VR 06C 06D 0R~ 0VY 199 1N0 1SB 2.D 203 23N 28- 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3O- 4.4 406 408 409 40D 40E 53G 5GY 5QI 5VS 67Z 6NX 78A 7X7 88E 8AO 8C1 8FI 8FJ 8G5 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AAPKM AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYXX ABAKF ABBBX ABBRH ABBXA ABDBE ABDZT ABECU ABFSG ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKCH ABKTR ABLJU ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABRTQ ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACHSB ACHVE ACHXU ACIHN ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACSTC ACUDM ACZOJ ADBBV ADHHG ADHIR ADHKG ADIMF ADJJI ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEAQA AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AETLH AEVLU AEXYK AEZWR AFBBN AFDYV AFDZB AFEXP AFFHD AFFNX AFHIU AFJLC AFKRA AFLOW AFOHR AFQWF AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGQPQ AGRTI AGVAE AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHMBA AHPBZ AHSBF AHWEU AHYZX AIAKS AIGIU AIIXL AILAN AITGF AIXLP AJBLW AJRNO AJZVZ AKMHD ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG ATHPR AVWKF AXYYD AYFIA AZFZN AZQEC B-. BA0 BBWZM BDATZ BENPR BGNMA BKNYI BPHCQ BSONS BVXVI CAG CCPQU CITATION COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 DWQXO EBD EBLON EBS EIOEI EJD EMB EMOBN EN4 ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ7 GQ8 GRRUI GUQSH GXS H13 HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IAO ICW IHE IHR IHW IJ- IKXTQ IMOTQ INH INR ITC ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ K9- KDC KOV KOW KPH LAK LLZTM M0R M1P M2O M4Y MA- N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P P9S PF0 PHGZM PHGZT PJZUB PPXIY PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S37 S3B SAP SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TEORI TSG TSK TSV TT1 TUC U2A U9L UDS UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK8 YLTOR Z45 ZGI ZMTXR ZOVNA ZXP ~EX ~KM AAYZH AESKC ALIPV IQODW -53 -5E -5G -BR -EM 3V. ADINQ CGR CUY CVF ECM EIF GQ6 NPM Z7U Z7W Z81 Z82 Z83 Z87 Z8O Z8Q Z8U Z8V Z8W Z91 7TO 7XB 8FK H94 K9. MBDVC PKEHL PQEST PQUKI PRINS Q9U 7X8 |
| ID | FETCH-LOGICAL-c349t-86138e9cc7b86bc4a9126497d0f894ac127d9eb7f5555dc3c36dc24de4e0ab553 |
| IEDL.DBID | BENPR |
| ISICitedReferencesCount | 49 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=10_1023_A_1005717924761&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0167-6806 |
| IngestDate | Sun Nov 09 09:19:44 EST 2025 Sat Nov 08 16:14:26 EST 2025 Wed Feb 19 02:36:12 EST 2025 Mon Jul 21 09:15:38 EDT 2025 Sat Nov 29 07:49:35 EST 2025 Tue Nov 18 22:27:59 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Human Carcinoma Prognosis Conservation Estrogen Biological marker Malignant tumor Aspiration punction Mammary gland diseases Randomization TP53 Gene Fine needle Mammary gland Progesterone Onc gene Tumor suppressor gene Hormonal receptor |
| Language | English |
| License | https://www.springernature.com/gp/researchers/text-and-data-mining CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c349t-86138e9cc7b86bc4a9126497d0f894ac127d9eb7f5555dc3c36dc24de4e0ab553 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 content type line 23 ObjectType-Undefined-3 |
| PMID | 9164679 |
| PQID | 1027144684 |
| PQPubID | 36266 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_79011558 proquest_journals_1027144684 pubmed_primary_9164679 pascalfrancis_primary_2695388 crossref_primary_10_1023_A_1005717924761 crossref_citationtrail_10_1023_A_1005717924761 |
| PublicationCentury | 1900 |
| PublicationDate | 1997-05-01 |
| PublicationDateYYYYMMDD | 1997-05-01 |
| PublicationDate_xml | – month: 05 year: 1997 text: 1997-05-01 day: 01 |
| PublicationDecade | 1990 |
| PublicationPlace | Dordrecht |
| PublicationPlace_xml | – name: Dordrecht – name: Netherlands |
| PublicationTitle | Breast cancer research and treatment |
| PublicationTitleAlternate | Breast Cancer Res Treat |
| PublicationYear | 1997 |
| Publisher | Springer Springer Nature B.V |
| Publisher_xml | – name: Springer – name: Springer Nature B.V |
| References | RA Walker (125881_CR56) 1988; 57 WL McGuire (125881_CR50) 1989; 320 G Gasparini (125881_CR21) 1992; 1 A Marrazzo (125881_CR42) 1993; 13 H Helin (125881_CR45) 1990; 62 DC Allred (125881_CR15) 1993; 27 MG Ormerod (125881_CR30) 1994 DC Allred (125881_CR10) 1993; 85 B Hsu (125881_CR24) 1994; 46 G Gasparini (125881_CR55) 1989; 14 SM O'Reilly (125881_CR16) 1990; 8 J Lamb (125881_CR61) 1989; 42 WL McGuire (125881_CR48) 1983; 10 JJ Isola (125881_CR57) 1990; 65 KJ Walker (125881_CR28) 1988; 48 CT Curtin (125881_CR41) 1982; 26 LG Koss (125881_CR2) 1993; 72 DC Allred (125881_CR29) 1990; 125 WL McGuire (125881_CR51) 1990; 82 LG Dressler (125881_CR18) 1988; 61 KR Lee (125881_CR60) 1987; 31 DJ Dabbs (125881_CR64) 1994; 10 M Helle (125881_CR37) 1989; 115 B Fisher (125881_CR49) 1986; 4 A Reiner (125881_CR47) 1987; 88 H Wintzer (125881_CR20) 1991; 67 B Frigo (125881_CR31) 1995; 33 RM Elledge (125881_CR38) 1993; 26 SRD Johnston (125881_CR53) 1995; 30A TS Kline (125881_CR1) 1979; 44 RC Coombes (125881_CR34) 1987; ii WL McGuire (125881_CR5) 1991; 83 SW Lowe (125881_CR13) 1994; 266 CM Ryde (125881_CR46) 1992; 3 B Fisher (125881_CR6) 1988; 6 A Marrazzo (125881_CR39) 1995; 15 TJ Powles (125881_CR27) 1995; 13 TJ Powles (125881_CR4) 1991; 2 R Silvestrini (125881_CR11) 1993; 85 L Skoog (125881_CR32) 1990; 6 G Burton (125881_CR33) 1985; 6 P Viehl (125881_CR54) 1990; 94 R Silvestrini (125881_CR25) 1994; 86 WL McGuire (125881_CR9) 1980 SM O'Reilly (125881_CR23) 1992; 28 R Nizzoli (125881_CR40) 1994; 38 O Gottardi (125881_CR19) 1993; 208 V Cavailles (125881_CR43) 1987; 79 CS Abendroth (125881_CR62) 1991; 96 SC Low (125881_CR8) 1992; 79 J Hurlimann (125881_CR26) 1995; 426 GM Clark (125881_CR17) 1989; 320 SM Thorpe (125881_CR36) 1988; 27 ER Fisher (125881_CR65) 1990; 65 RM Elledge (125881_CR35) 1994; 32 EDC Anderson (125881_CR7) 1989; 60 OR Koechli (125881_CR14) 1994; 344 AA Sahin (125881_CR22) 1991; 68 JMW Gee (125881_CR52) 1994; 59 G Gasparini (125881_CR58) 1994; 57 C Bozzetti (125881_CR44) 1994; 32 K Friedrichs (125881_CR12) 1993; 72 IA Robinson (125881_CR63) 1994; 343 LJ Layfield (125881_CR3) 1993; 72 PA Ellis (125881_CR59) 1996; 73 |
| References_xml | – volume: 344 start-page: 1647 year: 1994 ident: 125881_CR14 publication-title: Lancet doi: 10.1016/S0140-6736(94)90447-2 – volume: 72 start-page: 3641 year: 1993 ident: 125881_CR12 publication-title: Cancer doi: 10.1002/1097-0142(19931215)72:12<3641::AID-CNCR2820721215>3.0.CO;2-8 – volume: 6 start-page: 95 year: 1990 ident: 125881_CR32 publication-title: Diagn Cytopathol doi: 10.1002/dc.2840060205 – volume: 83 start-page: 154 year: 1991 ident: 125881_CR5 publication-title: JNCI doi: 10.1093/jnci/83.3.154 – volume: 27 start-page: 1 year: 1988 ident: 125881_CR36 publication-title: Acta Oncologica doi: 10.3109/02841868809090312 – volume: 72 start-page: 1499 year: 1993 ident: 125881_CR2 publication-title: Cancer doi: 10.1002/1097-0142(19930901)72:5<1499::AID-CNCR2820720502>3.0.CO;2-# – volume: 15 start-page: 521 year: 1995 ident: 125881_CR39 publication-title: Anticancer Research – volume: 61 start-page: 420 year: 1988 ident: 125881_CR18 publication-title: Cancer doi: 10.1002/1097-0142(19880201)61:3<420::AID-CNCR2820610303>3.0.CO;2-0 – volume: 125 start-page: 107 year: 1990 ident: 125881_CR29 publication-title: Arch Surg doi: 10.1001/archsurg.1990.01410130113018 – volume: 82 start-page: 1006 year: 1990 ident: 125881_CR51 publication-title: JNCI doi: 10.1093/jnci/82.12.1006 – volume: 65 start-page: 2121 year: 1990 ident: 125881_CR65 publication-title: Cancer doi: 10.1002/1097-0142(19900501)65:9+<2121::AID-CNCR2820651408>3.0.CO;2-M – volume: 46 start-page: 125 year: 1994 ident: 125881_CR24 publication-title: Cancer Bull – volume: 86 start-page: 499 year: 1994 ident: 125881_CR25 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/86.7.499 – volume: 42 start-page: 733 year: 1989 ident: 125881_CR61 publication-title: J Clin Pathol doi: 10.1136/jcp.42.7.733 – volume: 208 start-page: 33 year: 1993 ident: 125881_CR19 publication-title: Breast doi: 10.1016/0960-9776(93)90034-D – volume: 85 start-page: 200 year: 1993 ident: 125881_CR10 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/85.3.200 – volume: 8 start-page: 2040 year: 1990 ident: 125881_CR16 publication-title: J Clin Oncol doi: 10.1200/JCO.1990.8.12.2040 – volume: 88 start-page: 399 year: 1987 ident: 125881_CR47 publication-title: Am J Clin Pathol doi: 10.1093/ajcp/88.4.399 – volume: 59 start-page: 619 year: 1994 ident: 125881_CR52 publication-title: Int J Cancer doi: 10.1002/ijc.2910590508 – volume: 32 start-page: 221 year: 1994 ident: 125881_CR44 publication-title: Breast Cancer Res Treat doi: 10.1007/BF00665773 – volume: 14 start-page: 329 year: 1989 ident: 125881_CR55 publication-title: Breast Cancer Res Treat doi: 10.1007/BF01806305 – start-page: 39 volume-title: Breast cancer: experimental and clinical aspects year: 1980 ident: 125881_CR9 – volume: 68 start-page: 549 year: 1991 ident: 125881_CR22 publication-title: Cancer doi: 10.1002/1097-0142(19910801)68:3<549::AID-CNCR2820680318>3.0.CO;2-J – volume: 26 start-page: 225 year: 1993 ident: 125881_CR38 publication-title: Breast Cancer Res Treat doi: 10.1007/BF00665800 – volume: 79 start-page: 245 year: 1987 ident: 125881_CR43 publication-title: JNCI – volume: 31 start-page: 281 year: 1987 ident: 125881_CR60 publication-title: Acta Cytol – volume: 426 start-page: 163 year: 1995 ident: 125881_CR26 publication-title: Virchows Archiv doi: 10.1007/BF00192638 – volume: 33 start-page: 179 year: 1995 ident: 125881_CR31 publication-title: Breast Cancer Res Treat doi: 10.1007/BF00682725 – volume: 115 start-page: 361 year: 1989 ident: 125881_CR37 publication-title: J Cancer Res Clin Oncol doi: 10.1007/BF00400963 – volume: 266 start-page: 807 year: 1994 ident: 125881_CR13 publication-title: Science doi: 10.1126/science.7973635 – volume: 320 start-page: 627 year: 1989 ident: 125881_CR17 publication-title: N Engl J Med doi: 10.1056/NEJM198903093201003 – volume: 57 start-page: 281 year: 1988 ident: 125881_CR56 publication-title: Br J Cancer doi: 10.1038/bjc.1988.60 – volume: 67 start-page: 421 year: 1991 ident: 125881_CR20 publication-title: Cancer doi: 10.1002/1097-0142(19910115)67:2<421::AID-CNCR2820670217>3.0.CO;2-Q – volume: 13 start-page: 547 year: 1995 ident: 125881_CR27 publication-title: J Clin Oncol doi: 10.1200/JCO.1995.13.3.547 – volume: 32 start-page: 39 year: 1994 ident: 125881_CR35 publication-title: Breast Cancer Res Treat doi: 10.1007/BF00666204 – volume: 60 start-page: 223 year: 1989 ident: 125881_CR7 publication-title: Br J Cancer doi: 10.1038/bjc.1989.256 – volume: 320 start-page: 525 year: 1989 ident: 125881_CR50 publication-title: N Engl J Med doi: 10.1056/NEJM198902233200811 – volume: 2 start-page: 7 year: 1991 ident: 125881_CR4 publication-title: Cytopathology doi: 10.1111/j.1365-2303.1991.tb00378.x – volume: 6 start-page: 1076 year: 1988 ident: 125881_CR6 publication-title: J Clin Oncol doi: 10.1200/JCO.1988.6.7.1076 – volume: 94 start-page: 681 year: 1990 ident: 125881_CR54 publication-title: Am J Clin Pathol doi: 10.1093/ajcp/94.6.681 – volume: 343 start-page: 947 year: 1994 ident: 125881_CR63 publication-title: Lancet doi: 10.1016/S0140-6736(94)90066-3 – volume: 6 start-page: 164 year: 1985 ident: 125881_CR33 publication-title: Breast Cancer Res Treat doi: 10.1007/BF02235749 – volume: 38 start-page: 933 year: 1994 ident: 125881_CR40 publication-title: Acta Cytol – volume: 48 start-page: 6517 year: 1988 ident: 125881_CR28 publication-title: Cancer Res – volume: 44 start-page: 1458 year: 1979 ident: 125881_CR1 publication-title: Cancer doi: 10.1002/1097-0142(197910)44:4<1458::AID-CNCR2820440440>3.0.CO;2-T – volume-title: Flow cytometry. A practical approach year: 1994 ident: 125881_CR30 – volume: 3 start-page: 155 year: 1992 ident: 125881_CR46 publication-title: Cytopathology doi: 10.1111/j.1365-2303.1992.tb00041.x – volume: 85 start-page: 965 year: 1993 ident: 125881_CR11 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/85.12.965 – volume: 62 start-page: 109 year: 1990 ident: 125881_CR45 publication-title: Br J Cancer doi: 10.1038/bjc.1990.239 – volume: 73 start-page: 640 year: 1996 ident: 125881_CR59 publication-title: Br J Cancer doi: 10.1038/bjc.1996.111 – volume: 57 start-page: 822 year: 1994 ident: 125881_CR58 publication-title: Int J Cancer doi: 10.1002/ijc.2910570610 – volume: 79 start-page: 1314 year: 1992 ident: 125881_CR8 publication-title: Br J Surg doi: 10.1002/bjs.1800791224 – volume: 13 start-page: 2435 year: 1993 ident: 125881_CR42 publication-title: Anticancer Research – volume: 10 start-page: 203 year: 1994 ident: 125881_CR64 publication-title: Diagn Cytopathol doi: 10.1002/dc.2840100302 – volume: 26 start-page: 841 year: 1982 ident: 125881_CR41 publication-title: Acta Cytol – volume: 30A start-page: 1663 year: 1995 ident: 125881_CR53 publication-title: Eur J Cancer – volume: 1 start-page: 92 year: 1992 ident: 125881_CR21 publication-title: Breast doi: 10.1016/0960-9776(92)90143-P – volume: 27 start-page: 131 year: 1993 ident: 125881_CR15 publication-title: Breast Cancer Res Treat doi: 10.1007/BF00683198 – volume: 4 start-page: 459 year: 1986 ident: 125881_CR49 publication-title: J Clin Oncol doi: 10.1200/JCO.1986.4.4.459 – volume: 65 start-page: 1180 year: 1990 ident: 125881_CR57 publication-title: Cancer doi: 10.1002/1097-0142(19900301)65:5<1180::AID-CNCR2820650525>3.0.CO;2-7 – volume: 72 start-page: 1642 year: 1993 ident: 125881_CR3 publication-title: Cancer doi: 10.1002/1097-0142(19930901)72:5<1642::AID-CNCR2820720525>3.0.CO;2-8 – volume: 28 start-page: 681 year: 1992 ident: 125881_CR23 publication-title: Eur J Cancer doi: 10.1016/S0959-8049(05)80124-8 – volume: 10 start-page: 2 year: 1983 ident: 125881_CR48 publication-title: Semin Oncol – volume: 96 start-page: 654 year: 1991 ident: 125881_CR62 publication-title: Am J Clin Pathol doi: 10.1093/ajcp/96.5.654 – volume: ii start-page: 701 year: 1987 ident: 125881_CR34 publication-title: Lancet doi: 10.1016/S0140-6736(87)91071-3 |
| SSID | ssj0009709 |
| Score | 1.7277757 |
| Snippet | This study was undertaken to evaluate our ability to detect multiple molecular markers of prognosis and response to treatment in fine needle aspirates (FNA)... This study was undertaken to evaluate our abilityto detect multiple molecular markers of prognosis andresponse to treatment in fine needle aspirates (FNA)from... |
| SourceID | proquest pubmed pascalfrancis crossref |
| SourceType | Aggregation Database Index Database Enrichment Source |
| StartPage | 65 |
| SubjectTerms | Adult Aged Analysis of Variance Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Biopsy, Needle - methods Biopsy, Needle - standards Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - diagnosis Cancer research Centrifugation Cytodiagnosis - methods Cytodiagnosis - standards Female Flow Cytometry - methods Flow Cytometry - standards Genetics Gynecology. Andrology. Obstetrics Humans Immunoenzyme Techniques - standards Immunohistochemistry Ki-67 Antigen - analysis Mammary gland diseases Medical sciences Middle Aged Prognosis Proto-Oncogene Proteins c-bcl-2 - analysis Receptors, Estrogen - analysis Receptors, Estrogen - metabolism Receptors, Progesterone - analysis Receptors, Progesterone - metabolism Tumor Suppressor Protein p53 - analysis Tumors |
| Title | Cytological evaluation of biological prognostic markers from primary breast carcinomas |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/9164679 https://www.proquest.com/docview/1027144684 https://www.proquest.com/docview/79011558 |
| Volume | 44 |
| WOSCitedRecordID | wos10_1023_A_1005717924761&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Consumer Health Database customDbUrl: eissn: 1573-7217 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0009709 issn: 0167-6806 databaseCode: M0R dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1573-7217 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0009709 issn: 0167-6806 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1573-7217 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0009709 issn: 0167-6806 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1573-7217 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0009709 issn: 0167-6806 databaseCode: 8C1 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1573-7217 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0009709 issn: 0167-6806 databaseCode: M2O dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1573-7217 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0009709 issn: 0167-6806 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB6VBSEkRFseYilQH3rgEpQ4TmyfEF2BuLBFVVvtLYodR0Jqk2UTkPj3zCTeXW0luJCDpcSOlXhmPGPP-BuAb6gzwzxyUWCVMoFAHRsYjYKnuYsIJxa1Tp9sQo7HajLRd37DrfFhlfM5sZuoi9rSHjlKN5e0dlHiYvoQUNYo8q76FBprsE5IZWIA69-vxnc_l7C7sg_yIHTvVIXpf-A-aKwgQ3Ih02hFL21P8waHqOxzW7xufHZK6Prjez__E-x485Nd9vzyGT64ahc2b72DfQ_-jJ7b-XTIlkjgrC5ZD9fUVVBQV1UTwjP7R-E9s4bRMRV83kFXMEOR7i2zlKeoogCkffh9ffVrdBP41AuBjYVuA4VaXjltrTQqNVbkOkLLScsiLJUWuY24LLQzskzwKmxs47SwXBROuDA3SRIfwKCqK3cIzKShdtImuTUceaFUxpQFpQK0OS2m5BDO5wOfWY9LTukx_madf5zH2WW2QqkhnC1e8P_1etOTFUou2vNU40yvhnA8p1bmZbfJlqQawtdFNUoduVLyytWPTSbpxG6SYAcHPT8setYE2Cb10ds9f4GtHgeXIiePYdDOHt0JbNin9r6ZncKanMiuVFiqUXTq-RrvbsOu5D9eAKhv_Qs |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1da9swFL2EbGyFse_SbOmqhw324mIrtiU9jBGyhZQ2YQ_p6JtryTIMNruNnY78qf3G3euPhBSytzzMj5YtkHV0r2QdnQPwHnOmG3vWc4yU2vExxzpa4cBT3HqkE4tZpzabELOZvLpS3zrwpz0LQ7TKNiZWgTrJDf0jx9HNBa1dpP_55tYh1yjaXW0tNGpYnNvVb1yyFZ_OvmD_fuB8_HU-mjiNq4BjBr4qHYkJTFpljNAy1MaPlYeTAiUSN5XKj43HRaKsFmmAV2IGZhAmhvuJ9a0b64BcIjDkPyAlO1rsydGGUqJETSkhLfFQuuE9KSGcGiH88bXQ28qCT27iAjskrZ00dk91q5Q3fva_fazn8LSZXLNhPRpeQMdmL-HRtKEPvILvo1XZBnu20TlnecpqMaqqgChrWU761ewXkZcWBaNDOHi_EuZgmnj8JTPkwpQRveo1XO6lVYfQzfLMHgHToausMEFsNEekp1LrNCGjQxPTUlH04LTt6Mg0qutk_vEzqnb_-SAaRlvI6MHH9QtNu3Y_eryFnPXzPFSYx2QP-i06oiYyFdEGGj04WRdjTKGNojiz-bKIBJ1HDgKs4LDG37pmRXJ0Qr35d80n8Hgyn15EF2ez87dwUCv-Eke0D91ysbTH8NDclT-Kxbtq_DC43jcG_wKbWlR5 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1NT9wwEB0hqFAlBC3tiuXThyJxSZs4H7YPCKGFVRHtigMgbmnsOBJSm8AmgPhr_Dpm8rGrRYIbh-aYOJYSv5mxk-f3AL5hzXQTz3qOkVI7AdZYRysMPMWtRzqxWHUaswkxGsmrK3U2B0_dXhiiVXY5sU7UaWHoGzlGNxe0dpHBj6ylRZwdDQ9ubh1ykKI_rZ2dRgORU_v4gMu3cv_kCMd6l_Ph8fngp9M6DDjGD1TlSCxm0ipjhJaRNkGiPJwgKJG6mVRBYjwuUmW1yEI8UuMbP0oND1IbWDfRITlGYPpfED6imHapD6b0EiUaegnpikfSjV7ICuE0CUOBByLyZiri0k1S4uBkjavG69PeuvwNV_7nF_cJlttJNztsouQzzNl8FRZ_t7SCL3A5eKy6IsCm-uesyFgjUlVfICpbXpCuNftHpKZxyWhzDp6vBTuYJn5_xQy5M-VEu_oKF-_yVD2Yz4vcrgHTkausMGFiNMcIyKTWWUoGiCahJaTow_du0GPTqrGTKcjfuGYFcD8-jGdQ0oe9yQ3tc73edGsGRZP2PFJY32QfNjukxG3GKuMpTPqwM7mMuYZ-ICW5Le7KWNA-5TDEDnoNFic9K5KpE2r97Z53YBGhF_86GZ1uwMdGCJioo5swX43v7BZ8MPfVdTnerkOJwZ_3huAz_qRdPg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cytological+evaluation+of+biological+prognostic+markers+from+primary+breast+carcinomas&rft.jtitle=Breast+cancer+research+and+treatment&rft.au=Makris%2C+A&rft.au=Allred%2C+D+C&rft.au=Powles%2C+T+J&rft.au=Dowsett%2C+M&rft.date=1997-05-01&rft.issn=0167-6806&rft.volume=44&rft.issue=1&rft.spage=65&rft_id=info:doi/10.1023%2FA%3A1005717924761&rft_id=info%3Apmid%2F9164679&rft.externalDocID=9164679 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0167-6806&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0167-6806&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0167-6806&client=summon |