Genetic linkage studies of thyroid peroxidase (TPO) gene in families with TPO deficiency

We have conducted biochemical and genetic studies in five unrelated families (denoted A, C, R, P, and G), which included nine goitrous subjects (five borderline euthyroid and four hypothyroid) with complete (n = 6) or partial (n = 3) thyroid peroxidase (TPO) deficiency. Thyroid tissue was obtained f...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism Jg. 72; H. 2; S. 471
Hauptverfasser:	Mangklabruks, A, Billerbeck, A E, Wajchenberg, B, Knobel, M, Cox, N J, DeGroot, L J, Medeiros-Neto, G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.1991
Schlagworte:	Bacterial Proteins Deoxyribonucleases, Type II Site-Specific DNA - genetics DNA Restriction Enzymes Female Genetic Linkage Humans Iodide Peroxidase - deficiency Iodide Peroxidase - genetics Iodides - metabolism Lod Score Male Pedigree Polymorphism, Restriction Fragment Length Thyroid Gland - enzymology Thyroid Gland - physiopathology Thyrotropin - blood Thyrotropin-Releasing Hormone Thyroxine - blood Triiodothyronine - blood
ISSN:	0021-972X
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