Phenolic compounds as antidiabetic, anti‐inflammatory, and anticancer agents and improvement of their bioavailability by liposomes

Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro‐oxidative properties. Naturally, phenolics structurally range from a very simple phenolic molecule moiety to an intricate polymer. For decades, phenolic compounds have gained pronounc...

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Vydáno v:	Cell biochemistry and function Ročník 39; číslo 8; s. 926 - 944
Hlavní autoři:	Tatipamula, Vinay Bharadwaj, Kukavica, Biljana
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Wiley Subscription Services, Inc 01.12.2021
Témata:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants Antitumor agents Bioavailability Biological activity Cancer Chemical properties Diabetes mellitus Flavonoids Formulations Functional foods & nutraceuticals Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Inflammation Liposomes Liposomes - chemistry Molecular Structure Oxidation Phenolic acids Phenols Phenols - chemistry Phenols - pharmacology Polymers pro‐oxidative properties pro-oxidative properties flavonoids antioxidants liposomes phenolic acids
ISSN:	0263-6484, 1099-0844, 1099-0844
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Abstract	Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro‐oxidative properties. Naturally, phenolics structurally range from a very simple phenolic molecule moiety to an intricate polymer. For decades, phenolic compounds have gained pronounced attention because of their protective effects against degenerative disorders such as inflammation, diabetes and cancer. Physico‐chemical properties (eg, solubility) restricted their bioactivity and also limited their usage as nutraceutical ingredients. However, encapsulation technology like liposomal formulations has been developed for the delivery of phenolic compounds without affecting their original aesthetic and organoleptic property. Hence, this review outlines the antioxidant and pro‐oxidative properties of phenolic compounds and focuses on biological activity reports of flavonoids and phenolic acids as antidiabetic, anti‐inflammatory and anticancer agents. Also, the delivery applications of phenolic compounds as liposomes are discussed with few examples.
AbstractList	Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro‐oxidative properties. Naturally, phenolics structurally range from a very simple phenolic molecule moiety to an intricate polymer. For decades, phenolic compounds have gained pronounced attention because of their protective effects against degenerative disorders such as inflammation, diabetes and cancer. Physico‐chemical properties (eg, solubility) restricted their bioactivity and also limited their usage as nutraceutical ingredients. However, encapsulation technology like liposomal formulations has been developed for the delivery of phenolic compounds without affecting their original aesthetic and organoleptic property. Hence, this review outlines the antioxidant and pro‐oxidative properties of phenolic compounds and focuses on biological activity reports of flavonoids and phenolic acids as antidiabetic, anti‐inflammatory and anticancer agents. Also, the delivery applications of phenolic compounds as liposomes are discussed with few examples. Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro-oxidative properties. Naturally, phenolics structurally range from a very simple phenolic molecule moiety to an intricate polymer. For decades, phenolic compounds have gained pronounced attention because of their protective effects against degenerative disorders such as inflammation, diabetes and cancer. Physico-chemical properties (eg, solubility) restricted their bioactivity and also limited their usage as nutraceutical ingredients. However, encapsulation technology like liposomal formulations has been developed for the delivery of phenolic compounds without affecting their original aesthetic and organoleptic property. Hence, this review outlines the antioxidant and pro-oxidative properties of phenolic compounds and focuses on biological activity reports of flavonoids and phenolic acids as antidiabetic, anti-inflammatory and anticancer agents. Also, the delivery applications of phenolic compounds as liposomes are discussed with few examples.Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro-oxidative properties. Naturally, phenolics structurally range from a very simple phenolic molecule moiety to an intricate polymer. For decades, phenolic compounds have gained pronounced attention because of their protective effects against degenerative disorders such as inflammation, diabetes and cancer. Physico-chemical properties (eg, solubility) restricted their bioactivity and also limited their usage as nutraceutical ingredients. However, encapsulation technology like liposomal formulations has been developed for the delivery of phenolic compounds without affecting their original aesthetic and organoleptic property. Hence, this review outlines the antioxidant and pro-oxidative properties of phenolic compounds and focuses on biological activity reports of flavonoids and phenolic acids as antidiabetic, anti-inflammatory and anticancer agents. Also, the delivery applications of phenolic compounds as liposomes are discussed with few examples.
Author	Kukavica, Biljana Tatipamula, Vinay Bharadwaj
Author_xml	– sequence: 1 givenname: Vinay Bharadwaj orcidid: 0000-0002-9376-1911 surname: Tatipamula fullname: Tatipamula, Vinay Bharadwaj organization: Duy Tan University – sequence: 2 givenname: Biljana orcidid: 0000-0003-1530-0391 surname: Kukavica fullname: Kukavica, Biljana email: biljana.kukavica@pmf.unibl.org organization: University of Banja Luka
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Snippet	Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro‐oxidative properties. Naturally, phenolics... Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro-oxidative properties. Naturally, phenolics...
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SubjectTerms	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants Antitumor agents Bioavailability Biological activity Cancer Chemical properties Diabetes mellitus Flavonoids Formulations Functional foods & nutraceuticals Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Inflammation Liposomes Liposomes - chemistry Molecular Structure Oxidation Phenolic acids Phenols Phenols - chemistry Phenols - pharmacology Polymers pro‐oxidative properties
Title	Phenolic compounds as antidiabetic, anti‐inflammatory, and anticancer agents and improvement of their bioavailability by liposomes
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